Protein- and Peptide-Based Biosensors in Artificial Olfaction

Barbosa, AJM, Oliveira AR, Roque ACA.  2018.  Protein- and Peptide-Based Biosensors in Artificial Olfaction. Trends in Biotechnology. 36(12):1244-1258.


Animals’ olfactory systems rely on proteins, olfactory receptors (ORs) and
odorant-binding proteins (OBPs), as their native sensing units to detect odours.
Recent advances demonstrate that these proteins can also be employed as
molecular recognition units in gas-phase biosensors. In addition, the interactions
between odorant molecules and ORs or OBPs are a source of inspiration
for designing peptides with tunable odorant selectivity. We review recent
progress in gas biosensors employing biological units (ORs, OBPs, and peptides)
in light of future developments in artificial olfaction, emphasizing examples
where biological components have been employed to detect gas-phase

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