Citation:

POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy, Restani, {Rita B. }, Pires {Rita F. }, Tolmatcheva Anna, Cabral Rita, Baptista {Pedro V. }, Fernandes {Alexandra R. }, Casimiro Teresa, Bonifácio {Vasco D. B. }, and Aguiar-Ricardo Ana , ChemistryOpen, oct, Volume 7, Number 10, p.772–779, (2018)

Abstract:

POxylated polyurea dendrimer (PUREG4OOx48)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.

Notes:

Sem PDF conforme despacho. info:eu-repo/grantAgreement/FCT/5876/147218/PT# info:eu-repo/grantAgreement/FCT/5876/147258/PT# info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F66858%2F2009/PT# This work was supported by the Associate Laboratory for Green Chemistry-LAQV, which is financed by national funds from FCT/MCTES (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER -007265), the Unidade de Cithornncias Biomoleculares Aplicadas UCIBIO-REQUIMTE, which is financed by national funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728). The authors acknowledge the Ph.D. grants SFRH/BD/66858/2009 (R.B.R.) and SFRH/BD/109006/2015 (R.F.P.). T.C. also acknowledges FCT-Lisbon for the IF/00915/2014 contract.