Fe(III) salEen derived Schiff base complexes as potential contrast agents

Cardoso, BD, Vicente AI, Ward JBJ, Sebastiao PJ, Chavez FV, Barroso S, Carvalho A, Keely SJ, Martinho PN, Calhorda MJ.  2015.  Fe(III) salEen derived Schiff base complexes as potential contrast agents. Inorganica Chimica Acta. 432:258-266.


Three iron(III) complexes with ligands derived from N-ethyl-N-(2-aminoethyl) salicylaldiminate (H, 1; 5-Br, 2; 3-OMe, 3 substituents at the phenyl group) were prepared and the X-ray crystal structures of 1 and 2 are reported. NMR studies of solutions of these complexes in DMSO allowed for investigation of their magnetic behaviour and paramagnetic relaxation contribution. The relaxivities measured ranged from 0.35 to 0.80 mM(-1) s(-1) for proton Larmor frequencies from 0.01 to 300 MHz, in agreement with those known for other iron(III) based contrast agents. Biological studies on colonic epithelial T-84 cell monolayers showed that the compounds exert toxic effects only at concentrations higher than 100 mu M while coincidently reducing colonic epithelial secretory function. These two features make these complexes good candidates for further development in order to be used as MRI contrast agents. (C) 2015 Elsevier B.V. All rights reserved.



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