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2015
Poggi, F, Firmino A, Amado MP.  2015.  Energy supply-storage models for Rural Net-Zero Communities – An integrated approach. EMER 2015. :167-172., Madrid: ISBN-10: 1-62734-559-0; ISBN-13: 978-1-62734-559-0
Carvalho, F, Atilano ML, Pombinho R, Covas G, Gallo RL, Filipe SR, Sousa S, Cabanes D.  2015.  L-Rhamnosylation of Listeria monocytogenes wall teichoic acids promotes resistance to antimicrobial peptides by delaying interaction with the membrane. PLoS Pathogens. 11:e1004919.
Albuquerque, I, Almeida T.  2015.  A light in the dark: a conceptual approach to the creative use of light in contemporary art. 14° Encontro Internacional de Arte e Tecnologia. , Aveiro, Portugal: Universidade de Aveiro
Fortes, P, Alvarenga A, Seixas J, Rodrigues S.  2015.  Long term energy scenarios: Bridging the gap between socio-economic storylines and energy Modeling. Technological Forecasting & Social Change. 91:161-178.Website
Poggi, F, Firmino A, Amado MP.  2015.  Moving Forward on Sustainable Energy Transitions: The Smart Rural. European Journal of Sustainable Development - DOI:10.14207/ejsd.2015.v4n2p43. 4(2):43-50.
A. C. Marques, L. Santos, M. N. Costa, J. M. Dantas, P. Duarte, A. Gonçalves, R. Martins, C. A. Salgueiro, Fortunato E.  2015.  Office Paper Platform for Bioelectrochromic Detection of Electrochemically Active Bacteria using Tungsten Trioxide Nanoprobes. Nature Publishing Group Scientific Reports. 5
Grosso, AR, Leite AP, Carvalho S, Matos MR, Martins FB, Vítor AC, Desterro JM, Carmo-fonseca M, de Almeida SF.  2015.  Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma. eLife. 4:e09214. AbstractWebsite

Aberrant expression of cancer genes and non-canonical RNA species is a hallmark of cancer. However, the mechanisms driving such atypical gene expression programs are incompletely understood. Here, our transcriptional profiling of a cohort of 50 primary clear cell renal cell carcinoma (ccRCC) samples from The Cancer Genome Atlas (TCGA) reveals that transcription read-through beyond the termination site is a source of transcriptome diversity in cancer cells. Amongst the genes most frequently mutated in ccRCC, we identified SETD2 inactivation as a potent enhancer of transcription read-through. We further show that invasion of neighbouring genes and generation of RNA chimeras are functional outcomes of transcription read-through. We identified the BCL2 oncogene as one of such invaded genes and detected a novel chimera, the CTSC-RAB38, in 20% of ccRCC samples. Collectively, our data highlight a novel link between transcription read-through and aberrant expression of oncogenes and chimeric transcripts that is prevalent in cancer.

Amado, MP, Poggi F.  2015.  Planning PV power plants in sub-Saharan African countries. The case of Fogo Island – Cabo Verde. Materials and technologies for energy efficiency. (Antonio Méndez-Vilas, Ed.).:286., London, UK: BrownWalker Pres, ISBN-13: 978-1-62734-559-0
Restani, RB, Conde J, Pires RF, Martins P, Fernandes AR, Baptista PV, Bonifácio VDB, Aguiar-Ricardo A.  2015.  POxylated polyurea dendrimers: Smart core-shell vectors with IC50 lowering capacity. Macromol. Biosci.. AbstractWebsite

The design and preparation of highly efficient drug delivery platforms using green methodologies is at the forefront of nanotherapeutics research. POxylated polyurea dendrimers are efficiently synthesized using a supercritical-assisted polymerization in carbon dioxide. These fluorescent, pH-responsive and water-soluble core-shell smart nanocarriers show low toxicity in terms of cell viability and absence of glutathione depletion, two of the major side effect limitations of current vectors. The materials are also found to act as good transfection agents, through a mechanism involving an endosomal pathway, being able to reduce 100-fold the IC50 of paclitaxel.

Cavique, M, Flores J, Amado MP, Gonçalves-Coelho A, Mourão A.  2015.  A preliminary check of the refurbishing large office buildings to a zero energy condition. Procedia CIRP. 34(DOI: 10.1016/j.procir.2015.07.054):193-198.
Mano, F, Aroso I, Barreiros S, Borges JP, Reis R, Duarte AR, Paiva A.  2015.  Production of Poly(vinyl alcohol) (PVA) Fibers with Encapsulated Natural Deep Eutectic Solvent (NADES) Using Electrospinning. ACS Sustainable Chemistry & Engineering. 3(10):2504–2509. AbstractWebsite

Functionalized electrospun fibers are of great interest for biomedical applications such as in the design of drug delivery systems. Nevertheless, in some cases the molecules of interest have poor solubility in water or have high melting temperatures. These drawbacks can be overcome using deep eutectic solvents. In this work, poly(vinyl alcohol) (PVA), a common biodegradable biopolymer, was used to produce new functionalized fibers with the eutectic mixture choline chloride:citric acid in a molar ratio of (1:1) ChCl:CA (1:1), which was used as a model system. Fibers were produced from an aqueous solution with 7.8% (w/v) and 9.8% (w/v) of 95% hydrolyzed PVA and a 2% (v/v) of ChCl:CA (1:1). Smooth, uniform fibers with an average diameter of 0.4 μm were obtained with a content of 19.8 wt % of ChCl:CA (1:1) encapsulated.

Aquino, AS, Bernard FL, Borges JV, Mafra L, Dalla Vecchia F, Vieira MO, Ligabue R, Seferin M, Chaban VV, Cabrita EJ, Einloft S.  2015.  Rationalizing the role of the anion in CO2 capture and conversion using imidazolium-based ionic liquid modified mesoporous silica. RSC Advances. 5:64220-64227., Number {79}, {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND}: {ROYAL SOC CHEMISTRY} Abstract

Covalently supported ionic liquids in mesoporous materials were prepared by grafting 1-methyl-3-(3-trimethoxysylilpropyl)imidazolium chloride in MCM-41. Subsequently, the {[}Cl-] anion was changed to {[}BF4-], {[}PF6-] or {[}Tf2N-]. These materials that present an advantageous combination of the properties of mesoporous solid materials and ionic liquids were evaluated for CO2 sorption as well as catalysts for CO2 conversion into cyclic carbonate using propylene oxide. The material with the {[}Cl-] anion had the best performance for both CO2 sorption and conversion. A CO2 sorption of 11 w/w% on the adsorbent was achieved and the cycloaddition reaction exhibited a conversion of 67% with 82% selectivity with the catalyst remaining active after 5 cycles, proving that the same sorbent/catalyst setup can be used for both CO2 capture and conversion. Based on the experimental data and electronic-structure numerical simulations, we have hypothesized two major reasons why chloride out performs other anions when adsorbed on MCM-41 unlike unsupported ionic liquids.

Araújo, N.  2015.  A reindustrialização de Portugal num contexto de crise e hegemonia industrial dos países emergentes. IET Working Papers Series. 2015(3):20. AbstractWebsite

This working paper aimed to understand the importance and the role of Industry for the Portuguese' economic recovery, integrated in a context of progressive deindustrialisation over the last few years, and simultaneously an impressive growth and domain over some production sectors by emergent countries, associated with the 2008 crisis. We intended to analyse this problematic in both national and European levels, bringing into context the national industry, identifying the causes for the progressive abandon of the industry and its consequences. To identify the main stakeholders and their role on the reindustrialization process. To identify policies and instruments contributing to the promotion of this reindustrialisation and main conclusions.

Silveira, CM, Quintas PO, Moura I, Moura JJG, Hildebrandt P, Almeida MG, Todorovic S.  2015.  SERR spectroelectrochemical study of cytochrome cd1 nitrite reductase co-immobilized with physiological redox partner cytochrome c552 on biocompatible metal electrodes. Plos One. 10:e0129940.
Reed, P, Atilano ML, Alves R, Hoiczyk E, Sher X, Reichmann NT, Pereira PM, Roemer T, Filipe SR, Pereira-Leal JB, Ligoxygakis P, Pinho MG.  2015.  Staphylococcus aureus survives with a minimal peptidoglycan synthesis machinery but sacrifices virulence and antibiotic resistance. PLoS Pathogens. 11:e1004891.
Gonçalves, L, Santos Z, Amado MP, Craveiro I, Cabral J, Lapão L, Alves D, Simões R.  2015.  Urban Planning and Health Inequities: looking in a small-scale in a City of Cape Verde. PlosOne Journal. (DOI: 10.1371/journal.pone.0142955): DOI: 10.1371/journal.pone.0142955
Boavida, N.  2015.  The use and influence of indicators in decisions about technology innovation: Quantitative results from questionnaires in Portugal. Scientific Knowledge and the Transgression of Boundaries. (Krings, Bettina, et al, Eds.)., Berlin: Springer
Moro, AJ, Rome B, Aguilo E, Arcau J, Puttreddy R, Rissanen K, Lima JC, Rodriguez L.  2015.  A coumarin based gold(I)-alkynyl complex: a new class of supramolecular hydrogelators. Organic & Biomolecular Chemistry. 13:2026-2033., Number 7 AbstractWebsite
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Silva, SA, Bonifacio VDB, Raje VP, Branco PS, Machado PFB, Correia IJ, Aguiar-Ricardo A.  2015.  Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging. RSC ADVANCES. 5:10733-10738., Number 14 Abstract
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Nascimento, SMC, Linhares JMM, Joao CAR, Amano K, Montagner C, Melo MJ, Vilarigues M.  2015.  Estimating the Colors of Paintings. Computational Color Imaging, Cciw 2015. 9016(Tremeau, A., Schettini, R., Tominaga, S., Eds.).:236-242. Abstract
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Fundo, JF, Amaro AL, Madureira AR, Carvalho A, Feio G, Silva CLM, Quintas MAC.  2015.  Fresh-cut melon quality during storage: An NMR study of water transverse relaxation time. Journal of Food Engineering. 167:71-76. AbstractWebsite

Molecular mobility is a fundamental parameter which reflects the dynamic properties of food components and contributes to food degradation reactions comprehension. Fresh-cut fruits have become an important food market segment. However, processing of fruits promotes faster its physiological deterioration, biochemical changes and microbial degradation. The purpose of this work was to use NMR methodology as a tool to evaluate fresh-cut fruit quality, during storage at refrigerated conditions. The fresh-cut melon transverse relaxation time (T-2) was measured for a period of 7 days of storage at 5 degrees C. The relationship between the obtained values, microstructure and quality parameters was investigated. In general, results show the existence of one class of water fluidity in the system, the one present in cells after processing. T-2, a measure of this fluidity, is affected by the processing and storage time. Also, it is possible to find a close relationships between T-2 and quality parameters of total colour difference (TCD), firmness and a(w). As T-2 increases TCD also increases, while firmness and aw decrease. These results highlight the usefulness of NMR methodology application in food science. (C) 2015 Elsevier Ltd. All rights reserved.

Kempener, R, Assoumou E, Chiodi A, Ciorba U, Gaeta M, Gielen D, Hamasaki H, Kanudia A, Kober T, Labriet M, Maïzi N, ÓGallachóir B, Saygin D, Seixas J, Wagner N, Wright E.  2015.  A Global Renewable Energy Roadmap: Comparing Energy Systems Models with IRENA’s REmap 2030 Project. Informing Energy and Climate Policies Using Energy Systems Models. 30(George Giannakidis, Labriet, Maryse, Brian ÓGallachóir, GianCarlo Tosato, Eds.).:43-67.: Springer International Publishing Abstract
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Azevedo, G, Domingues B, Abreu H, Sousa-Pinto I, Feio G, Hilliou L.  2015.  Impact of cultivation of Mastocarpus stellatus in IMTA on the seaweeds chemistry and hybrid carrageenan properties. Carbohydr Polym. 116:140-8. AbstractWebsite

The biomass yield potential of Mastocarpus stellatus, a commercially attractive carrageenophyte for foods and pharmaceutics, was investigated by cultivating the seaweeds in the nutrient-rich outflow of a commercial fish farm. Results from two consecutive 4 weeks experiments indicate that the cultivation of this seaweed produces a mean biomass of 21 to 40.6 gDW m(-2) day(-1) depending on the time of the experiment. DRIFT and CP-MAS NMR analyses of seaweeds indicate that cultivation during May affected quantitatively the seaweeds chemistry, and thus the chemical and gelling properties of native extracts of kappa/iota-hybrid carrageenan (KI). Overall, algal growth leads to the production of more sulphated KI, the percentage increase varying between 27% and 44% for the two experiments. However, alkali treatment of seaweeds before extraction reduces the variations in gelling properties of KI induced by the algal growth. This study demonstrates the capacity of growing M. stellatus in an integrated multi-trophic aquaculture system for the sustainable production of high value polysaccharides.

Avo, J, Cidade MT, Rodriguez V, Lima JC, Jorge Parola A.  2015.  Photorheological Ionic Liquids. Journal of Physical Chemistry B. 119:6680-6685., Number 22 AbstractWebsite
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Alves, BM, Borlido L, Rosa SASL, Silva MFF, Aires-Barros MR, Roque ACA, Azevedo AM.  2015.  Purification of human antibodies from animal cell cultures using gum arabic coated magnetic particles. Journal of Chemical Technology & Biotechnology. 90:838–846., Number 5: John Wiley & Sons, Ltd AbstractWebsite

BACKGROUND The emergence of monoclonal antibodies (mAbs) as new biopharmaceutical products requires the development of new purification methods that are not only effective but are able to reduce production costs. To address the problematic recovery of mAbs, gum arabic (GA) coated magnetic particles (MPs) were used for the purification of human antibodies from animal cells supernatants. RESULTS MPs were synthesized via co-precipitation and exhibited a spherical-like physical aspect, with an average hydrodynamic diameter of 473 nm and a zeta potential of –26 mV. The adsorption and elution of IgG on these adsorbents was thoroughly studied. Adsorption of human IgG was enhanced at pH 6, for which a qmax of 244 mg IgG g−1 MPs and Kd of 25 mg L−1 were obtained. Increasing salt concentrations at a basic pH (1 mol L−1 NaCl at pH 11) were found to improve the elution of bound IgG. The MPs were challenged with an artificial protein mixture containing human IgG, albumin, insulin and apo-transferrin. An overall yield of 84% was achieved, retrieving 92% of bound IgG. CONCLUSIONS MPs were successfully used for the capture of monoclonal antibodies from two distinct mammalian cell cultures, a Chinese hamster ovary (CHO) and a hybridoma cell culture supernatants. The elution yields were high, ranging between 84% and 94%, with overall yields ranging from 72% to 88%. Final purities of 85% were reached for hybridoma cell supernatants. © 2014 Society of Chemical Industry

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