ALDEHYDE OXIDASES

ALDEHYDE OXIDASES AND THEIR ROLE IN DRUG METABOLISM 

  • Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms. Mota, C., Esmaeeli, M., Coelho, C., Santos-Silva, T., Wolff, M., Foti, A., Leimkühler, S. & Romão, M. J., 1 May 2019, In : FEBS Open Bio. 9, 5, p. 925-934 10 p.
  • New insights about the monomer and homodimer structures of the human AOX1. Ferreira, P., Cerqueira, N. M. F. S. A., Coelho, C., Fernandes, P. A., Romão, M. J. & Ramos, M. J., 1 Jan 2019, In : Physical Chemistry Chemical Physics. 21, 25, p. 13545-13554 10 p.
  • Systematic exploration of predicted destabilizing nonsynonymous single nucleotide polymorphisms (nsSNPs) of human aldehyde oxidase: A Bio-informatics study. Coelho, C., Muthukumaran, J., Santos-Silva, T. & João Romão, M., 1 Dec 2019, In : Pharmacology Research and Perspectives. 7, 6, e00538.
  • Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics. Mota, C., Coelho, C., Leimkühler, S., Garattini, E., Terao, M., Santos-Silva, T. & Romão, M. J., 1 Aug 2018, In : Coordination Chemistry Reviews. 368, p. 35-59 25 p.
  • Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics. Romão, M. J., Coelho, C., Santos-Silva, T., Foti, A., Terao, M., Garattini, E. & Leimkühler, S., 1 Apr 2017, In : Current Opinion in Chemical Biology. 37, p. 39-47 9 p.
  • Optimization of the expression of human aldehyde oxidase for investigations of single-nucleotide polymorphisms. Foti, A., Hartmann, T., Coelho, C. M. C., Santos-Silva, T., Romão, M. J. & Leimkühler, S., 1 Aug 2016, In : Drug Metabolism And Disposition. 44, 8, p. 1277-1285 9 p.
  • Structure and function of mammalian aldehyde oxidases. Terao, M., Romao, M. J., Leimkuehler, S., Bolis, M., Fratelli, M., Coelho, C. M. C., Santos-Silva, T. S. & Garattini, E., Apr 2016, In : Archives Of Toxicology. 90, 4, p. 753-780 28 p.
  • Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidase. Cerqueira, N. M. F. S. A., Coelho, C. M. C., Brás, N. F., Fernandes, P. A., Garattini, E., Terao, M., Romão, M. J. & Ramos, M. J., 2015, In : Journal Of Biological Inorganic Chemistry. 20, 2, p. 209-217 9 p.
  • Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase. Coelho, C. M. C., Foti, A., Hartmann, T., Santos-Silva, T. S., Leimkühler, S. & Romão, M. J., 2015, In : Nature Chemical Biology. 11, 10, p. 779-783 5 p.
  • The first mammalian aldehyde oxidase crystal structure: Insights into substrate specificity. Coelho, C., Mahro, M., Trincão, J., Carvalho, A. T. P., Ramos, M. J., Terao, M., Garattini, E., Leimkühler, S. & Romão, M. J., 23 Nov 2012, In : Journal of Biological Chemistry. 287, 48, p. 40690-40702 13 p.