Leonardo Silva

Nanoparticles-Emerging Potential for Managing Leukemia and Lymphoma
A novel mutation in CEBPA gene in a patient with acute myeloid leukemia
A double Philadelphia chromosome-positive chronic myeloid leukemia patient, co-expressing P210(BCR-ABL1) and P195(BCR-ABL1) isoforms
GOLD NANOPROBES IN THE DIAGNOSTIC OF CHRONIC MYELOID LEUKEMIA: DETECTION OF THE E14A2 BCR-ABL TRANSCRIPT DIRECTLY IN RNA SAMPLES
Colorimetric assessment of BCR-ABL1 transcripts in clinical samples via gold nanoprobes
Scalable approach for the production of functional DNA based gold nanoprobes
One nanoprobe, two pathogens: gold nanoprobes multiplexing for point-of-care
Isothermal DNA amplification coupled to Aunanoprobes for detection of mutations associated to Rifampicin resistance in Mycobacterium tuberculosis
Quantitative real-time monitoring of RCA amplification of cancer biomarkers mediated by a flexible ion sensitive platform
AuNPs for identification of molecular signatures of resistance
Field Effect Sensors for Nucleic Acid Detection: Recent Advances and Future Perspectives
Gold on paper-paper platform for Au-nanoprobe TB detection
Au-nanoprobes for detection of SNPs associated with antibiotic resistance in Mycobacterium tuberculosis
Antibody modified gold nanoparticles for fast colorimetric screening of rheumatoid arthritis
Isothermal DNA amplification coupled to Au-nanoprobes for detection of mutations associated to Rifampicin resistance in Mycobacterium tuberculosis
Mobile based gold nanoprobe TB diagnostics for point-of-need.
Ion sensing (EIS) real-time quantitative monitorization of isothermal DNA amplification
Characterization of optoelectronic platform using an amorphous/nanocrystalline silicon biosensor for the specific identification of nucleic acid sequences based on gold nanoparticle probes
Antiproliferative activity of heterometallic sodium and potassium-dioxidovanadium(V) polymers
Multifunctional gold nanoparticles for gene silencing
Novel optoelectronic platform using an amorphous/nanocrystalline silicon biosensor for the specific identification of unamplified nucleic acid sequences based on gold nanoparticle probes
Portable optoelectronic biosensing platform for identification of mycobacteria from the Mycobacterium tuberculosis complex
Smuggling gold nanoparticles across cell types - A new role for exosomes in gene silencing
Gold-nanobeacons for real-time monitoring of RNA synthesis
Experimental photophysical characterization of fluorophores in the vicinity of gold nanoparticles
Gene Therapy in Cancer Treatment: Why Go Nano?
Infection of human keratinocytes by Streptococcus dysgalactiae subspecies dysgalactiae isolated from milk of the bovine udder
Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells
Peptide-coated gold nanoparticles for modulation of angiogenesis in vivo
Targeting Tumor Microenvironment for Cancer Therapy
Hyperthermia Induced by Gold Nanoparticles and Visible Light Photothermy Combined with Chemotherapy to Tackle Doxorubicin Sensitive and Resistant Colorectal Tumor 3D Spheroids
POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy
Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles
Synthesis of new hetero-arylidene-9(10H)-anthrone derivatives and their biological evaluation
Dual-color control of nucleotide polymerization sensed by a fluorescence actuator
Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line
Immortalization and characterization of a new canine mammary tumour cell line FR37-CMT
Targeting canine mammary tumours via gold nanoparticles functionalized with promising Co(II) and Zn(II) compounds
Light activation of transcription: photocaging of nucleotides for control over RNA polymerization
Use of cyclodextrins as scavengers of inhibitory photo-products in light controlled in vitro synthesis of RNA
Star-shaped magnetite@gold nanoparticles for protein magnetic separation and SERS detection
Light activation of transcription: photocaging of nucleotides for control over RNA polymerization
Targeting Cancer Resistance via Multifunctional Gold Nanoparticles
Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles
Combination of chemotherapy and Au-nanoparticle photothermy in the visible light to tackle doxorubicin resistance in cancer cells
Water safety screening via multiplex LAMP-Au-nanoprobe integrated approach
Fast Prototyping Microfluidics: Integrating Droplet Digital Lamp for Absolute Quantification of Cancer Biomarkers
Photothermal enhancement of chemotherapy in breast cancer by visible irradiation of Gold Nanoparticles
New insights into the use of magnetic force microscopy to discriminate between magnetic and nonmagnetic nanoparticles
Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles
Non-small cell lung cancer biomarkers and targeted therapy - two faces of the same coin fostered by nanotechnology
Identification of unamplified genomic DNA sequences using gold nanoparticle probes and a novel thin film photodetector
Nanoparticle-antagomiR based targeting of miR-31 to induce osterix and osteocalcin expression in mesenchymal stem cells
In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(IV) complex
Paper-Based SERS Platform for One-Step Screening of Tetracycline in Milk
Liposomes as Delivery System of a Sn(IV) Complex for Cancer Therapy
DNA adduct identification using gold-aptamer nanoprobes
Heteroleptic mononuclear compounds of ruthenium(II): synthesis, structural analyses, in vivo antitumor activity and in vivo toxicity on zebrafish embryost
Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies
Evidence of one-way flow bioaccumulation of gold nanoparticles across two trophic levels
Gold nanoprobe-based non-crosslinking hybridization for molecular diagnostics
Metabolic and histopathological alterations in the marine bivalve Mytilus galloprovincialis induced by chronic exposure to acrylamide
Fast nucleotide identification through fingerprinting using gold nanoparticle-based surface-assisted laser desorption/ionisation
Antiproliferative Activities of Diimine-Based Mixed Ligand Copper(II) Complexes
Occurrence of non-toxic bioemulsifiers during polyhydroxyalkanoate production by Pseudomonas strains valorizing crude glycerol by-product
Bacterial contig map of the 21q11 region associated with Alzheimer's disease and abnormal myelopoiesis in Down syndrome
Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection
Enhancement of water solubility of poorly water-soluble drugs by new biocompatible N-acetyl amino acid N-alkyl cholinium-based ionic liquids.
Construction and analysis of a sequence-ready map in 4q25: Rieger syndrome can be caused by haploinsufficiency of RIEG, but also by chromosome breaks approximate to 90 kb upstream of this gene
Coupling single base extension to a spectral codification tool for increased throughput screening
Imaging gold nanoparticles for DNA sequence recognition in biomedical applications
Gene Silencing Using Multifunctionalized Gold Nanoparticles for Cancer Therapy.
Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agents
Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics
Construction of a YAC/PAC physical map of a gene rich region in 1p13.3.
Gold-silver-alloy nanoprobes for one-pot multiplex DNA detection
Noble metal nanoparticles for biosensing applications
Nanodiagnostics: fast colorimetric method for single nucleotide polymorphism/mutation detection
A low cost, safe, disposable, rapid and self-sustainable paper-based platform for diagnostic testing: lab-on-paper
Gold nanoprobe assay for the identification of mycobacteria of the Mycobacterium tuberculosis complex
Gold nanoprobe assay for the identification of mycobacteria of the Mycobacterium tuberculosis complex
Gold Nanoparticles for Diagnostics: Advances towards Points of Care
RNAi-based glyconanoparticles trigger apoptotic pathways for in vitro and in vivo enhanced cancer-cell killing
In vivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models
Revisiting 30 years of biofunctionalization and surface chemistry of inorganic nanoparticles for nanomedicine
Noble metal nanoparticles applications in cancer.
Antibody-drug gold nanoantennas with Raman spectroscopic fingerprints for in vivo tumour theranostics
Nanomaterials for reversion of multidrug resistance in cancer: a new hope for an old idea?
Design of Multifunctional Gold Nanoparticles for In Vitro and In Vivo Gene Silencing
RNA quantification using noble metal nanoprobes: simultaneous identification of several different mRNA targets using color multiplexing and application to cancer diagnostics
Nanomaterials for reversion of multidrug resistance in cancer: a new hope for an old idea?
Nanophotonics for Molecular Diagnostics and Therapy Applications
Designing gold nanoparticles for in vivo gene silencing as a new therapeutic tool
Digital Microfluidics for Nucleic Acid Amplification
Association of FTO and PPARG polymorphisms with obesity in Portuguese women.
A Digital Microfluidics Platform for Loop-Mediated Isothermal Amplification Detection
Allele specific LAMP- gold nanoparticle for characterization of single nucleotide polymorphisms
Association of FTO and PPARG polymorphisms with obesity in Portuguese women
Anti-cancer precision theranostics: a focus on multifunctional gold nanoparticles
Real-time monitoring of PCR amplification of proto-oncogene c-MYC using a Ta₂O₅ electrolyte-insulator-semiconductor sensor
Single Nucleotide Polymorphism Detection Using Gold Nanoprobes and Bio-Microfluidic Platform With Embedded Micro lenses
Experimental optimization of a passive planar rhombic micromixer with obstacles for effective mixing in a short channel length
Gold-nanoparticle-probe-based assay for rapid and direct detection of Mycobacterium tuberculosis DNA in clinical samples
The Intracellular Number of Magnetic Nanoparticles Modulates the Apoptotic Death Pathway after Magnetic Hyperthermia Treatment
Precision nanomedicine in cancer: how far are we from personalization?
3h Gold nanobeacons: a potential nanotheranostics platform
Could gold nanoprobes be an important tool in cancer diagnostics?
Nanoparticles in Molecular Diagnostics
Gold nanoprobe-based non-crosslinking hybridization for molecular diagnostics: an update
Nanoparticles in molecular diagnostics
Nanodiagnostics: leaving the research lab to enter the clinics?
Gold nanoparticles for the development of clinical diagnosis methods
Colorimetric detection of eukaryotic gene expression with DNA-derivatized gold nanoparticles
A promising road with challenges: where are gold nanoparticles in translational research?
Gold nanoparticles for the development of clinical diagnosis methods
Structural characterization and biological properties of silver(I) tris(pyrazolyl)methane sulfonate
Tackling Multidrug Resistance in Streptococci - From Novel Biotherapeutic Strategies to Nanomedicines
Targeting Cancer Resistance via Multifunctional Gold Nanoparticles
Optical and Structural Characterization of a Chronic Myeloid Leukemia DNA Biosensor
Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”
The Important Role of the Nuclearity, Rigidity, and Solubility of Phosphane Ligands in the Biological Activity of Gold(I) Complexes
A novel BCR-ABL1 mutation in a patient with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia
GLUT1 and GLUT3 involvement in anthocyanin gastric transport- Nanobased targeted approach
Ionic Liquids and Salts from Ibuprofen as Promising Innovative Formulations of an Old Drug
Structural aspects of a trimetallic CuII derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines
Nanotheranostics Targeting the Tumor Microenvironment
Molecular Diagnostics of Chronic Myeloid Leukemia - precision medicine via gold nanoparticles
Nanoparticles—Emerging Potential for Managing Leukemia and Lymphoma
Multifunctional microfluidic chip for optical nanoprobe based RNA detection – application to Chronic Myeloid Leukemia
Synthesis, Cytotoxicity Evaluation in Human Cell Lines and in Vitro DNA Interaction of a Hetero‐Arylidene‐9(10H)‐Anthrone
Nanoparticle-antagomiR based targeting of miR-31 to induce osterix and osteocalcin expression in mesenchymal stem cells
Evaluation of cell toxicity and DNA and protein binding of green synthesized silver nanoparticles
Gold Nanoparticles for BCR-ABL1 Gene Silencing: Improving Tyrosine Kinase Inhibitor Efficacy in Chronic Myeloid Leukemia
Gold Nanoparticle Approach to the Selective Delivery of Gene Silencing in Cancer—The Case for Combined Delivery?
Gold nanobeacons for tracking gene silencing in Zebrafish
Tumor microenvironment modulation via gold nanoparticles targeting malicious exosomes: implications in cancer diagnostics and Therapy
Current trends in molecular diagnostics of chronic myeloid leukemia
Gold Nanoparticles for Diagnostics: Advances towards Points of Care
BioCode gold-nanobeacon for the detection of fusion transcripts causing chronic myeloid leukemia
Synthesis, Characterization, Thermal Properties and Antiproliferative Potential of Copper(II) 4′-phenyl-terpyridine Compounds
Liposomes as Delivery System of a Sn(IV) Complex for Cancer Therapy
Editorial: Cancer Nanotheranostics: What Have We Learned So Far?
Gold Nanotheranostics: Proof-of-Concept or Clinical Tool?
Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box
Polyurea dendrimer for efficient cytosolic siRNA delivery
Gold nanobeacons: A potential nanotheranostics platform
Experimental optimization of a passive planar rhombic micromixer with obstacles for effective mixing in a short channel length
POxylated Polyurea Dendrimers: Smart Core-Shell Vectors with IC50 Lowering Capacity
Characterization of antiproliferative potential and biological targets of a copper compound containing 4'-phenyl terpyridine
15 years on siRNA delivery: Beyond the State-of-the-Art on inorganic nanoparticles for RNAi therapeutics
Gold nanoparticle-siRNA mediated oncogene knockdown at RNA and protein level, with associated gene effects
THE CHEMISTRY AND BIOLOGY OF GOLD NANOPARTICLE-MEDIATED PHOTOTHERMAL THERAPY: PROMISES AND CHALLENGES
Gold-Nanobeacons as a Theranostic System for the Detection and Inhibition of Specific Genes
Low cost, safe, disposable, rapid and self-sustainable paper-based platform for diagnostic testing - Lab-on-Paper
Organometallic Compounds in Cancer Therapy: Past Lessons and Future Directions
Principles in genetic risk assessment
Gold Nanoparticles for DNA/RNA-Based Diagnostics
Gold nanoparticle-based theranostics: disease diagnostics and treatment using a single nanomaterial
The significance of the balance between intracellular glutathione and polyethylene glycol (PEG) for successful siRNA release from gold nanoparticles
Nanoparticles for Diagnostics and Imaging
Gold and silver nanoparticles for diagnostics of infection
Gold nanoprobes for multi loci assessment of multi-drug resistant tuberculosis
Nanodiagnostics: leaving the research lab to enter the clinics?
Characterization of genomic SNP via colorimetric detection using a single gold nanoprobe
Nanotechnology for Cancer Diagnostics and Therapy – An Update on Novel Molecular Players
Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine
Isothermal DNA amplification coupled to Au-nanoprobes for detection of mutations associated to Rifampicin resistance in Mycobacterium tuberculosis
Histopathological findings on Carassius auratus hepatopancreas upon exposure to acrylamide: correlation with genotoxicity and metabolic alterations.
Nanomaterials for reversion of multidrug resistance in cancer: a new hope for an old idea?
Coupling an universal primer to SBE combined spectral codification strategy for single nucleotide polymorphism analysis.
Plastic Compatible Sputtered Ta2O5 Sensitive Layer for Oxide Semiconductor TFT Sensors
Bio-microfluidic platform for gold nanoprobe based DNA detection—application to Mycobacterium tuberculosis
Gold-Nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis
Gold-nanobeacons for simultaneous gene specific silencing and intracellular tracking of the silencing events
Fast Nucleotide identification using gold nanoparticle-based surface assisted laser desorption/ionisation
Effect of PEG biofunctional spacers and TAT peptide on dsRNA loading on gold nanoparticles
Enhancement of antibiotic effect via gold:silver alloy nanoparticles
Modification of plasmid DNA topology by ‘histone-mimetic’ gold nanoparticles
Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis
RNA quantification with gold nanoprobes for cancer diagnostics
Gold and silver nanoparticles for clinical diagnostics - from genomics to proteomics
Nanoparticles in molecular diagnostics
Nanophotonics for Molecular Diagnostics and Therapy Applications
Experimental photophysical characterization of fluorophores on the vicinity of gold nanoparticles - deciphering disputes related to kr determination
Coupling single base extension to a spectral codification tool for increased throughput screening
In vitro transcription and translation inhibition via DNA functionalized gold-nanoparticles
pH effect on the photochemistry of 4-methylcoumarin phosphate esters: Caged-Phosphate Case Study
Development of a fast and efficient ultrasonic-based strategy for DNA fragmentation
RNA quantification using gold nanoprobes - application to cancer diagnostics
Optimizing Au-nanoprobes for specific sequence discrimination
Gold nanoprobes assay for identification of mycobacteria from the Mycobacterium tuberculosis complex
Inkjet printed and "doctor blade" TiO2 photodetectors for DNA biosensors
General FRET-based coding for application in multiplexing methods
Cancer Nanotechnology - Prospects for Cancer Diagnostics and Therapy
Light activation of transcription: photocaging of nucleotides for control over RNA polymerization
Multiplexed spectral coding for simultaneous detection of DNA hybridization reactions based on FRET
Gold Nanoparticles for the Development of Clinical Diagnosis Methods
Nanodiagnostics: Fast Colorimetric Method for Single Nucleotide Polymorphism/Mutation Detection
Gold nanoparticle based systems in genetics
Amorphous/nanocrystalline silicon biosensor for the specific identification of unamplified nucleic acid sequences using gold nanoparticle probes
Alloy metal nanoparticles for multicolor cancer diagnostics
AuAg-alloy-nanoprobes for Specific Nucleic Acid Detection
Gold nanoparticle probe-based diagnostic system for rapid and sensitive detection of Mycobacterium tuberculosis
Direct detection of mutations/SNPs using DNA-derivatised gold nanoparticles
Is the IVS2 region of the human Agamma globin gene an important regulatory region?
Nanodiagnostics for tuberculosis
Nanoparticles in molecular diagnostics. Nanoparticles in Translational Science and Medicine

Leonardo Silva

search-site

Recent pubs