The W/SeCys-FdhAB formate dehydrogenase from Desulfovibrio vulgaris Hildenborough
- Citation:
- Oliveira, AR, Mota C, Romão MJ, Pereira IAC. 2022. The W/SeCys-FdhAB formate dehydrogenase from Desulfovibrio vulgaris Hildenborough, 2022/06/10. Encyclopedia of Inorganic and Bioinorganic Chemistry. :1-12.
Abstract:
Abstract The W/SeCys-FdhAB formate dehydrogenase from Desulfovibrio vulgaris Hildenborough is a dimeric periplasmic enzyme that catalyzes the reversible oxidation of formate and reduction of CO2. It belongs to the group of metal-dependent FDHs, with a tungsten at the active site coordinated by two pyranopterin guanine dinucleotides, a selenocysteine, and one labile sulfur atom. FdhAB has a remarkably high activity and unusual tolerance to oxygen, making it an ideal model system to study biological CO2 reduction.
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