Mass Photometry
Mass Photometry is a bioanalytical technology that measures the mass of individual biomolecules or particles in solution, in their native state and without the need for labels, by quantifying light scattering.
Biophysical applications:
- Detect low-abundance species and verify sample purity
- Characterize sample heterogeneity
- Determine oligomeric states and characterize complexes
- Monitor complex, multistep processes and quantify biomolecule interactions
The TwoMP from Refeyn™ available at the BioLab has a wide mass range, allowing the study of different biomolecules, including proteins, DNA, RNA, large macromolecular complexes, nanostructures and even small viruses such as AAVs.
System characteristics:
|
Mass range |
30 kDa – 5 MDa |
|
Resolution (FWHM) |
25 kDa @ 66 kDa/ 60 kDa @ 660 kDa |
|
Mass precision |
± 2% |
|
Mass error |
± 5% (single measurement) |
|
Concentration range |
100 pM – 100 nM |
|
Sensitivity |
<< 1 ng of protein |
|
Wavelength |
488 nm |
Mass Photometry
Mass Photometry is a bioanalytical technology that measures the mass of individual biomolecules or particles in solution, in their native state and without the need for labels, by quantifying light scattering.
Biophysical applications:
- Detect low-abundance species and verify sample purity
- Characterize sample heterogeneity
- Determine oligomeric states and characterize complexes
- Monitor complex, multistep processes and quantify biomolecule interactions
The TwoMP from Refeyn™ available at the BioLab has a wide mass range, allowing the study of different biomolecules, including proteins, DNA, RNA, large macromolecular complexes, nanostructures and even small viruses such as AAVs.
System characteristics:
|
Mass range |
30 kDa – 5 MDa |
|
Resolution (FWHM) |
25 kDa @ 66 kDa/ 60 kDa @ 660 kDa |
|
Mass precision |
± 2% |
|
Mass error |
± 5% (single measurement) |
|
Concentration range |
100 pM – 100 nM |
|
Sensitivity |
<< 1 ng of protein |
|
Wavelength |
488 nm |
