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2014
F. S. Silva, T, M. D. R. S. Martins L, Guedes da Silva FMC, Kuznetsov ML, Fernandes AR, Silva A, Pan C-J, Lee J-F, Hwang B-J, J. L. Pombeiro A.  2014.  Cobalt Complexes with Pyrazole Ligands as Catalyst Precursors for the Peroxidative Oxidation of Cyclohexane: X-ray Absorption Spectroscopy Studies and Biological Applications, 2014/04/01. Chemistry – An Asian Journal. 9(4):1132-1143.: WILEY-VCH Verlag AbstractWebsite
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Silva, JA, Lourenço JM, Paulino H.  2014.  Boosting Locality in Multi-version Partial Data Replication, 2014. : Universidade Nova de Lisboa2014-silva.pdf
Gomes, JF, Miranda RM, Santos TJ, Carvalho PA.  2014.  Emission of nanoparticles during friction stir welding (FSW) of aluminium alloys, 2014. Journal of Toxicology and Environmental Health - Part A: Current Issues. 77(14-16):924-930.: Taylor and Francis Inc. AbstractWebsite
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Santos, TG, Miranda RM, Vilaça P.  2014.  Friction Stir Welding assisted by electrical Joule effect, 2014. Journal of Materials Processing Technology. 214(10):2127-2133.: Elsevier Ltd AbstractWebsite
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Santos, TG, Miranda RM, Vilaça P.  2014.  Friction stir welding assisted by electrical joule effect to overcome lack of penetration in aluminium alloys, 2014. 17th Conference of the European Scientific Association on Material Forming, ESAFORM 2014. 611-612:763-772., Espoo: Trans Tech Publications Ltd AbstractWebsite
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Rodrigues, A, Gutierrez-Patricio S, Miller AZ, Saiz-Jimenez C, Wiley R, Nunes D, Vilarigues M, Macedo MF.  2014.  Fungal biodeterioration of stained-glass windows, 2014. International Biodeterioration and Biodegradation. 90:152-160. AbstractWebsite
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Vilaça, P, Santos TG, Rosado L, Miranda RM.  2014.  Innovative concept and application of EC probe for inspection of friction stir welds, 2014. International Journal of Microstructure and Materials Properties. 9(3-5):314-326.: Inderscience Enterprises Ltd. AbstractWebsite

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Santos, TG, Miranda RM, De Carvalho CCCR.  2014.  A new NDT technique based on bacterial cells to detect micro surface defects, 2014. NDT and E International. 63:43-49. AbstractWebsite
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Santos, TG, Sorger G, Vilaça P, Miranda RM.  2014.  A non-conventional technique for evaluating welded joints based on the electrical conductivity, 2014. 17th Conference of the European Scientific Association on Material Forming, ESAFORM 2014. 611-612:671-676., Espoo: Trans Tech Publications Ltd AbstractWebsite
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João, C, Vasconcelos J, Silva JC, Borges JP.  2014.  An Overview of Inverted Colloidal Crystal Systems for Tissue Engineering, 2014. Tissue Engineering Part B-Reviews. 20:437-454. AbstractWebsite

Scaffolding is at the heart of tissue engineering but the number of techniques available for turning biomaterials into scaffolds displaying the features required for a tissue engineering application is somewhat limited. Inverted colloidal crystals (ICCs) are inverse replicas of an ordered array of monodisperse colloidal particles, which organize themselves in packed long-range crystals. The literature on ICC systems has grown enormously in the past 20 years, driven by the need to find organized macroporous structures. Although replicating the structure of packed colloidal crystals (CCs) into solid structures has produced a wide range of advanced materials (e.g., photonic crystals, catalysts, and membranes) only in recent years have ICCs been evaluated as devices for medical/pharmaceutical and tissue engineering applications. The geometry, size, pore density, and interconnectivity are features of the scaffold that strongly affect the cell environment with consequences on cell adhesion, proliferation, and differentiation. ICC scaffolds are highly geometrically ordered structures with increased porosity and connectivity, which enhances oxygen and nutrient diffusion, providing optimum cellular development. In comparison to other types of scaffolds, ICCs have three major unique features: the isotropic three-dimensional environment, comprising highly uniform and size-controllable pores, and the presence of windows connecting adjacent pores. Thus far, this is the only technique that guarantees these features with a long-range order, between a few nanometers and thousands of micrometers. In this review, we present the current development status of ICC scaffolds for tissue engineering applications.

Santos, TG, Martins J, Mendes L, Miranda RM.  2014.  Process developments in FSW, 2014. 8th International Conference on Management Science and Engineering Management, ICMSEM 2014. 281:1015-1021.: Springer Verlag AbstractWebsite
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Miranda, RM, Gandra JP, Vilaca P, Quintino L, Santos TG.  2014.  Surface modification by solid state processing, 2014. Surface Modification by Solid State Processing. :1-183.: Elsevier Ltd. AbstractWebsite
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Santos, TG, Lopes N, MacHado M, Vilaça P, Miranda RM.  2014.  Surface reinforcement of AA5083-H111 by friction stir processing assisted by electrical current, 2014. Journal of Materials Processing Technology. 216:375-380.: Elsevier Ltd AbstractWebsite
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Correia, IL, Franco IS, de Sá-Nogueira I.  2014.  Towards Novel Amino Acid-Base Contacts in Gene Regulatory Proteins: AraR – A Case Study, 11. PLoS ONE. 9:e111802., Number 11: Public Library of Science AbstractWebsite

AraR is a transcription factor involved in the regulation of carbon catabolism in Bacillus subtilis. This regulator belongs to the vast GntR family of helix-turn-helix (HTH) bacterial metabolite-responsive transcription factors. In this study, AraR-DNA specific interactions were analysed by an in vitro missing-contact probing and validated using an in vivo model. We show that amino acid E30 of AraR, a highly conserved residue in GntR regulators, is indirectly responsible for the specificity of amino acid-base contacts, and that by mutating this residue it will be possible to achieve new specificities towards DNA contacts. The results highlight the importance in DNA recognition and binding of highly conserved residues across certain families of transcription factors that are located in the DNA-binding domain but not predicted to specifically contact bases on the DNA. These new findings not only contribute to a more detailed comprehension of AraR-operator interactions, but may also be useful for the establishment of a framework of rules governing protein-DNA recognition.

Mendes, LM.  2014.  100% Renewable Cities: Transition Strategies.. Urban Futures Squaring Circles: Proceedings, International Conference on Urban Futures Squaring Circles 2050. , Calouste Gulbenkian Foundation: Institute of Social Sciences of the University of Lisbon and Calouste Gulbenkian Foundation
Simão, J.  2014.  An Adaptive Java Runtime Environment for Cloud Computing. Instituto Superior Técnico.
Pina, AS, Batalha IL, Roque ACA.  2014.  Affinity Tags in Protein Purification and Peptide Enrichment: An Overview. Protein Downstream Processing: Design, Development and Application of High and Low-Resolution Methods. (Labrou, Nikolaos, Ed.).:147-168.: Springer Abstract

The reversible interaction between an affinity ligand and a complementary receptor has been widely explored in purification systems for several biomolecules. The development of tailored affinity ligands highly specific towards particular target biomolecules is one of the options in affinity purification systems. However, both genetic and chemical modifications on proteins and peptides widen the application of affinity ligand-tag receptor pairs towards universal capture and purification strategies. In particular, this chapter will focus on two case studies highly relevant for biotechnology and biomedical areas, namely, the affinity tags and receptors employed on the production of recombinant fusion proteins and the chemical modification of phosphate groups on proteins and peptides and the subsequent specific capture and enrichment, a mandatory step before further proteomic analysis.

Gaspar, D, Pimentel AC, Mendes MJ, Mateus T, Falcão BP, Leitão JP, Soares J, Araújo A, Vicente A, Filonovich SA, Águas H, Martins R, Ferreira I.  2014.  Ag and Sn Nanoparticles to Enhance the Near-Infrared Absorbance of a-Si:H Thin Films. Plasmonics. 9(5):1015–1023. AbstractWebsite

Silver (Ag) and tin (Sn) nanoparticles (NPs) were deposited by thermal evaporation onto heated glass substrates with a good control of size, shape and surface coverage. This process has the advantage of allowing the fabrication of thin-film solar cells with incorporated NPs without vacuum break, since it does not require chemical processes or post-deposition annealing. The X-ray diffraction, TEM and SEM properties are correlated with optical measurements and amorphous silicon hydrogenated (a-Si:H) films deposited on top of both types of NPs show enhanced absorbance in the near-infrared. The results are interpreted with electromagnetic modelling performed with Mie theory. A broad emission in the near-infrared region is considerably increased after covering the Ag nanoparticles with an a-Si:H layer. Such effect may be of interest for possible down-conversion mechanisms in novel photovoltaic devices.

Neves, N, Lagoa A, Calado J, do Rego BAM, Fortunato E, Martins R, Ferreira I.  2014.  Al-doped ZnO nanostructured powders by emulsion detonation synthesis – Improving materials for high quality sputtering targets manufacturing. J. Eur. Ceram. Soc.. 34(10):2325-2338. AbstractWebsite

Emulsion detonation synthesis method was used to produce undoped and Al-doped ZnO nanostructured powders (0.5–2.0 wt.% Al2O3). The synthesized powders present a controlled composition and a morphology which is independent on the doping level. The XRD results indicate wurtzite as the single phase for undoped ZnO and the presence of gahnite as secondary phase for Al-doped ZnO powders. The sintering behavior of each powder was studied based on their linear shrinkage and shrinkage rate curves, showing the high sinterability of the powders. Activation energies for densification in the earlier stage were calculated for all compositions and possible sintering mechanisms are suggested depending on the doping level. The high chemical homogeneity and sinterability and the lower electrical resistivity of the bulk Al-doped sintered samples demonstrates the feasibility of emulsion detonation synthesis for the production of high quality Al-doped ZnO powders to be used in ceramic sputtering targets manufacture.

Soares, PIP, Ferreira I, Borges JP.  2014.  Application of Hyperthermia for Cancer Treatment: Recent Patents Review. Topics in Anti-Cancer Research, Vol. 3. (Atta-ur-Rahman, Khurshid Zaman, Eds.).:342-383.: Bentham Science Publishers Abstract

Cancer is one of the main causes of death in the world and its incidence increases every day. Current treatments are insufficient and present many breaches. Hyperthermia is an old concept and was early established as a cancer treatment option, mainly in superficial cancers. More recently, the concept of intracellular hyperthermia emerged wherein magnetic particles are concentrated at the tumor site and remotely heated using an applied magnetic field to achieve hyperthermic temperatures (42-45ºC). Many patents have been registered in this area since the year 2000. This chapter presents the most relevant information organized in two main categories according to the use or not of nanotechnology. The patents without nanotechnology were divided into the following subcategories: 1) external Radio-Frequency devices; 2) hyperthermic perfusion; 3) frequency enhancers; 4) applying heat to the target site using a catheter; and 5) injection of magnetic and ferroelectric particles. The patents with nanotechnology were divided into three subcategories: 1) hyperthermia devices; 2) nanoparticles; and 3) nanostructures. The use of magnetic nanoparticles is a very promising treatment approach since it may be used for diagnostic and treatment. Magnetic nanoparticle could be applied to detect and diagnose the tumor and to carry a pharmacological active drug to be delivered in the tumor site or apply hyperthermia through an external magnetic field.

Soares, PIP, Ferreira IMM, Borges JPMR.  2014.  Application of hyperthermia for cancer treatment: recent patents review. Topics in anti-cancer research. :342-383., USA: Bentham Science Publishers Abstract

Cancer is one of the main causes of death in the world and its incidence increases every
day. Current treatments are insufficient and present many breaches. Hyperthermia is an old
concept and was early established as a cancer treatment option, mainly in superficial
cancers. More recently, the concept of intracellular hyperthermia emerged wherein magnetic
particles are concentrated at the tumor site and remotely heated using an applied magnetic
field to achieve hyperthermic temperatures (42-45ºC). Many patents have been registered in
this area since the year 2000. This chapter presents the most relevant information organized
in two main categories according to the use or not of nanotechnology.

Silva, J, Fernandes AR, Baptista PV.  2014.  Application of Nanotechnology in Drug Delivery. Application of Nanotechnology in Drug Delivery. (Ali Demir Sezer, Ed.)., Rijeka: InTech, Chapters published application_of_nanotechnology_in_drug_delivery.pdf
Nunes, CI, Brás JL, Najmudin S, Moura JJG, Moura I, Carepo M.  2014.  ArsC3 from Desulfovibrio alaskensis G20, a cation and sulfate-independent highly efficient arsenate reductase. J Biol Inorg Chem. 19:1277-1285.
Veigas, B, Fernandes AR, Baptista PV.  2014.  AuNPs for identification of molecular signatures of resistance. Front Microbiol. 5:455.14veigasfm.pdf
Atilano, ML, Pereira PM, Vaz F, Catalão MJ, Reed P, Grilo IR, Sobral RG, Ligoxygakis P, Pinho MG, Filipe SR.  2014.  Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the Drosophila innate immune system. eLife. 3:e02277.
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