Publications

Export 95 results:

]

2014

Santos, MFA, Correia I, Oliveira AR, Garribba E, Pessoa JC, Santos-Silva T. 2014. Vanadium Complexes as Prospective Therapeutics: Structural Characterization of a VIV Lysozyme Adduct. European Journal of Inorganic Chemistry. :n/a–n/a.: WILEY-VCH Verlag AbstractWebsite

The biological activity of vanadium complexes, namely, as insulin enhancers, is well known. We report a combined X-ray crystallography, electron paramagnetic resonance, and density functional theory study of the interaction of vanadium picolinate complexes with hen egg white lysozyme (HEWL). We show that the VIVO(pic)2 complex covalently binds to the COO– group of the side chain of Asp52 of HEWL. The long VIV=O bond obtained in the X-ray study is explained to be due to reduction of VIV to VIII during exposure of the crystals to the intense X-ray beam.

2013

Seixas, JD, Mukhopadhyay A, Santos-Silva T, Otterbein LE, Gallo DJ, Rodrigues SS, Guerreiro BH, Goncalves AML, Penacho N, Marques AR, Coelho AC, Reis PM, Romao MJ, Romao CC. 2013. Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics. Dalton Transactions. 42:5985-5998., Number 17 AbstractWebsite

n/a

Mehtab, S, Goncalves G, Roy S, Tomaz AI, Santos-Silva T, Santos MFA, Romao MJ, Jakusch T, Kiss T, Pessoa JC. 2013. Interaction of vanadium(IV) with human serum apo-transferrin. Journal of Inorganic Biochemistry. 121:187-195. AbstractWebsite

n/a

Marangon, J, Correia HD, Brondino CD, Moura JJG, Romao MJ, Gonzalez PJ, Santos-Silva T. 2013. Kinetic and Structural Studies of Aldehyde Oxidoreductase from Desulfovibrio gigas Reveal a Dithiolene-Based Chemistry for Enzyme Activation and Inhibition by H2O2. Plos One. 8, Number 12 AbstractWebsite

n/a

Verma, AK, Goyal A, Freire F, Bule P, Venditto I, Bras JLA, Santos H, Cardoso V, Bonifacio C, Thompson A, Romao MJ, Prates JAM, Ferreira LMA, Fontes CMGA, Najmudin S. 2013. Overexpression, crystallization and preliminary X-ray crystallographic analysis of glucuronoxylan xylanohydrolase (Xyn30A) from Clostridium thermocellum. Acta Crystallographica Section F-Structural Biology and Crystallization Communications. 69:1440-1442. AbstractWebsite

n/a

Viegas, A, Sardinha J, Freire F, Duarte DF, Carvalho AL, Fontes CMGA, Romao MJ, Macedo AL, Cabrita EJ. 2013. Solution structure, dynamics and binding studies of a family 11 carbohydrate-binding module from Clostridium thermocellum (CtCBM11). Biochemical Journal. 451:289-300. AbstractWebsite

n/a

Santos, MFA, Oliveira AR, Somnath R, Romao MJ, Pessoa JC, Santos-Silva T. 2013. Vanadium compounds as prospective therapeutics: X-ray structure of protein adducts. European Biophysics Journal with Biophysics Letters. 42:S181-S181. AbstractWebsite

n/a

2012

Santos, MFA, Seixas JD, Coelho AC, Mukhopadhyay A, Reis PM, Romao MJ, Romao CC, Santos-Silva T. 2012. New insights into the chemistry of fac- Ru(CO)(3) (2+) fragments in biologically relevant conditions: The CO releasing activity of Ru(CO)(3)Cl-2(1,3-thiazole) , and the X-ray crystal structure of its adduct with lysozyme. Journal of Inorganic Biochemistry. 117:285-291. AbstractWebsite

n/a

2011

Mahro, M, Coelho C, Trincao J, Rodrigues D, Terao M, Garattini E, Saggu M, Lendzian F, Hildebrandt P, Romao MJ, Leimkuehler S. 2011. Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression. Drug Metabolism and Disposition. 39:1939-1945., Number 10 AbstractWebsite

n/a

Santos-Silva, T, Mukhopadhyay A, Seixas JD, Bernardes GJL, Romao CC, Romao MJ. 2011. CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II) Dicarbonyl-Lysozyme Complex. Journal of the American Chemical Society. 133:1192-1195., Number 5 AbstractWebsite

n/a

Mukhopadhyay, A, Kladova AV, Bursakov SA, Gavel YO, Calvete JJ, Shnyrov VL, Moura I, Moura JJG, Romao MJ, Trincao J. 2011. Crystal structure of the zinc-, cobalt-, and iron-containing adenylate kinase from Desulfovibrio gigas: a novel metal-containing adenylate kinase from Gram-negative bacteria. Journal of Biological Inorganic Chemistry. 16:51-61., Number 1 AbstractWebsite

n/a

Garcia-Alvarez, B, Melero R, Dias FMV, Prates JAM, Fontes CMGA, Smith SP, Romao MJ, Carvalho AL, Llorca O. 2011. Molecular Architecture and Structural Transitions of a Clostridium thermocellum Mini-Cellulosome. Journal of Molecular Biology. 407:571-580., Number 4 AbstractWebsite

n/a

Santos-Silva, T, Mukhopadhyay A, Seixas JD, Bernardes GJL, Romao CC, Romao MJ. 2011. Towards Improved Therapeutic CORMs: Understanding the Reactivity of CORM-3 with Proteins. Current Medicinal Chemistry. 18:3361-3366., Number 22 AbstractWebsite

n/a

2010

Ribeiro, T, Santos-Silva T, Alves VD, Dias FMV, Luis AS, Prates JAM, Ferreira LMA, Romao MJ, Fontes CMGA. 2010. Family 42 carbohydrate-binding modules display multiple arabinoxylan-binding interfaces presenting different ligand affinities. Biochimica Et Biophysica Acta-Proteins and Proteomics. 1804:2054-2062., Number 10 AbstractWebsite

n/a

2009

Kladova, AV, Gavel YO, Mukhopaadhyay A, Boer DR, Teixeira S, Shnyrov VL, Moura I, Moura JJG, Romao MJ, Trincao J, Bursakov SA. 2009. Cobalt-, zinc- and iron-bound forms of adenylate kinase (AK) from the sulfate-reducing bacterium Desulfovibrio gigas: purification, crystallization and preliminary X-ray diffraction analysis. Acta Crystallographica Section F-Structural Biology and Crystallization Communications. 65:926-929. AbstractWebsite

n/a

Santos-Silva, T, Ferroni F, Thapper A, Marangon J, Gonzalez PJ, Rizzi AC, Moura I, Moura JJG, Romao MJ, Brondino CD. 2009. Kinetic, Structural, and EPR Studies Reveal That Aldehyde Oxidoreductase from Desulfovibrio gigas Does Not Need a Sulfido Ligand for Catalysis and Give Evidence for a Direct Mo-C Interaction in a Biological System. Journal of the American Chemical Society. 131:7990-7998., Number 23 AbstractWebsite

n/a

Viciosa, MT, Correia NT, Salmeron Sanchez M, Carvalho AL, Romao MJ, Gomez Ribelles JL, Dionisio M. 2009. Real-Time Monitoring of Molecular Dynamics of Ethylene Glycol Dimethacrylate Glass Former. Journal of Physical Chemistry B. 113:14209-14217., Number 43 AbstractWebsite

n/a

Honzicek, J, Mukhopadhyay A, Santos-Silva T, Romao MJ, Romao CC. 2009. Ring-Functionalized Molybdenocene Complexes. Organometallics. 28:2871-2879., Number 9 AbstractWebsite

n/a

2008

Chaves, S, Gil M, Canario S, Jelic R, Romao MJ, Trincao J, Herdtweck E, Sousa J, Diniz C, Fresco P, Santos AM. 2008. Biologically relevant O,S-donor compounds. Synthesis, molybdenum complexation and xanthine oxidase inhibition. Dalton Transactions. :1773-1782., Number 13 AbstractWebsite

n/a

Vidinha, P, Lourenco NMT, Pinheiro C, Bras AR, Carvalho T, Santos-Silva T, Mukhopadhyay A, Romao MJ, Parola J, Dionisio M, Cabral JMS, Afonso CAM, Barreiros S. 2008. Ion jelly: a tailor-made conducting material for smart electrochemical devices. Chemical Communications. :5842-5844., Number 44 AbstractWebsite

n/a

Gavel, OY, Kladova AV, Bursakov SA, Dias JM, Texeira S, Shnyrov VL, Moura JJG, Moura I, Romao MJ, Trincao J. 2008. Purification, crystallization and preliminary X-ray diffraction analysis of adenosine triphosphate sulfurylase (ATPS) from the sulfate-reducing bacterium Desulfovibrio desulfuricans ATCC 27774. Acta Crystallographica Section F-Structural Biology and Crystallization Communications. 64:593-595. AbstractWebsite

n/a

2007

Santos-Silva, T, Dias JM, Dolla A, Durand M-C, Goncalves LL, Lampreia J, Moura I, Romao MJ. 2007. Crystal structure of the 16 heme cytochrome from Desulfovibrio gigas: A glycosylated protein in a sulphate-reducing bacterium. Journal of Molecular Biology. 370:659-673., Number 4 AbstractWebsite

n/a

Carvalho, AL, Dias FMV, Nagy T, Prates JAM, Proctor MR, Smith N, Bayer EA, Davies GJ, Ferreira LMA, Romao MJ, Fontes CMGA, Gilbert HJ. 2007. Evidence for a dual binding mode of dockerin modules to cohesins. Proceedings of the National Academy of Sciences of the United States of America. 104:3089-3094., Number 9 AbstractWebsite

n/a

Fv, V, Violante S, Gomes C, Carvalho AL, Romao MJ, Gaspar MM, Cruz MEM, Soveral G, Wanders RJ, Leandro P, de Almeida TV. 2007. The human carnitine acylcarnitine translocase (hCACT): Strategies for its heterologous expression, purification and crystallization. Journal of Inherited Metabolic Disease. 30:53-53. AbstractWebsite

n/a

2006

Santos-Silva, T, Trincao J, Carvalho AL, Bonifacio C, Auchere F, Raleiras P, Moura I, Moura JJG, Romao MJ. 2006. The first crystal structure of class III superoxide reductase from Treponema pallidum. Journal of Biological Inorganic Chemistry. 11:548-558., Number 5 AbstractWebsite

n/a