Gold nanoparticle-based theranostics: disease diagnostics and treatment using a single nanomaterial
- Citation:
- Vinhas, Raquel, Milton Cordeiro, Fábio Carlos, Soraia Mendo, Alexandra Fernandes, Sara Figueiredo, and Pedro Baptista. "Gold nanoparticle-based theranostics: disease diagnostics and treatment using a single nanomaterial." Journal of Nanobiosensors in Disease Diagnosis (2015): 11-23.
Abstract:
Nanotheranostics takes advantage of nanotechnology-based systems in order to diagnose and treat a specific disease. This approach is particularly relevant for personalized medicine, allowing the detection of a disease at an early stage, to direct a suitable therapy toward the target tissue based on the molecular profile of the altered phenotype, subsequently facilitating disease monitoring and following treatment. A tailored strategy also enables to reduce the off-target effects associated with universal treatments and improve the safety profile of a given treatment. The unique optical properties of gold nanoparticles, their ease of surface modification, and high surface-to-volume ratio have made them central players in this area. By combining imaging, targeting, and therapeutic agents in a single vehicle, these nanoconjugates are (ought to be) an important tool in the clinics. In this review, the multifunctionality of gold nanoparticles as theranostics agents will be highlighted, as well as the requirements before the translation of these nanoplatforms into routine clinical practice.
