Latest research from our team members (2018 - present)

CAMPOS, S., RODRIGO, A.P., MOUTINHO CABRAL, I. MENDES, V., MANADAS, B., D'AMBROSIO, M. & COSTA, P.M. (2023). An exploration of novel bioactives from the venomous marine annelid Glycera alba. Toxins, 15, 655 (doi: 10.3390/toxins15110655). 

GONÇALVES, C., ALVES DE MATOS, A.P. & COSTA, P.M. (2023). Comparative analysis of the jaw apparatus of three marine annelids using scanning electron microscopy: Microstructure and elemental composition. Journal of Anatomy 243, 789-795 (doi: 10.1111/joa.13910).

VITORINO, J.D. & COSTA, P.M. (2023). After a century of research into environmental mutagens and carcinogens, where do we stand? International Journal of Environmental Research and Public Health 20, 1040 (doi: 10.3390/ijerph20021040).

MOUTINHO CABRAL, I., MADEIRA C., GROSSO, A.R. & COSTA, P.M. (2022). A drug discovery approach based on comparative transcriptomics between two toxin-secreting marine annelids: Glycera alba and Hediste diversicolor. Molecular Omics 18, 731-744 (doi: 10.1039/D2MO00138A).

LOPES, A.F., MURDOCH, R., MARTINS-CARDOSO, S., MADEIRA, C., COSTA, P.M., FÉLIX, A.S., OLIVEIRA, R.F., BANDARRA, N.M., VINAGRE, C., LOPES, A.R., GONÇALVES, E.J. & FARIA, A.M. (2022). Differential effects of food restriction and warming in the two-spotted goby: Impaired reproductive performance and stressed offspring. Fishes 7, 194 (doi: 10.3390/fishes7040194).

RODRIGO, A.P., LOPES, A., PEREIRA, R., ANJO, S.I., MANADAS, B., GROSSO, A.R., BAPTISTA, P.V., FERNANDES, A.R. & COSTA, P.M. (2022). Endogenous fluorescent proteins in the mucus of an intertidal Polychaeta: Clues for biotechnology. Marine Drugs 20, 224 (doi: 10.3390/md20040224).

D’AMBROSIO, M., RAMOS, I. MARTINS, C. & COSTA, P.M. (2022). An investigation into the toxicity of tissue extracts from two distinct marine Polychaeta. Toxicon: X 14, 100116 (doi: 10.1016/j.toxcx.2022.100116).

SANTOS, M.L., D’AMBROSIO, M., RODRIGO, A.P., PAROLA, A.J. & COSTA, P.M. (2021). A transcriptomic approach to the metabolism of tetrapyrrolic photosensitizers in a marine annelid. Molecules 26, 3924. (doi: 10.3390/molecules26133924)

D’AMBROSIO, M., GONÇALVES, C., CALMÃO, M., RODRIGUES, M. & COSTA, P.M. (2021). Localization and bioreactivity of cysteine-rich secretions in the marine gastropod Nucella lapillus. Marine Drugs 19, 276. (doi: 10.3390/md19050276)

MADEIRA, C. & COSTA, P.M. (2021). Proteomics in systems toxicology. In Donev, R. (Ed.). Advances in Protein Chemistry and Structural Biology Volume 127, pp. 55-91. Academic Press, London, UK (doi: 10.1016/bs.apcsb.2021.03.001).

GOSENS, I., COSTA, P.M., OLSSON, M., STONE, V., COSTA, A.L., BRUNELLI, A., BADETTI, E., BONETTO, A., BOKKERS, B.G.H., DE JONG, W.H., WILLIAMS, A., HALAPPANAVAR, S., FADEEL, B. & CASSEE, F.R. (2021). Pulmonary toxicity and gene expression changes after short-term inhalation exposure to surface-modified copper oxide nanoparticles. NanoImpact 22, 100313. (doi: 10.1016/j.impact.2021.100313)

GONÇALVES, C. & COSTA, P.M. (2021). Cephalotoxins: A hotspot for marine bioprospecting? Frontiers in Marine Science 8, 647344. (doi: 10.3389/fmars.2021.647344)

RODRIGO, A.P., GROSSO, A.R., BAPTISTA, P.V., FERNANDES, A.R., & COSTA, P.M. (2021). A transcriptomic approach to the recruitment of venom proteins in a marine annelid. Toxins 13, 97. (doi: 10.3390/toxins13020097) 

RODRIGO, A.P., MENDES, V.M., MANADAS, B., GROSSO, A.R., ALVES DE MATOS, A.P., BAPTISTA, P.V., COSTA, P.M., FERNANDES, A.R. (2021). Specific antiproliferative properties of proteinaceous toxin secretions from the marine annelid Eulalia sp. onto ovarian cancer cells. Marine Drugs 19, 31. (doi: 10.3390/md19010031)

MILHINHOS, A. & COSTA, P.M. (2020). On the progression of COVID-19 in Portugal: A comparative analysis of active cases using non-linear regression. Frontiers in Public Health 8, 495. (doi: 10.3389/fpubh.2020.00495)

GONÇALVES, C. & COSTA, P.M. (2020). Histochemical detection of free thiols in glandular cells and tissues of different marine Polychaeta. Histochemistry and Cell Biology 154, 315–325. (doi: 10.1007/s00418-020-01889-3)

D'AMBROSIO, M., SANTOS, A.C., ALEJO-ARMIJO, A., PAROLA, J. & COSTA, P.M. (2020). Light-mediated toxicity of porphyrin-like pigments from a marine polychaeta. Marine Drugs 18, 302. (doi: 10.3390/md18060302)

BEJAOUI, S., MICHÁN, C., TELAHIGUEC, K., NECHIC, S., EL CAFSIQ, M., SOUDANIB, N., BLASCO, J., COSTA, P.M. & ALHAMA, J. (2020). Metal body burden and tissue oxidative status in the bivalve Venerupis decussata. Assessment of environmental quality in transitional waters. Marine Environmental Research 159, 105000. (doi: 10.1016/j.marenvres.2020.105000)

MARTINS, C. & COSTA, P.M. (2020). Technical updates to the Comet assay in vivo for assessing DNA damage in zebrafish embryos from fresh and frozen cell suspensions. Zebrafish 17, 220-228. (doi: 10.1089/zeb.2020.1857)

MARTINS, C. DREIJ, K. & COSTA, P.M. (2019). The state-of-the art of environmental toxicogenomics: Challenges and perspectives of “omics” approaches directed to toxicant mixtures. International Journal of Environmental and Human Health 16, 4718. (doi: 10.3390/ijerph16234718) 

PEDROSA, P., CORVO, M.L., FERREIRA-SILVA, M., MARTINS, P., COLA CARVALHEIRO, M.C., COSTA, P.M., MARTINS, C., MARTINS, L.M.D.R.S., BAPTISTA, P.V. & FERNANDES, A.R. (2019). Targeting cancer resistance via multifunctional gold-nanoparticles. International Journal of Molecular Sciences 20, 5510. (doi: 10.3390/ijms20215510)

MARTINS, C., RODRIGO, A.P., CABRITA, L., HENRIQUES, P., PAROLA, A.J. & COSTA, P.M. (2019). The complexity of porphyrin-like pigments in a marine annelid sheds new light on haem metabolism in aquatic invertebrates. Scientific Reports 9, 12930. (doi: 10.1038/s41598-019-49433-1)

CUNHA, M.L., MARTINS, C., GROSSO, A.R. & COSTA, P.M. (2019). Mytilus galloprovincialis CYP1A-like mRNAs reveal closer proximity of mytilid CYP1A to the eumetazoan CYP2 Family. Aquatic Toxicology 214, 105260. (doi: 10.1016/j.aquatox.2019.105260)

RODRIGO, A.P., & COSTA, P.M. (2019). The hidden biotechnological potential of marine invertebrates: The Polychaeta case study. Environmental Research 173, 270-280. (doi: 10.1016/j.envres.2019.03.048)

ALVES-BARROCO, C., ROMA-RODRIGUES, C., RAPOSO, L.R., BRÁS, C., DINIZ, M.,  CAÇO; J., COSTA, P.M., SANTOS-SANCHES, I., & FERNANDES, A.R. (2019). Streptococcus dysgalactiae subsp. dysgalactiae isolated from milk of the bovine udder as emerging pathogens: In vitro and in vivo infection of human cells and zebrafish (Danio rerio) as biological models. MicrobiologyOpen  8,(1), e00623 (doi: 10.1002/mbo3.623) 

GONÇALVES, C., MARTINS, M., SOBRAL, P., COSTA, P.M., COSTA, M.H. (2019). An assessment of the ability to ingest and excrete microplastics by filter-feeders: A  case study with the Mediterranean mussel. Environmental Pollution 245, 600-606. (doi: 10.1016/j.envpol.2018.11.038)

RODRIGO, A.P.C., MARTINS, C., ALVES DE MATOS, A.P., COSTA, M.H. & COSTA, P.M. (2018). A morphoanatomical approach to the adaptive features of the epidermis and proboscis of a marine Polychaeta: Eulalia viridis (Phyllodocida: Phyllodocidae). Journal of Anatomy  233, 567-579. (doi: 10.1111/JOA.12870).

CUEVAS, N., MARTINS, M., RODRIGO, A.P., MARTINS, C. & COSTA, P.M. (2018). Explorations on the ecological role of toxin secretion and delivery in jawless predatory Polychaeta. Scientific Reports 8, 7635 (doi: 10.1038/s41598-018-26031-1)

CUEVAS, N., MARTINS, M. & COSTA, P.M. (2018). Risk assessment of pesticides in estuaries: A review addressing the persistence of an old problem in complex environments. Ecotoxicology 27, 1008–1018. (doi: 10.1007/s10646-018-1910-z)

MARTINS, M., SILVA, A., COSTA, M.H., MIGUEL, C. & COSTA, P.M. (2018). Co-exposure to environmental carcinogens in vivo triggers neoplasia-related hallmarks in low-genotoxicity events, even after removal of insult. Scientific Reports 8, 3649. (doi: 10.1038/s41598-018-21975-w)

BHATTACHARYA, K., SACCHETTI, C., COSTA, P.M., SOMMERTUNE, J., BRANDNER, B.D., MAGRINI, A., ROSATO, N., BOTTINI, N., BOTTINI, M. & FADEEL, B. (2018). Nitric oxide-dependent degradation of polyethylene glycol-modified single-walled carbon nanotubes: Implications for intra-articular delivery. Advanced Healthcare Materials, 7, 1700916. (doi: 10.1002/adhm.201700916)

GONÇALVES, C., MARTINS, M., COSTA, M.H., COSTA, P.M. (2018). Development of a method for the detection of polystyrene microplastics in paraffin-embedded histological sections. Histochemistry and Cell Biology 149, 187–191. (doi: 10.1007/s00418-017-1613-1)

LÍBALOVÁ, H., COSTA, P.M., OLSSON, M., FARCAL, L., ORTELLI, S., BLOSI, M., TOPINKA, J., COSTA, A.L. & FADEEL, B. (2018). Toxicity of surface-modified copper oxide nanoparticles in a mouse macrophage cell line: Interplay of particles, surface coating and particle dissolution. Chemosphere 196, 482–493. (doi: 10.1016/j.chemosphere.2017.12.182)

COSTA, P.M., GOSENS, I., WILLIAMS, A., FARCAL, L., PANTANO, D., BROWN, D.M., STONE, V., CASSEE, F.R., HALAPPANAVAR, S. & FADEEL, B. (2018). Transcriptional profiling reveals gene expression changes associated with inflammation and cell proliferation following short-term inhalation exposure to copper oxide nanoparticles. Journal of Applied Toxicology  38, 385–397. (doi: 10.1002/jat.3548)