Publications

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2013
Isothermal DNA amplification coupled to Au-nanoprobes for detection of mutations associated to Rifampicin resistance in Mycobacterium tuberculosis, Veigas, Bruno, Pedrosa Pedro, Couto Isabel, Viveiros Miguel, and Baptista Pedro V. , Journal of Nanobiotechnology, (2013)
Nanomaterials for reversion of multidrug resistance in cancer: a new hope for an old idea?, Conde, João, de la Fuente Jesus M., and Baptista Pedro V. , Front. Pharmacol., (2013)
Nanotechnology for Cancer Diagnostics and Therapy – An Update on Novel Molecular Players, Fernandes, Alexandra R., and Baptista Pedro Viana , Current Cancer Therapy Reviews, Volume 9, Issue 3, p.164-172, (2013) AbstractWebsite

Nanotechnology has emerged as a "disruptive technology" that may provide researchers with new and innovative ways to diagnose, treat and monitor cancer. In fact, nanomedicine approaches have delivered several strategies, such as new imaging agents, real-time assessments of therapeutic and surgical efficacy, multifunctional, targeted devices capable of bypassing biological barriers to target and silence specific pathways in tumours. Of particular interest, has been the increased capability to deliver multiple therapeutic agents directly to bulk cancer cells and cancer stem cells that play a critical role in cancer growth and metastasis. These multifunctional targeted nanoconjugates are also capable of avoiding cancer resistance and monitor predictive molecular changes that open the path for preventive action against pre-cancerous cells, minimizing costs and incidence of relapses. A myriad of nanoconjugates with effective silencing and site-targeting moieties can be developed by incorporating a diverse selection of targeting, diagnostic, and therapeutic components. A discussion of the integrative effort of nanotechnology systems with recent developments of biomolecular interactions in cancer progression is clearly required. Here, we will update the state of the art related to the development and applications of nanoscale platforms and novel biomolecular players in cancer diagnosis, imaging and treatment.

Plastic Compatible Sputtered Ta2O5 Sensitive Layer for Oxide Semiconductor TFT Sensors, Branquinho, R., Pinto J. V., Busani T., Barquinha P., Pereira L., Baptista P. V., Martins R., and Fortunato E. , J. Display Technol, Volume 9, p.723-728, (2013)
Association of FTO and PPARG polymorphisms with obesity in Portuguese women, Carlos, F. F., Silva-Nunes J., Flores O., Brito M., Doria G., Veiga L., and Baptista P. V. , Diabetes Metab Syndr Obes, Volume 6, p.241-5, (2013) AbstractWebsite

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Association of FTO and PPARG polymorphisms with obesity in Portuguese women., Carlos, Fabio Ferreira, Silva-Nunes Jose, Flores Orfeu, Brito Miguel, Doria Goncalo, Veiga Luisa, and Baptista Pedro Viana , Diabetes, metabolic syndrome and obesity : targets and therapy, Volume 6, p.241-5, (2013) Abstract

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Designing gold nanoparticles for in vivo gene silencing as a new therapeutic tool, Conde, J., Ambrosone A., Hernandez Y., Marchesano V., Tian F., Ricardo Ibarra M., Baptista P. V., Tortiglione C., and de la Fuente J. M. , Human Gene Therapy, Volume 24, Number 12, p.A24, (2013) Abstract

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In vivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models, Conde, Joao, Tian Furong, Hernandez Yulan, Bao Chenchen, Cui Daxiang, Janssen Klaus-Peter, Ricardo Ibarra M., Baptista Pedro V., Stoeger Tobias, and de la Fuente Jesus M. , Biomaterials, Volume 34, Number 31, p.7744-7753, (2013) Abstract

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Isothermal DNA amplification coupled to Au-nanoprobes for detection of mutations associated to Rifampicin resistance in Mycobacterium tuberculosis, Veigas, B., Pedrosa P., Couto I., Viveiros M., and Baptista P. V. , J Nanobiotechnology, Volume 11, p.38, (2013) AbstractWebsite

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Isothermal DNA amplification coupled to Aunanoprobes for detection of mutations associated to Rifampicin resistance in Mycobacterium tuberculosis, Veigas, Bruno, Pedrosa Pedro, Couto Isabel, Viveiros Miguel, and Baptista Pedro V. , Journal of Nanobiotechnology, Volume 11, (2013) Abstract

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Nanomaterials for reversion of multidrug resistance in cancer: a new hope for an old idea?, Conde, J., de la Fuente J. M., and Baptista P. V. , Front Pharmacol, Volume 4, p.134, (2013) AbstractWebsite

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Nanomaterials for reversion of multidrug resistance in cancer: a new hope for an old idea?, Conde, Joao, de la Fuente Jesus M., and V. Baptista Pedro , Frontiers in Pharmacology, Volume 4, (2013) Abstract

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2012
Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis, Machado, Diana, Couto Isabel, Perdigão João, Rodrigues Liliana, Portugal Isabel, Baptista Pedro, Veigas Bruno, Amaral Leonard, and Viveiros Miguel , PLoS ONE, Volume 7, Issue 4, p.e34538, (2012)
Effect of PEG biofunctional spacers and TAT peptide on dsRNA loading on gold nanoparticles, Sanz, Vanesa, Conde João, Hernández Yulán, Baptista Pedro V., Ibarra M. R., and de la Fuente Jesús M. , J. Nanoparticles Res., Volume 14, p.917, (2012)
Enhancement of antibiotic effect via gold:silver alloy nanoparticles, dos Santos, Margarida Moreira, Queiroz Margarida João, and Baptista Pedro V. , J. Nanopar. Res., Volume 14, p.859, (2012)
Gold and silver nanoparticles for clinical diagnostics - from genomics to proteomics, Larguinho, Miguel, and Baptista Pedro V. , J. Proteomics, Volume 75, p.2811-2823, (2012)
Modification of plasmid DNA topology by ‘histone-mimetic’ gold nanoparticles, Conde, João, Baptista Pedro V., Hernández Yulan, Sanz Vanesa, and de la Fuente Jesus M. , Nanomedicine, (2012)
Nanoparticles in molecular diagnostics. Nanoparticles in Translational Science and Medicine, Baptista, Pedro V., Doria Gonçalo, Quaresma Pedro, Cavadas Miguel, Neves Cristina S., Gomes Inês, Eaton Peter, Pereira Eulália, and Franco Ricardo , Progress in Molecular Biology and Translational Science, (2012)
Nanophotonics for Molecular Diagnostics and Therapy Applications, Conde, João, Rosa João, Lima João C., and Baptista Pedro V. , Int. J. Photoenergy, Volume 619530, (2012)
RNA quantification with gold nanoprobes for cancer diagnostics, Baptista, Pedro V. , Clinics in Laboratory Medicine, Volume 32, p.1-13, (2012)
Could gold nanoprobes be an important tool in cancer diagnostics?, Baptista, Pedro Viana , Expert Review of Molecular Diagnostics, Volume 12, Number 6, p.541-543, (2012) Abstract

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Design of Multifunctional Gold Nanoparticles for In Vitro and In Vivo Gene Silencing, Conde, Joao, Ambrosone Alfredo, Sanz Vanesa, Hernandez Yulan, Marchesano Valentina, Tian Furong, Child Hannah, Berry Catherine C., Ibarra Ricardo M., Baptista Pedro V., Tortiglione Claudia, and de la Fuente Jesus M. , Acs Nano, Volume 6, Number 9, p.8316-8324, (2012) Abstract

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Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection, Guirgis, Bassem S. S., Sa e Cunha Claudia, Gomes Ines, Cavadas Miguel, Silva Isabel, Doria Goncalo, Blatch Gregory L., Baptista Pedro V., Pereira Eulalia, Azzazy Hassan M. E., Mota Maria M., Prudencio Miguel, and Franco Ricardo , Analytical and Bioanalytical Chemistry, Volume 402, Number 3, p.1019-1027, (2012) Abstract

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Gold on paper-paper platform for Au-nanoprobe TB detection, Veigas, Bruno, Jacob Jorge M., Costa Mafalda N., Santos David S., Viveiros Miguel, Inacio Joao, Martins Rodrigo, Barquinha Pedro, Fortunato Elvira, and Baptista Pedro Viana , Lab on a Chip, Volume 12, Number 22, p.4802-4808, (2012) Abstract

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