Citation:

Structural aspects of a trimetallic Cu II derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines, Das, Kuheli, Datta Amitabha, Massera Chiara, Roma-Rodrigues Catarina, Barroso Mariana, Baptista {Pedro V. }, and Fernandes {Alexandra R. } , Journal of Coordination Chemistry, apr, Volume 72, Number 5-7, p.920–940, (2019)

Abstract:

A trimetallic Cu II derivative, [Cu 3 (L) 2 (CF 3 COO) 2 ] (1) (where H 2 L = N,N′-bis(salicylidene)-1,3-propanediamine), was prepared and characterized. In 1, the two terminal Cu II ions are linked to the central Cu II by trifluoroacetato and doubly bridging phenoxido. Both the square-pyramidal and octahedral geometries are observed among two different Cu II centers in the linear arrangement of the trimetallic unit. Compound 1 is characterized by IR and UV-Vis spectra. Compound 1 has high cytotoxic activity in breast adenocarcinoma (MCF-7), colorectal carcinoma (HCT116) and particularly, in ovarian carcinoma (A2780) cell line compared to a lung adenocarcinoma cell line. The IC 50 in A2780 cells is 25 times lower than the respective value for normal human primary fibroblasts demonstrating 1 has higher cytotoxicity towards cancer cells. Additionally, combination of DOX with 1 induces a higher loss of HCT116 cell viability compared with each drug alone.

Notes:

info:eu-repo/grantAgreement/FCT/5876/147258/PT# co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728).