Citation:

A promising road with challenges: where are gold nanoparticles in translational research?, Bao, Chenchen, Conde João, Polo Ester, {del Pino} Pablo, Moros Maria, Baptista Pedro, Grazu Valeria, Cui Daxiang, and {de la Fuente} {Jesus M. } , Nanomedicine, Volume 9, Number 15, p.2353–2370, (2014)

Abstract:

Nanoenabled technology holds great potential for health issues and biological research. Among the numerous inorganic nanoparticles that are available today, gold nanoparticles are fully developed as therapeutic and diagnostic agents both in vitro and in vivo due to their physicochemical properties. Owing to this, substantial work has been conducted in terms of developing biosensors for noninvasive and targeted tumor diagnosis and treatment. Some studies have even expanded into clinical trials. This article focuses on the fundamentals and synthesis of gold nanoparticles, as well as the latest, most promising applications in cancer research, such as molecular diagnostics, immunosensors, surface-enhanced Raman spectroscopy and bioimaging. Challenges to their further translational development are also discussed.

Notes:

info:eu-repo/grantAgreement/EC/FP7/626386/EU# National Key Basic Research Program (973 Project; no. 2010CB933901) National Natural Scientific Fund (no. 81225010) 863 project of China (2012AA022703 and 2014AA020700) Shanghai Science and Technology Fund (no. 13NM1401500 and 11nm0504200) Shanghai 1000 People Plan, MAT2011-26851-C02-01 Sem PDF conforme despacho.