Current trends in molecular diagnostics of chronic myeloid leukemia

Citation:
Current trends in molecular diagnostics of chronic myeloid leukemia, Vinhas, Raquel, Cordeiro Milton, Pedrosa Pedro, Fernandes Alexandra R., and Baptista Pedro V. , Leukemia & Lymphoma, p.1-14, (2016)

Abstract:

Nearly 1.5 million people worldwide suffer from chronic myeloid leukemia (CML), characterized by the genetic translocation t(9;22)(q34;q11.2), involving the fusion of the Abelson oncogene (ABL1) with the breakpoint cluster region (BCR) gene. Early onset diagnosis coupled to current therapeutics allow for a treatment success rate of 90, which has focused research on the development of novel diagnostics approaches. In this review, we present a critical perspective on current strategies for CML diagnostics, comparing to gold standard methodologies and with an eye on the future trends on nanotheranostics.

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