Citation:

Current trends in molecular diagnostics of chronic myeloid leukemia, Vinhas, Raquel, Cordeiro Milton, Pedrosa Pedro, Fernandes {Alexandra R. }, and Baptista {Pedro V. } , Leukemia & Lymphoma, aug, Volume 58, Number 8, p.1791–1804, (2017)

Abstract:

Nearly 1.5 million people worldwide suffer from chronic myeloid leukemia (CML), characterized by the genetic translocation t(9;22)(q34;q11.2), involving the fusion of the Abelson oncogene (ABL1) with the breakpoint cluster region (BCR) gene. Early onset diagnosis coupled to current therapeutics allow for a treatment success rate of 90, which has focused research on the development of novel diagnostics approaches. In this review, we present a critical perspective on current strategies for CML diagnostics, comparing to gold standard methodologies and with an eye on the future trends on nanotheranostics.

Notes:

sem pdf. Fundacao para a Ciencia e a Tecnologia (FCT/MEC - Project UCIBIO) - UID/Multi/04378/ 2013 ; ERDF - POCI-01-0145-FEDER-007728 ; FCT/MEC - (PD/BD/52211/2013; SFRH/BD/87836/2012; PD/BD/105734/2014)