Publications

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Journal Article
Larguinho, Miguel, Ana Cordeiro, Mario S. Diniz, Pedro M. Costa, and Pedro V. Baptista. "Metabolic and histopathological alterations in the marine bivalve Mytilus galloprovincialis induced by chronic exposure to acrylamide." Environmental Research 135 (2014): 55-62. Abstract

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Doria, Gonçalo, Ricardo Franco, and Pedro Baptista. "Nanodiagnostics: Fast Colorimetric Method for Single Nucleotide Polymorphism/Mutation Detection." IET Nanobiotechnol. 1 (2007): 53-57.
Doria, G., R. Franco, and P. Baptista. "Nanodiagnostics: fast colorimetric method for single nucleotide polymorphism/mutation detection." Iet Nanobiotechnology 1 (2007): 53-57. Abstract

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McCully, Mark, João Conde, Pedro V. Baptista, Margaret Mullin, Matthew J. Dalby, and Catherine C. Berry. "Nanoparticle-antagomiR based targeting of miR-31 to induce osterix and osteocalcin expression in mesenchymal stem cells." PLOS ONE 13 (2018): e0192562-. AbstractWebsite

Mesenchymal stem cells are multipotent adult stem cells capable of generating bone, cartilage and fat, and are thus currently being exploited for regenerative medicine. When considering osteogenesis, developments have been made with regards to chemical induction (e.g. differentiation media) and physical induction (e.g. material stiffness, nanotopography), targeting established early transcription factors or regulators such as runx2 or bone morphogenic proteins and promoting increased numbers of cells committing to osteo-specific differentiation. Recent research highlighted the involvement of microRNAs in lineage commitment and terminal differentiation. Herein, gold nanoparticles that confer stability to short single stranded RNAs were used to deliver MiR-31 antagomiRs to both pre-osteoblastic cells and primary human MSCs in vitro. Results showed that blocking miR-31 led to an increase in osterix protein in both cell types at day 7, with an increase in osteocalcin at day 21, suggesting MSC osteogenesis. In addition, it was noted that antagomiR sequence direction was important, with the 5 prime reading direction proving more effective than the 3 prime. This study highlights the potential that miRNA antagomiR-tagged nanoparticles offer as novel therapeutics in regenerative medicine.

McCully, Mark, Joao Conde, Pedro V. Baptista, Margaret Mullin, Matthew J. Dalby, and Catherine C. Berry. "Nanoparticle-antagomiR based targeting of miR-31 to induce osterix and osteocalcin expression in mesenchymal stem cells." Plos One 13 (2018). Abstract

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Baptista, P. V., G. Doria, P. Quaresma, M. Cavadas, C. S. Neves, I. Gomes, P. Eaton, E. Pereira, and R. Franco. "Nanoparticles in molecular diagnostics." Prog. Mol. Biol. Transl. Sci. 104 (2011): 427-488.
Baptista, P. V., G. Doria, P. Quaresma, M. Cavadas, C. S. Neves, I. Gomes, P. Eaton, E. Pereira, and R. Franco. "Nanoparticles in molecular diagnostics." Prog Mol Biol Transl Sci 104 (2011): 427-88. AbstractWebsite

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Baptista, Pedro V., Goncalo Doria, Pedro Quaresma, Miguel Cavadas, Cristina S. Neves, Ines Gomes, Peter Eaton, Eulalia Pereira, Ricardo Franco, and A. Villaverde. "Nanoparticles in Molecular Diagnostics." Nanoparticles in Translational Science and Medicine 104 (2011): 427-488. Abstract

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Conde, Joao, Goncalo Doria, and Pedro Baptista. "Noble metal nanoparticles applications in cancer." Journal of drug delivery 2012 (2012): 751075. Abstract

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Doria, G., J. Conde, B. Veigas, L. Giestas, C. Almeida, M. Assunção, J. Rosa, and P. V. Baptista. "Noble metal nanoparticles for biosensing applications." Sensors (Basel) 12 (2012): 1657-87. AbstractWebsite

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Silva, LB, P. Baptista, L. Raniero, G. Doria, R. Franco, R. Martins, E. Fortunato, and IEEE. "Novel optoelectronic platform using an amorphous/nanocrystalline silicon biosensor for the specific identification of unamplified nucleic acid sequences based on gold nanoparticle probes." Transducers '07 & Eurosensors Xxi, Digest of Technical Papers, Vols 1 and 2 (2007): U472-U473. Abstract

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Kourmentza, C., D. Araujo, C. Sevrin, C. Roma-Rodriques, J. Lia Ferreira, F. Freitas, M. Dionisio, P. V. Baptista, A. R. Fernandes, C. Grandfils, and M. A. M. Reis. "Occurrence of non-toxic bioemulsifiers during polyhydroxyalkanoate production by Pseudomonas strains valorizing crude glycerol by-product." Bioresour Technol 281 (2019): 31-40. AbstractWebsite

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Doria, Gonçalo, Bernhard G. Baumgartner, Ricardo Franco, and Pedro V. Baptista. "Optimizing Au-nanoprobes for specific sequence discrimination." Colloids Surf. B: Biointerfaces 77 (2010): 122-124.
Silva, LB, B. Veigas, G. Doria, P. Costa, J. Inácio, R. Martins, E. Fortunato, and P. V. Baptista. "Portable optoelectronic biosensing platform for identification of mycobacteria from the Mycobacterium tuberculosis complex." Biosens Bioelectron 26 (2011): 2012-7. AbstractWebsite

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Conde, Joao, Jorge T. Dias, Valeria Grazu, Maria Moros, Pedro V. Baptista, and Jesus M. de la Fuente. "Revisiting 30 years of biofunctionalization and surface chemistry of inorganic nanoparticles for nanomedicine." Frontiers in Chemistry 2 (2014). Abstract

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Conde, J., G. Doria, J. M. de la Fuente, and P. V. Baptista. "RNA quantification using noble metal nanoprobes: simultaneous identification of several different mRNA targets using color multiplexing and application to cancer diagnostics." Methods Mol Biol 906 (2012): 71-87. AbstractWebsite

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Quaresma, Pedro, Ines Osorio, Goncalo Doria, Patricia A. Carvalho, Andre Pereira, Judith Langer, Joao Pedro Araujo, Isabel Pastoriza-Santos, Luis M. Liz-Marzan, Ricardo Franco, Pedro V. Baptista, and Eulalia Pereira. "Star-shaped magnetite@gold nanoparticles for protein magnetic separation and SERS detection." Rsc Advances 4 (2014): 3659-3667. AbstractWebsite

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Das, Kuheli, Amitabha Datta, Chiara Massera, Catarina Roma-Rodrigues, Mariana Barroso, Pedro V. Baptista, and Alexandra R. Fernandes. "Structural aspects of a trimetallic CuII derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines." Journal of Coordination Chemistry 72 (2019): 920-940. AbstractWebsite

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Daniela, Peixoto, Figueiredo Margarida, Malta Gabriela, Roma‐Rodrigues Catarina, Baptista Pedro V., Fernandes Alexandra R., Barroso Sónia, Carvalho Ana Luísa, Afonso Carlos A. M., Ferreira Luisa M., and Branco Paula S. "Synthesis, Cytotoxicity Evaluation in Human Cell Lines and in Vitro DNA Interaction of a Hetero‐Arylidene‐9(10H)‐Anthrone." European Journal of Organic ChemistryEuropean Journal of Organic Chemistry 2018 (2018): 545-549. AbstractWebsite

A new and never before reported hetero?arylidene?9(10H)?anthrone structure (4) was unexpectedly isolated on reaction of 1,2?dimethyl?3?ethylimidazolium iodide (2) and 9?anthracenecarboxaldehyde (3) under basic conditions. Its structure was unequivocally confirmed by X?ray crystallography. No cytotoxicity in human healthy fibroblasts and in two different cancer cell lines was observed, indicating its applicability in biological systems. Compound 4 interacts with CT?DNA by intercalation between the adjacent base pairs of DNA with a high binding affinity [Kb = 2.0?(±0.20)???105 m?1], which is 10?? higher than that described for doxorubicin [Kb = 3.2?(±0.23)???104 m?1]. Furthermore, compound 4 quenches the fluorescence emission of a GelRed?CT?DNA system with a quenching constant (KSV) of 3.3?(±0.3)???103 m?1 calculated by the Stern?Volmer equation.