Publications

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2013
Bernacka-Wojcik, Iwona, Paulo Lopes, Ana Catarina Vaz, Bruno Veigas, Pawel Jerzy Wojcik, Pedro Simões, David Barata, Elvira Fortunato, Pedro V. Baptista, Hugo Águas, and Rodrigo Martins. "Bio-microfluidic platform for gold nanoprobe based DNA detection—application to Mycobacterium tuberculosis." Biosens Bioelectron 48 (2013): 87-93. AbstractWebsite

We have projected and fabricated a microfluidic platform for DNA sensing that makes use of an optical colorimetric detection method based on gold nanoparticles. The platform was fabricated using replica moulding technology in PDMS patterned by high-aspect-ratio SU-8 moulds. Biochips of various geometries were tested and evaluated in order to find out the most efficient architecture, and the rational for design, microfabrication and detection performance is presented. The best biochip configuration has been successfully applied to the DNA detection of Mycobacterium tuberculosis using only 3 µl on DNA solution (i.e. 90 ng of target DNA), therefore a 20-fold reduction of reagents volume is obtained when compared with the actual state of the art.

Conde, J., A. Ambrosone, Y. Hernandez, V. Marchesano, F. Tian, M. Ricardo Ibarra, P. V. Baptista, C. Tortiglione, and J. M. de la Fuente. "Designing gold nanoparticles for in vivo gene silencing as a new therapeutic tool." Human Gene Therapy 24 (2013): A24. Abstract

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2012
Machado, Diana, Isabel Couto, João Perdigão, Liliana Rodrigues, Isabel Portugal, Pedro Baptista, Bruno Veigas, Leonard Amaral, and Miguel Viveiros. "Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis." PLoS ONE 7 (2012): e34538.
Conde, Joao, Alfredo Ambrosone, Vanesa Sanz, Yulan Hernandez, Valentina Marchesano, Furong Tian, Hannah Child, Catherine C. Berry, Ricardo M. Ibarra, Pedro V. Baptista, Claudia Tortiglione, and Jesus M. de la Fuente. "Design of Multifunctional Gold Nanoparticles for In Vitro and In Vivo Gene Silencing." Acs Nano 6 (2012): 8316-8324. Abstract

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Guirgis, Bassem S. S., Claudia Sa e Cunha, Ines Gomes, Miguel Cavadas, Isabel Silva, Goncalo Doria, Gregory L. Blatch, Pedro V. Baptista, Eulalia Pereira, Hassan M. E. Azzazy, Maria M. Mota, Miguel Prudencio, and Ricardo Franco. "Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection." Analytical and Bioanalytical Chemistry 402 (2012): 1019-1027. Abstract

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Sanz, Vanesa, Joao Conde, Alfredo Ambrosone, Yulan Hernandez, Valentina Marchesasno, Giovani G. Estrada, Manuel R. Ibarra, Pedro V. Baptista, Furong Tian, Claudia Tortiglione, and Jesus M. de la Fuente. "Multifunctional gold nanoparticles for gene silencing." Abstracts of Papers of the American Chemical Society 243 (2012). Abstract

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Doria, G., J. Conde, B. Veigas, L. Giestas, C. Almeida, M. Assunção, J. Rosa, and P. V. Baptista. "Noble metal nanoparticles for biosensing applications." Sensors (Basel) 12 (2012): 1657-87. AbstractWebsite

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2010
Costa, Pedro, Ana Amaro, Ana Botelho, João Inácio, and Pedro V. Baptista. "Gold nanoprobes assay for identification of mycobacteria from the Mycobacterium tuberculosis complex." Clin Microbiol Infect. 16 (2010): 1464-1469.
Bernacka-Wojcik, Iwona, Rohan Senadeera, Pawel Jerzy Wojcik, Leonardo Bione Silva, Gonçalo Doria, Pedro Baptista, Hugo Aguas, Elvira Fortunato, and Rodrigo Martins. "Inkjet printed and "doctor blade" TiO2 photodetectors for DNA biosensors." Biosens. Bioelectron. 25 (2010): 1229-1234.
Costa, P., A. Amaro, A. Botelho, J. Inacio, and P. V. Baptista. "Gold nanoprobe assay for the identification of mycobacteria of the Mycobacterium tuberculosis complex." Clinical Microbiology and Infection 16 (2010): 1464-1469. Abstract

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Costa, P., A. Amaro, A. Botelho, J. Inácio, and P. V. Baptista. "Gold nanoprobe assay for the identification of mycobacteria of the Mycobacterium tuberculosis complex." Clin Microbiol Infect 16 (2010): 1464-9. AbstractWebsite

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Neves, C. S., P. Quaresma, P. V. Baptista, P. A. Carvalho, JP Araujo, E. Pereira, and P. Eaton. "New insights into the use of magnetic force microscopy to discriminate between magnetic and nonmagnetic nanoparticles." Nanotechnology 21 (2010). Abstract

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