Citation:

Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules, Fernandes, {Alexandra R. }, c}a-Martins Inês Mendon{\c, Santos {Marino F. A. }, Raposo {Luís R. }, Mendes Rita, Marques Joana, Romão {Carlos C. }, Romão {Maria João}, Santos-Silva Teresa, and Baptista {Pedro V. } , ACS Biomaterials Science and Engineering, feb, Volume 6, Number 2, p.1090–1101, (2020)

Abstract:

CO-releasing molecules (CORMs) have been widely studied for their anti-inflammatory, antiapoptotic, and antiproliferative effects. CORM-3 is a water-soluble Ru-based metal carbonyl complex, which metallates serum proteins and readily releases CO in biological media. In this work, we evaluated the anti-inflammatory and wound-healing effects of gold nanoparticles-CORM-3 conjugates, AuNPs@PEG@BSA·Ru(CO)x, exploring its use as an efficient CO carrier. Our results suggest that the nanoformulation was capable of inducing a more pronounced cell effect, at the anti-inflammatory level and a faster tissue repair, probably derived from a rapid cell uptake of the nanoformulation that results in the increase of CO inside the cell.

Notes:

UID/Multi/04378/2019 FCT/MEC PTDC/QEQMED/1902/2014 Sem PDF conforme despacho.