We study fundamental molecular and cellular processes involved in virulence of bacterial pathogens (Chlamydia, Legionella, and Salmonella) that cause important human diseases.

Chlamydia, Legionella, and Salmonella are intracellular bacterial pathogens that reside and multiply within eukaryotic host cells in a membranous vacuole. These three bacteria share a general virulence mechanism, consisting in the injection of effector proteins into host cells through specialized type III or type IV secretion systems.

Most of our research has been focused in studying how the molecular and cellular mode of action of Chlamydia, Legionella, and Salmonella effector proteins contributes to bacterial intracellular growth and virulence. We expect that this basic knowledge might help to develop new strategies to combat infectious diseases.

Jaime Mota
Departamento de Ciências da Vida
Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa (FCT NOVA)
2829-516 Caparica
E-mail: ljmota@fct.unl.pt
Phone: (+351) 21 294 8530 (ext. 11118)

The Laboratory of Infection Biology led by Jaime Mota is hosted at the Department of Life Sciences of FCT NOVA, and integrates the Molecular Microbiology research group of the R&D unit UCIBIO-REQUIMTE.