National Projects (on-going):

2022.06104.PTDC 

GlycOSELECT: Targeting a ‘toolbox’ of human microbiome O-Glycan-Selective proteins towards new approaches in cancer research

PI: Angelina Palma; Co-PI: Ana Luísa Carvalho

EXPL/BIA-BQM/1300/2021

Structural and biochemical characterization of PHA synthases towards novel Polyhydroxyalkanoates

PI: Cristiano Mota, Co-PI: Marcia Correia

EXPL/BIA-BQM/0011/2021

NETexplore: Understanding ligand interaction and allosteric modulation of the norepinephrine transporter (NET) 

PI: Aldino Viegas, Co-PI: Benedita Pinheiro

PTDC/BII-BBF/2050/2020

Understanding enzymatic CO2 reduction for enhanced hybrid catalysts

PI: Inês Cardoso Pereira, Co-PI: Maria João Romão

European Projects (on-going):

Horizon Europe ERA Chairs Actions

101087571

CryoEM@NOVA: a cryo electron microscopy hub enabling drug discovery

Co-Coordination: Hartmut Luecke & Maria João Romão

GlycoMed: A new generation of enzymes for biofilm dispersion and immunomodulation in cancer

PI: Pedro Bule (CIISA-FMV-UL)

National Projects (finished):

Detoxification of Hydrogen Peroxide by Pathogenic Bacteria - E.coli Tri-haem peroxidase as a model 

PI: Sofia Pauleta

PTDC/BIA-MIC/30696/2017

Bacterial ABC-type Multitask Energizers: one ATPase fits all? 

PI: Isabel Sá Nogueira

PTDC/BIA-MIC/31645/2017

Fighting Staphylococcus aureus - Peptidoglycan amidation as a new target

PI: Rita Sobral

PTDC/BIA-MIB/31730/2017

Glycan-human microbiome interaction: glycan diversity and recognition in the human gut with impact on health and nutrition

PI: Angelina Palma

PTDC/BII-BIO/28878/2017

Bio-inspired materials for fish spoilage control

PI: Ana Cecília Roque

"Aldehyde Oxidases in Drug Metabolism and Biocatalysis: Searching for the Substrate Specificity and Catalytic Mechanism ",

PI:  Maria João Romão

"B.EST.CBM: An integrative structural biology approach to characterise the protein-carbohydrate microbial recognition",

PI:  Ana Luísa Carvalho

"Nanoagentes de monoxido de carbono COGSs para combater a Artrite Reumatoide",

PI:  Teresa Santos Silva

"CtIncipedia – A multidisciplinary Chlamydia trachomatis inclusion membrane (Inc) proteins",

PI:  Jaime Mota

"Reduction of CO2 for sustainable biofuel production",

PI:  Inês Cardoso Pereira

"Molecular determinants of bacterial cellulosome diversity in different ecological niches",

PI:  Carlos Fontes

"ACTONP53: Targeting p53 family proteins: on the route to new anticancer agents",

PI:  Lucília Saraiva

"Modern Structural Biology: Resources for the advancement of in-house X-ray crystallography",

PI:  Ana Luísa Carvalho

"ENZYMATIC CATALYSIS - seeking a global picture", (FCUP and FCT/UNL)

PI:  Maria João Ramos

"Ionic Liquid-based systems for protein crystallization", (ITQB and FCT/UNL)

PI:  Magdalena Kowacz

"Pylori GlycoArrays: Development of microarrays from Helicobacter pylori cell surface glycome toward immunological and serological studies",

PI:  Angelina de Sá Palma

"Development of cohesin-microarrays for determining cohesin-dockerin specificities of novel cellulolytic species"

PI:  Benedita Pinheiro

"Nitric Oxide Synthase and 99mTc/Re complexes bearing L-arginine derivatives: Structure-activity relationship", (ITN and FCT/UNL)

PI:  João Domingos Galamba Correia

“Protein interaction with CO Releasing Molecules (CORM)”,

PI: Teresa Santos-Silva

“Mammalian and Bacterial Aldehyde Oxidases: Structure, mechanism and insights into cofactor binding and protein maturation”,

PI: Teresa Santos-Silva

“A carbohydrate microarray platform for discovery of ligands in polysaccharides recognised by microbial carbohydrate-binding modules”,

PI: Maria Angelina Palma

“Structure and function of novel Glycoside Hydrolases and Carbohydrate-Binding Modules of Clostridium thermocellum cellulosome”,

PI: Shabir Najmudin

"The Cellulosome assembly: structure, function and specificity of new cellulases and supramolecular complexes",

PI: Ana Luisa Carvalho

“Production of a stable form of human phenylalanine hydroxylase: towards the 3D structure determination.” (FCT-UNL and FF-UL)

PI: Ana Paula Leandro

“Xanthine Oxidase-Related Enzymes: Structure, Function and Specificity” (FCT-UNL),

PI: Maria João Romão

“Structural and Functional Studies of the SOUL/HBP Family of Heme-binding Proteins” (UA and FCT-UNL),

PI: Brian James Goodfellow

“Structural characterization of mRNA localization mechanisms” (FCT-UNL and Univ. Leeds, UK).

PI: José Trincão

“Structural and Functional Characterization of Nitrate Reductases and Formate Dehydrogenases” (FCT-UNL),

PI: Maria João Romão.

“Molecular determinants of ligand specificity in carbohydrate-binding modules and cohesin-dockerin complexes” (FMV-UTL and FCT-UNL)

“Novo Tipo de Compostos Orientados para Receptores Biológicos com Potenciais Aplicações Farmacológicas” (IST and FCT-UNL)

“New molybdo and copper cofactors in proteins isolated from sulfate reducers” (FCT-UNL),

PI: Isabel Moura

“Bacterial Cytochrome c Peroxidases-Activation, Enzymatic Mechanism and Structure”

“A crystallographic contribution to the understanding of the structure and function of Mo-enzymes”,

PI: Maria João Romão.

“Molecular Biology and Structural Studies in Metalloproteins”

“Estrutura e função de novos módulos de ligação a carbohidratos e complexos coesina-doquerina do Clostridium thermocellum” (FMV-UTL and FCT-UNL),

PI: Carlos Fontes

“A combined approach of X-ray Crystallography, NMR and Computational Chemistry for the study of the molecular interactions that define the ligand specificity in cellulosomal Carbohydrate Binding Module” (FCT-UNL, FCUP and FMV-UTL),

PI: Ana Luísa Carvalho.

European Projects (finished):

European Research Network TMR: (HPRN-CT-1999-00084) “The Mechanism, Specificity and Inhibition of Enzymes belonging to the Xantine Oxidase family: Medical and Industrial Applications.”, joint collaboration of eight European research groups.

European Research Network TMR(FMRX-CT98-0204): “Structures and Reaction Mechanisms of Pteridine Related Enzymes”, collaboration among seven European research groups, including Industry (Zeneca Agrochemicals).

1996/1999:

BIOTECH”, (BIO4-CT96-0413) “Construction of Novel Redox Proteins from modular building blocks”. (six European laboratories).

”HUMAN CAPITAL AND MOBILITY NETWORK”, (ERBCHXCT 930243) “Pteridines: Regulation, Biosynthesis and Pharmacology”. (eight European research groups).