Latest Announcements

Cellular modulation of a G-quadruplex structure found in the lung cancer-related microRNA-3196

RNA G-quadruplexes (G4s) are abundant and promising drug targets. G-rich RNA forms G4s, while GC-rich sequences form stem-loops, and their structural balance is key to RNA function. Dicer processes stem-loop structures in precursor microRNAs (pre-miRs), but G4s can interfere with this, affecting miR maturation.

Cytocompatibility, fibroblast adhesion and proliferation on surface modified 3D-printed PEEK scaffolds

Polyetheretherketone (PEEK) is a high-performance thermoplastic that, when combined with Additive Manufacturing (AM), presents considerable advantages in producing customizable implantable medical devices.

Doxorubicin-sensitive and -resistant colorectal cancer spheroid models: assessing tumor microenvironment features for therapeutic modulation

We developed three-dimensional cancer models that mimic the interactions in the TME and the tumor structure and complexity is of great relevance to cancer research and drug development.

Shrinking Cancer Research Barriers: Crafting Accessible Tumor-on-Chip

A simple method for developing ToC devices in under 10 minutes, using thermo-sensitive polystyrene sheets – “Shrinky-dinks”. The process only involves pattern engraving, layer bonding, and heat shrink to the final size.

Mild hyperthermia via gold nanoparticles and visible light irradiation for enhanced siRNA and ASO delivery in 2D and 3D tumour spheroids

Novel transfection approach for gene therapy applications in 2D and 3D tumor models based on the use of mild photothermy mediated by AuNPs combined with visible laser irradiation that might pave the way for the spatial-temporal control of gene modulation - PAPER

Membrane-localized magnetic hyperthermia promotes intracellular delivery

We use membrane-localized magnetic hyperthermia to promote the internalization of cell-impermeant probes.

Nanoparticles for gene silecinging in 2D cell culture vs. 3D tumor spheroid

Transitioning from 2D to 3D models demands an understanding of altered internalization mechanisms and microenvironmental influences.

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