Coordinator's bio
Brief Bio
I am a marine biologist with an M.Sc. in Marine Ecological Modelling and Ph.D. in Environmental Science, completed in 2011, during which I became specialised in Marine Ecotoxicology. My Ph.D., fundaded by an FCT grant, was done at FCT-NOVA (at the former IMAR pole that preceded MARE-NOVA), in collaboration with the Universities of Cádiz and Córdoba (Spain). I was supervised by Maria Helena Costa, T. Àngel DelValls and Juan López Barea, respectively. My research subject concerned effects and responses of flatfish to contaminated estuarine sediments. My keen interest in 'omics', genotoxicology and histopathology arose then.
My first post-doc (2011-2015) was done at MARE-NOVA and INSA (Instituto Nacional de Saúde Dr. Ricardo Jorge), being advised by Maria Helena Costa and Maria João Silva, respectively, following a grant by FCT. This work dealt more closely with the human-marine environment interface and brought the opportunity to begin working in vitro as well. I also diversified my research activities towards, climate change, animal pathology and biotechnology. It was followed by a second post-doc at the Karolinska Institute in Stockholm, at the Department for Environmental Medicine (2015-2015), where I worked with Bengt Fadeel on Nanosafety and Nanotoxicology. At this stage I enhanced my expertise on in vitro testing, 'omics' and bioinformatics.
I returned to Portugal in 2016 to follow a position as Auxiliary Researcher at FCT-NOVA, enabled by an Investigator FCT starting grant (IF/00265/2015) aiming at starting a project and a team to work on marine biotechnology by exploring novel bioproducts from marine Polychaeta. However, I collaborate in many other research projects related to toxicology and marine science. I coordinate the SeaTox Lab at the UCIBIO research unit.
Personal identifiers
Current research projects
As PI:
GreenTech (Marine Biotechnology)
WormALL (Marine Biotechnology) [Awaiting consignment]
As researcher:
Plastox (Plastic Marine Litter) - PI: Andrew Booth (SINTEF, Norway)
3-Qs for Quality (Quality and Valuation of Seafood) - PI: Mário Diniz (DQ, FCT-UNL)
Current supervising activities
M.Sc. Students
Ana H. Mota (completed)
Mattia Silva (completed)
Ph.D. Students
Ana P. Rodrigo
Carla Martins
Post-Doctoral researchers
Jorge Lobo
Nagore Cuevas
Marta Martins
Publications and communcations
Books
1. COSTA, P.M. (2018). The Handbook of Histopathological Practices in Aquatic Environments: Guide to Histology for Environmental Toxicology. Academic Press, Cambridge, MA, USA, 292 pp. (ISBN: 978-0-12-812032-3).
Articles in peer-reviewed journals (boldface text indicates corresponding author)
76. CUEVAS, N., MARTINS, M., RODRIGO, A.P., MARTINS, C. & COSTA, P.M. (2018). Explorations on the ecological role of toxin secretion and delivery in jawless predatory Polychaeta. Scientific Reports 8, 7635 (doi: 10.1038/s41598-018-26031-1)
75. ALVES-BARROCO, C., ROMA-RODRIGUES, C., RAPOSO, L.R., BRÁS, C., DINIZ, M., COSTA, P.M., FERNANDES, A.R. & SANTOS-SANCHES, I. (2018, in press). Streptococcus dysgalactiae subsp. dysgalactiae isolated from milk of the bovine udder as emerging pathogens: In vitro and in vivo infection of human cells and zebrafish (Danio rerio) as biological models. MicrobiologyOpen (doi: 10.1002/mbo3.623)
74. CUEVAS, N., MARTINS, M. & COSTA, P.M. (2018, in press). Risk assessment of pesticides in estuaries: A review addressing the persistence of an old problem in complex environments. Ecotoxicology. (doi: 10.1007/s10646-018-1910-z)
73. BHATTACHARYA, K., SACCHETTI, C., COSTA, P.M., SOMMERTUNE, J., BRANDNER, B.D., MAGRINI, A., ROSATO, N., BOTTINI, N., BOTTINI, M. & FADEEL, B. (2018). Nitric Oxide-Dependent Degradation of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Implications for Intra-Articular Delivery. Advanced Healthcare Materials 7, 1700916 . (doi: 10.1002/adhm.201700916)
72. MARTINS, M., SILVA, A., COSTA, M.H., MIGUEL, C. & COSTA, P.M. (2018). Co-exposure to environmental carcinogens in vivo triggers neoplasia-related hallmarks in low-genotoxicity events, even after removal of insult. Scientific Reports 8, 3649. (doi: 10.1038/s41598-018-21975-w)
71. GONÇALVES, C., MARTINS, M., COSTA, M.H., COSTA, P.M. (2018). Development of a method for the detection of polystyrene microplastics in paraffin-embedded histological sections. Histochemistry and Cell Biology 149, 187–191. (doi: 10.1007/s00418-017-1613-1)
70. LÍBALOVÁ, H., COSTA, P.M., OLSSON, M., FARCAL, L., ORTELLI, S., BLOSI, M., TOPINKA, J., COSTA, A.L. & FADEEL, B. (2018). Toxicity of surface-modified copper oxide nanoparticles in a mouse macrophage cell line: Interplay of particles, surface coating and particle dissolution. Chemosphere 196, 482–493. (doi: 10.1016/j.chemosphere.2017.12.182)
69. COSTA, P.M., GOSENS, I., WILLIAMS, A., FARCAL, L., PANTANO, D., BROWN, D.M., STONE, V., CASSEE, F.R., HALAPPANAVAR, S. & FADEEL, B. (2018). Transcriptional profiling reveals gene expression changes associated with inflammation and cell proliferation following short-term inhalation exposure to copper oxide nanoparticles. Journal of Applied Toxicology 38, 385–397. (doi: 10.1002/jat.3548)
68. BHATTACHARYA, K., KILIÇ, G., COSTA, P.M. & FADEEL, B. (2017). Cytotoxicity screening and cytokine profiling of nineteen nanomaterials enables hazard ranking and grouping based on inflammogenic potential. Nanotoxicology 11, 809–826. (doi: 10.1080/17435390.2017.1363309)
67. MADEIRA, D., ARAÚJO, J., VITORINO, R., COSTA, P.M., CAPELO, J.-L., VINAGRE, C. & DINIZ, M. (2017). Molecular plasticity under ocean warming: proteomics and fitness data provides clues for a better understanding of the thermal tolerance in fish. Frontiers in Physiology 8, 825. (doi: 10.3389/fphys.2017.00825)
66. CAEIRO, S., VAZ-FERNANDES, P., MARTINHO, A.P., COSTA, P.M., SILVA, M.J., LAVINHA, J., MATIAS-DIAS, C., MACHADO, A., CASTANHEIRA, I. & COSTA, M.H. (2017). Environmental risk assessment in a contaminated estuary: An integrated weight of evidence approach as a decision support tool. Ocean & Coastal Management 143, 51–62. (doi: 10.1016/j.ocecoaman.2016.09.026)
65. RODRIGO, A.P. & COSTA, P.M. (2017). The role of the cephalopod digestive gland in the storage and detoxification of marine pollutants. Frontiers in Physiology 8, 232. (doi: 10.3389/fphys.2017.00232)
64. FERNANDES, A.R., JESUS, J., MARTINS, P., FIGUEIREDO, S., ROSA, D., MARTINS, M.R.D.R.S., CORVO, M.L., CARVALHEIRO, M.C., COSTA, P.M., BAPTISTA, P.V. (2017). Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agents. Journal of Controlled Release 245, 52–61. (doi: 10.1016/j.jconrel.2016.11.021)
63. CUEVAS, N., ZORITA, I., FRANCO, J., COSTA, P.M. & LARRETA, J. (2016). Multi-organ histopathology in gobies (Pomatoschistus spp.) for estuarine environmental risk assessment: a case study in the Ibaizabal estuary (SE Bay of Biscay). Estuarine, Coastal and Shelf Science 179, 145–154. (doi: 10.1016/j.ecss.2015.11.023)
62. MARTINS, M., FERREIRA, A.M., COSTA, M.H. & COSTA, P.M. (2016). Comparing the genotoxicity of a potentially carcinogenic and a non-carcinogenic PAH, singly and in binary combination, on peripheral blood cells of the European Sea Bass. Environmental Toxicology 31, 1307–1318. (doi: 10.1002/tox.22135)
61. MARTINS, M., SANTOS, J.M., COSTA, M.H. & COSTA, P.M. (2016). Applying quantitative and semi-quantitative histopathology to address the interaction between sediment-bound polycyclic aromatic hydrocarbons in fish gills. Ecotoxicology and Environmental Safety 131, 164–171. (doi: 10.1016/j.ecoenv.2016.04.019)
60. PEREIRA, K.C., COSTA, P.M., COSTA, M.H., LUQUE, Á., DELVALLS CASILLAS, Á. & RIBA LÓPEZ, I. (2016). Effects of the increase of temperature and CO2 concentration on polychaetae Nereis diversicolor: simulating extreme scenarios of climate change in marine sediments. Hydrobiologia 772, 161–174. (doi: 10.1007/s10750-016-2656-3)
59. COSTA, P.M. & FADEEL, B. (2016). Emerging systems biology approaches in nanotoxicology: Towards a mechanism-based understanding of nanomaterial hazard and risk. Toxicology and Applied Pharmacology 299, 101–111. (doi: 10.1016/j.taap.2015.12.014)
58. MADEIRA, D., COSTA, P.M., VINAGRE, C. & DINIZ, M. (2016). When warming hits harder: survival, cellular stress and thermal limits of Sparus aurata larvae under global change. Marine Biology 163, 1432–1793. (doi: 10.1007/s00227-016-2856-4)
57. MARTINS, C., ALVES DE MATOS, A.P., COSTA, M.H. & COSTA, P.M. (2015). Alterations in juvenile flatfish gill epithelia induced by sediment-bound toxicants: a comparative in situ and ex situ study. Marine Environmental Research 112, 122–130. (doi: 10.1016/j.marenvres.2015.10.007)
56. CUEVAS, N., ZORITA, I., COSTA, P.M. & LARRETA, J. (2015). Histopathological baseline levels and confounding factors in common sole (Solea solea) for marine environmental risk assessment. Marine Environmental Research110, 162–173. (doi: 10.1016/j.marenvres.2015.09.002)
55. MENDO, A.S., FIGUEIREDO, S., ROMA-RODRIGUES, C., VIDEIRA, P.A., MA, Z., DINIZ, M., LARGUINHO, M., COSTA, P.M., POMBEIRO, A.J.L., BAPTISTA, P.V. & FERNANDES, A.R. (2015). Characterization of antiproliferative potential and biological targets of a copper complex containing 4’-phenyl terpyridine. Journal of Biological Inorganic Chemistry 20, 935-948. (doi: 10.1007/s00775-015-1277-z)
54. DE LAPUENTE, J., LOURENÇO, J., MENDO, S., BORRÀS, M., MARTINS, M., COSTA, P.M. & PACHECO, M. (2015). The Comet Assay and its applications in the field of ecotoxicology: a mature tool that continues to expand its perspectives. Frontiers in Genetics 6, 180. (doi: 10.3389/fgene.2015.00180)
53. PINTO, M., LOURO, H., COSTA, P.M., CAEIRO, S., & SILVA, M.J. (2015). Exploring the potential interference of estuarine sediment contaminants with the DNA repair capacity of human hepatoma cells. Journal of Environmental Toxicology and Health, Part A 78, 559–570. (doi: 10.1080/15287394.2015.1006712)
52. CUEVAS, N., COSTA, P.M., FRANCO, J., LARRETA, J., QUINCONCES, I. & ZORITA, I. (2015). Histopathological indices in sole (Solea solea) and hake (Merluccius merluccius) for implementation of the European Marine Strategy Framework Directive along the Basque continental shelf (SE Bay of Biscay). Marine Pollution Bulletin 94, 185–198. (doi: 10.1016/j.marpolbul.2015.02.030)
51. CUEVAS, N., ZORITA, I., COSTA, P.M., FRANCO, J. & LARRETA, J. (2015). Development of histopathological indices in the digestive gland and gonad of mussels: integration with contamination levels and effects of confounding factors. Aquatic Toxicology 162, 151–164. (doi: 10.1016/j.aquatox.2015.03.011)
50. RODRIGO, A., COSTA, M.H., ALVES DE MATOS, A.P., CARRAPIÇO, F. & COSTA, P.M. (2015). A study on the digestive physiology of a marine polychaete (Eulalia viridis) through microanatomical changes of epithelia during the digestive cycle. Microscopy and Microanalysis 21, 91–101. (doi: 10.1017/S143192761401352X)
49. MADEIRA, D., MENDONÇA, V., DIAS, M., COSTA, P.M., VINAGRE, C. & DINIZ, M.S. (2015) Physiological, cellular and molecular thermal stress response of intertidal shrimps with different vertical distributions: Palaemon elegans and Palaemon serratus. Comparative Physiology and Biochemistry, Part A 183, 107–115. (doi: 10.1016/j.cbpa.2014.12.039)
48. MARTINS, M., SANTOS, J.M., DINIZ, M.S., FERREIRA, A.M., COSTA, M.H. & COSTA, P.M. (2015). Effects of carcinogenic versus non-carcinogenic AHR-active PAHs and their mixtures: lessons from ecological relevance. Environmental Research 138, 101–111. (doi: 10.1016/j.envres.2015.02.010)
47. MARTINS, M. & COSTA, P.M. (2015). The Comet assay in Environmental Risk Assessment of marine pollutants: applications, assets and handicaps of surveying genotoxicity in non-model organisms. Mutagenesis 30, 89–106. (doi: 10.1093/mutage/geu037)
46. COSTA, P.M., PINTO, M., VICENTE, A.M., GONÇALVES, C., RODRIGO, A.P., LOURO, H., COSTA, M.H., CAEIRO, S. & SILVA, M.J. (2014). An integrative assessment to determine the genotoxic hazard of estuarine sediments: combining cell and whole-organism responses. Frontiers in Genetics 5, 437. (doi: 10.3389/fgene.2014.00437)
45. LARGUINHO, M., COSTA, P.M., SOUSA, G., CAPELO, J.L., COSTA, M.H., DINIZ, M.S. & BAPTISTA, P.V. (2014). Histopathological findings on Carassius auratus hepatopancreas upon exposure to acrylamide: correlation with genotoxicity and metabolic alterations. Journal of Applied Toxicology 34, 1293–1302. (doi: 10.1002/jat.2936)
44. LARGUINHO, M., CORDEIRO, A., DINIZ, M.S., COSTA, P.M. & BAPTISTA, P.V. (2014). Metabolic and histopathological alterations in the marine bivalve Mytilus galloprovincialis induced by chronic exposure to acrylamide. Environmental Research 135, 55–62. (doi: 10.1016/j.envres.2014.09.004)
43. NEUPARTH, T., MARTINS, C., DE LOS SANTOS, C.B., COSTA, M.H., MARTINS, I., COSTA, P.M. & SANTOS, M.M. (2014). Hypocholesterolaemic pharmaceutical simvastatin disrupts reproduction and population growth of the amphipod Gammarus locusta at the ng/L range. Aquatic Toxicology 155, 337–347. (doi: 10.1016/j.aquatox.2014.07.009)
42. GONÇALVES, C., MARTINS, M., DINIZ, M.S., COSTA, M.H., CAEIRO, S. & COSTA, P.M. (2014). May sediment contamination be xenoestrogenic to benthic fish? A case study with Solea senegalensis. Marine Environmental Research 99C, 170–178. (doi: 10.1016/j.marenvres.2014.04.012)
41. MADEIRA, D., DIAS, M., ROMA, J., COSTA, P.M., VINAGRE, C. & DINIZ, M.S. (2014). Physiological and biochemical thermal stress response of the intertidal rock goby Gobius paganellus. Ecological Indicators 46, 232–239. (doi: 10.1016/j.ecolind.2014.06.029)
40. LOURO, H., TAVARES, A., VITAL, N., ALVERCA, E., COSTA, P.M., ZWART, E., DE JONG, W. & SILVA, M.J. (2014). Integrated analysis of the genotoxic effects of titanium dioxide nanomaterials in vivo using LacZ plasmid-based transgenic mice. Environmental and Molecular Mutagenesis 55, 500–509. (doi: 10.1002/em.21864)
39. MADEIRA, D., VINAGRE, C., COSTA, P.M. & DINIZ, M.S. (2014). Histopathological alterations, physiological limits and molecular responses of a juvenile eurytherm fish (Sparus aurata) to thermal stress. Marine Ecology Progress Series 505, 253–266. (doi: 10.3354/meps10794)
38. COSTA, P.M., RODRIGO, A.P. & COSTA, M.H. (2014). Microstructural and histochemical advances on the digestive gland of the common cuttlefish, Sepia officinalis L. Zoomorphology 133, 59–69. (doi: 10.1007/s00435-013-0201-8)
37. PINTO, M., COSTA, P.M., LOURO, H., COSTA, M.H., LAVINHA, J., CAEIRO, S. & SILVA, M.J. (2014). Determining oxidative and non-oxidative genotoxic effects driven by estuarine sediment contaminants on a human hepatoma cell line. Science of the Total Environment 478, 25–35. (doi: 10.1016/j.scitotenv.2014.01.084)
36. Conde, J., Larguinho, M., Cordeiro, A., Raposo, L.R., Costa, P.M., Santos, S., Diniz, M.S., Fernandes, A.R. & Baptista, P.V. (2014). Gold–nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis. Nanotoxicology 8, 521–532. (doi: 10.3109/17435390.2013.802821)
35. PINTO, M., COSTA, P.M., LOURO, H., COSTA, M.H., LAVINHA, J., CAEIRO, S. & SILVA M.J. (2014). Human hepatoma cells exposed to estuarine sediment contaminant extracts permitted the differentiation between cytotoxic and pro-mutagenic fractions. Environmental Pollution 185, 141–148. (doi: 10.1016/j.envpol.2013.10.034)
34. RODRIGO, A.P., COSTA, P.M., COSTA, M.H. & CAEIRO, S. (2013). Integration of sediment contamination with multi-biomarker responses in a novel potential bioindicator (Sepia officinalis) for risk assessment in impacted estuaries. Ecotoxicology 22, 1538–1554. (doi: 10.1007/s10646-013-1140-3)
33. LOBO, J., COSTA, P.M., MARCOS, M.A.L., FERREIRA, M.S.G., COSTA, M.H. & COSTA, F.O. (2013). Enhanced primers for amplification of DNA barcodes from a broad range of marine metazoans. BMC Ecology 13:14. (doi: 10.1186/1472-6785-13-34)
32. MARTINS, M., COSTA, P.M., FERREIRA, A.M. & COSTA, M.H. (2013). Comparative genotoxic and oxidative stress effects of carcinogenic and non-carcinogenic sediment-bound PAHs in the gills of a bivalve. Aquatic Toxicology142–143: 85–95. (doi: 10.1016/j.aquatox.2013.07.019)
31. GONÇALVES, C., MARTINS, M., COSTA, M.H., CAEIRO, S. & COSTA, P.M. (2013). Ecological Risk Assessment of impacted estuarine areas: integrating histological and biochemical endpoints in wild Senegalese sole. Ecotoxicology and Environmental Safety 95, 202–211. (doi: 10.1016/j.ecoenv.2013.06.004)
30. COSTA, P.M., CAEIRO, S. & COSTA, M.H. (2013). Multi–organ histological observations on juvenile Senegalese soles exposed to low concentrations of waterborne cadmium. Fish Physiology and Biochemistry 39, 143–158. (doi: 10.1007/s10695-012-9686-1)
29. COSTA, P.M., CARREIRA, S., COSTA, M.H. & CAEIRO, S. (2013). Development of histopathological indices in a commercial marine bivalve (Ruditapes decussatus) to determine environmental quality. Aquatic Toxicology 126, 442–454. (doi: 10.1016/j.aquatox.2012.08.013)
28. CARREIRA, S., COSTA, P.M., MARTINS, M., LOBO, J., COSTA, M.H. & CAEIRO, S. (2013). Ecotoxicological heterogeneity in transitional coastal habitats assessed through the integration of biomarkers and sediment contamination profiles: a case study with a commercial clam. Archives of Environmental Contamination and Toxicology 64, 97–109. (doi: 10.1007/s00244-012-9812-1)
27. COSTA, P.M., CARREIRA, S., LOBO, J. & COSTA, M.H. (2012). Molecular detection of prokaryote and protozoan parasites in the commercial bivalve Ruditapes decussatus from southern Portugal. Aquaculture 370/371, 61–67. (doi: 10.1016/j.aquaculture.2012.10.006)
26. MARTINS, M., COSTA, P.M., RAIMUNDO, J., VALE, C., FERREIRA, A.M. & COSTA, M.H. (2012). Impact of remobilized contaminants in Mytilus edulis during dredging operations in a harbour area: bioaccumulation and biomarker responses. Ecotoxicology and Environmental Safety 85, 96–103. (doi: 10.1016/j.ecoenv.2012.08.008)
25. COSTA, P.M. & COSTA, M.H. (2012). Development and application of a novel histological multichrome technique on whole–body clam histopathology. Journal of Invertebrate Pathology 110, 411–414. (doi: 10.1016/j.jip.2012.04.013)
24. Costa, P.M., Chicano–Gálvez, E., Caeiro, S., Lobo, J., Martins, M., Ferreira, A.M., Caetano, M., Vale, C., Alhama–Carmona, J., Lopez–Barea, J., DelValls, T.À. & Costa, M.H. (2012). Hepatic proteome changes in Solea senegalensis exposed to contaminated estuarine sediments: a laboratory and in situ survey. Ecotoxicology21, 1194–1207. (doi: 10.1007/s10646-012-0874-7)
23. COSTA, P.M., MILHINHOS, A.M., SIMÕES, M., MARUM, L., OLIVEIRA, A.M., COSTA, M.H. & MIGUEL, C. (2012). Determining DNA strand breakage from embryogenic cell cultures of a conifer species using the single-cell gel electrophoresis assay. Tree Genetics and Genomes 8, 425–430. (doi: 10.1007/s11295-011-0434-y)
22. COSTA, P.M., CAEIRO, S., VALE, C., DELVALLS, T.A. & COSTA, M.H. (2012). Can the integration of multiple biomarkers and sediment geochemistry aid solving the complexity of sediment risk assessment? A case study with a benthic fish. Environmental Pollution 161, 107–120. (10.1016/j.envpol.2011.10.010)
21. COSTA, P.M., MIGUEL, C., CAEIRO, S., LOBO, J., MARTINS, M., FERREIRA, A.M., CAETANO, M., VALE, C., DELVALLS, T.A. & COSTA, M.H. (2011). Transcriptomic analyses in a benthic fish exposed to contaminated estuarine sediments through laboratory and in situ bioassays. Ecotoxicology 20, 1749–1764. (doi: 10.1007/s10646-011-0708-z)
20. COSTA, P.M., NEUPARTH, T.S., CAEIRO, S., LOBO, J., MARTINS, M., FERREIRA, A.M., CAETANO, M., VALE, C., DELVALLS, T.A. & COSTA, M.H. (2011). Assessment of the genotoxic potential of contaminated estuarine sediments in fish peripheral blood: laboratory versus in situ studies. Environmental Research 111, 25–36. (doi: 10.1016/j.envres.2010.09.011)
19. COSTA, P.M., CAEIRO, S., LOBO, J., MARTINS, M., FERREIRA, A.M., CAETANO, M., VALE, C., DELVALLS, T.A. & COSTA, M.H. (2011). Estuarine ecological risk based on hepatic histopathological indices from laboratory and in situ tested fish. Marine Pollution Bulletin 62, 55–65. (doi: 10.1016/j.marpolbul.2010.09.009)
18. LOBO, J., COSTA, P.M., CAEIRO, S., MARTINS, M., FERREIRA, A.M., CAETANO, M., CESÁRIO, R., VALE, C. & COSTA, M.H. (2010). Evaluation of the potential of the common cockle (Cerastoderma edule L.) for the ecological risk assessment of estuarine sediments: bioaccumulation and biomarkers. Ecotoxicology 19, 1496–1512. (10.1007/s10646-010-0535-7)
17. COSTA, P.M., CAEIRO, S., DINIZ, M.S., LOBO, J., MARTINS, M., FERREIRA, A.M., CAETANO, M., VALE, C., DELVALLS, T.A. & COSTA, M.H. (2010). A description of chloride cell and kidney tubule alterations in the flatfish Solea senegalensis exposed to moderately contaminated estuarine sediments. Journal of Sea Research 64, 465–472. (doi: 10.1016/j.seares.2010.01.005)
16. RAIMUNDO, J., COSTA, P.M., VALE, C., COSTA, M.H. & MOURA, I. (2010). DNA damage and metal accumulation in four tissues of feral Octopus vulgaris from two coastal areas in Portugal. Ecotoxicology and Environmental Safety 73, 1543–1547. (doi: 10.1016/j.ecoenv.2010.07.034)
15. COSTA, P.M., CHICANO–GÁlVEZ, E., LÓPEZ BAREA, J., DELVALLS, T.À. & COSTA, M.H. (2010). Alterations to proteome and tissue recovery responses in fish liver caused by a short–term combination treatment with cadmium and benzo[a]pyrene. Environmental Pollution 158, 3338–3346. (doi: 10.1016/j.envpol.2010.07.030)
14. RAIMUNDO, J., COSTA, P.M., VALE, C., COSTA, M.H. & MOURA, I. (2010). Metallothioneins and trace elements in digestive gland, gills, kidney and gonads of Octopus vulgaris. Comparative Biochemistry and Physiology, Part C 152, 139–146. (doi: 10.1016/j.cbpc.2010.03.009)
13. DINIZ, M.S., PERES, I., CASTRO, L., FREITAS, A.C., ROCHA–SANTOS, T.A.P., COSTA, P.M., PEREIRA, R. & DUARTE, A.C. (2009). Effects of ECF–Kraft pulp mill effluent treated with fungi (Rhizopus oryzae) on reproductive steroids and liver CYP1A of exposed goldfish (Carassius auratus). Ecotoxicology 18, 1011–1017. (doi: 10.1007/s10646-009-0392-4)
12. COSTA, P.M., CAEIRO, S., DINIZ, M.S., LOBO, J., MARTINS, M., FERREIRA, A.M., CAETANO, M., VALE, C., DELVALLS, T.A. & COSTA, M.H. (2009). Biochemical endpoints on juvenile Solea senegalensis exposed to estuarine sediments: the effect of contaminant mixtures on metallothionein and CYP1A induction. Ecotoxicology 18, 988–1000. (doi: 10.1007/s10646-009-0373-7)
11. COSTA, P.M., DINIZ, M.S., CAEIRO, S., LOBO, J., MARTINS, M., FERREIRA, A.M., CAETANO, M., VALE, C., DELVALLS, T.A. & COSTA, M.H. (2009). Histological biomarkers in liver and gills of juvenile Solea senegalensis exposed to contaminated estuarine sediments: a weighted indices approach. Aquatic Toxicology 92, 202–212. (doi: 10.1016/j.aquatox.2008.12.009)
10. COSTA, P.M., SANTOS, H.M., PERES, I., COSTA, M.H., ALVES, S., CAPELO–MARTÍNEZ, J.L. & DINIZ, M.S. (2009). Toxicokinetics of waterborne trivalent arsenic in the freshwater bivalve Corbicula fluminea. Archives of Environmental Contamination and Toxicology 57, 338–347. (doi: 10.1007/s00244-008-9267-6)
9. COSTA, P.M. & COSTA, M.H. (2008). Biochemical and histopathological endpoints of in vivo cadmium toxicity in Sparus aurata. Ciencias Marinas 34, 349–361. (doi: 10.7773/cm.v34i3.1394)
8. DINIZ, M.S., SANTOS, H.M., COSTA, P.M., PERES, I., COSTA, M.H., ALVES, S. & CAPELO–MARTINEZ, J.L. (2008). Effects of exposure to arsenic in Corbicula fluminea: evaluation of the histological, histochemical and biochemical responses. Ciencias Marinas 34, 307–316. (doi: 10.7773/cm.v34i3.1396)
7. COSTA, P.M., LOBO, J., CAEIRO, S., MARTINS, M., FERREIRA; A.M., CAETANO, M., VALE, C., DELVALLS, T.A. & COSTA, M.H. (2008). Genotoxic damage in Solea senegalensis exposed to sediments from the Sado Estuary (Portugal): effects of metallic and organic contaminants. Mutation Research 654, 29–37. (doi: 10.1016/j.mrgentox.2008.04.007)
6. COSTA, P.M., REPOLHO, T., CAEIRO, S., DINIZ, M.E., MOURA, I. & COSTA, M.H. (2008). Modelling metallothionein induction in the liver of Sparus aurata exposed to metal–contaminated estuarine sediments. Ecotoxicology and Environmental Safety 71, 117–124. (doi: 10.1016/j.ecoenv.2007.05.012)
5. DINIZ, M.S., SANTOS, H.M., COSTA, P.M., PERES, I., COSTA, M.H. & CAPELO–MARTINEZ, J.L. (2007). Metallothionein responses in the Asiatic clam (Corbicula fluminea) after exposure to trivalent arsenic. Biomarkers 12, 589–598. (doi: 10.1080/13547500701507701)
4. SANTOS, H.M., DINIZ, M.S., COSTA, P.M., PERES, I., COSTA, M.H., ALVES, S. & CAPELO, J.L. (2007). Toxicological effects and bioaccumulation in the freshwater clam (Corbicula fluminea) following exposure to trivalent arsenic. Environmental Toxicology 22, 502–509. (doi: 10.1002/tox.20303)
3. COSTA, P.M. & COSTA, M.H. (2007). Genotoxicity assessment in fish peripheral blood: a method for a more efficient analysis of micronuclei. Journal of Fish Biology71SA, 148–151. (doi: 10.1111/j.1095-8649.2007.01548.x)
2. COSTA, P.M. (2004). First record of Diaphus dumerilii (Myctophiformes: Myctophidae) off the Portuguese mainland coast. Journal of Fish Biology. 64 1435–1438. (doi: 10.1111/j.0022-1112.2004.00386.x)
1. ALAGADOR, D.A. & COSTA, P.M. (2003) Distribution patterns of deep–sea benthopelagic fish off Algarve Coast, Portugal. Boletín. Instituto Español de Oceanografía 19, 407–417.
Book chapters
3. COSTA, P.M. & FADEEL, B. (2018). Emerging Systems Toxicology Approaches in Nanosafety Assessment. In Dhawan, A, Anderson, D., Shanker, R. (Eds.). Nanotoxicology: Experimental and Computational Perspectives. Royal Society of Chemistry, Cambridge, UK., pp. 174-202. (ISBN: 978-1-78262-158-4)
2. MARTINS, M., COSTA, P.M. (2017). The Comet assay in aquatic (eco)genotoxicology using non-conventional model organisms: relevance, constraints and prospects. In Larramendy, M. (Ed.). Ecotoxicology and Genotoxicology: Non-traditional Aquatic Models. Royal Society of Chemistry, Cambridge, UK, pp. 1-32 (ISBN: 978-1-78262-781-4).
1. LOURO, H., PINTO, M., VITAL, N., TAVARES, A.M., COSTA, P.M. & SILVA, M.J. (2014). The LacZ plasmid-based transgenic mouse model: an integrative approach to study the genotoxicity of nanomaterials. In SIERRA, M.L. & GAIVÃO, I. (Eds.). Genotoxicity and DNA repair. A Practical Approach. Humana Press/Springer, New York, pp. 451-477 (ISBN: 978-1-4939-1067-0).
Research articles in proceedings of scientific meetings
8. RODRIGO, A., COSTA, M.H. & COSTA, P.M. (2015). Microanatomical alterations in the gut of a marine polychaete (Eulalia viridis, Errantia: Phyllodocidae) during the digestive process. Microscopy and Microanalysis 21(S6), 12–13 (doi: 10.1017/S1431927614013737).
7. GONÇALVES, C., MARTINS, M., DINIZ, M.S., COSTA, M.H., CAEIRO, S. & COSTA, P.M. (2013). Endocrine disruption in soles collected from an estuarine area: comparison with sediment contamination profiles. In: BORREGO, C., MIRANDA, A.I., ARROJA, L., FIDÉLIS, T., CASTRO, E.A., GOMES, A.P. Actas da 10ª Conferência Nacional do Ambiente. Departamento de Ambiente da Universidade de Aveiro, vol. 1, pp. 57–62 (ISBN: 978–989–98673–0–7).
6. MARTINS, C., NEUPARTH, T., COSTA, M.H., SANTOS, M.M. & COSTA, P.M. (2013). Toxicological effects of a pharmaceutical, simvastatin, in Gammarus locusta: histopathological evaluation. In: BORREGO, C., MIRANDA, A.I., ARROJA, L., FIDÉLIS, T., CASTRO, E.A., GOMES, A.P. Actas da 10ª Conferência Nacional do Ambiente. Departamento de Ambiente da Universidade de Aveiro, vol. 1, pp. 45–50 (ISBN: 978–989–98673–0–7).
5. SANTOS, J., COSTA, P.M., MARTINS, M. & COSTA, M.H. (2013). Comparative effects of sediments contaminated by carcinogenic and non-carcinogenic PAHs in Dicentrarchus labrax: a semi-quantitative histopathological approach. In: BORREGO, C., MIRANDA, A.I., ARROJA, L., FIDÉLIS, T., CASTRO, E.A., GOMES, A.P. Actas da 10ª Conferência Nacional do Ambiente. Departamento de Ambiente da Universidade de Aveiro, vol. 1, pp. 51–56 (ISBN: 978–989–98673–0–7).
4. COSTA, P.M., CARRAPIÇO, F., ALVES DE MATOS, A.P. & COSTA, M.H. (2013). A microscopical study of the “chlorophylloid” pigment cells of the marine polychaete Eulalia viridis (L.). Microscopy and Microanalysis 19(S4), 15–16. (doi: 10.1017/S143192761300069X)
3. MADEIRA, D., DINIZ, M.S., ROSA, R., VINAGRE, C., COSTA, P.M., COSTA, M.H., CAEIRO, S., SANTOS, H.M., NUÑEZ, C., OLIVEIRA, E., CASTRO, L., PERES, I., LODEIRO, C. & CAPELO, J.L. (2013). Sea warming affects bream (Sparus aurata) tissues and stress proteins (HSP70). Microscopy and Microanalysis19(S4), 83–84. (doi: 10.1017/S1431927613001037)
2. CANDEIAS, M., Diniz, M.S., COSTA, P.M. & PERES, I. (2007). Contaminação e descontaminação de cobre em Carassius auratus L. 1758: efeitos histopatológicos nas brânquias e no fígado. In: BORREGO, C., MIRANDA, A.I., FIGUEIREDO, F.M., ARROJA, L., FIDÉLIS, T. (Eds.). Actas da 9ª Conferência Nacional do Ambiente. Departamento de Ambiente da Universidade de Aveiro, vol. 4, pp. 1206–1210 (ISBN: 978–972–789–230–3).
1. SANTOS, H.M., DINIZ, M.S., COSTA, P.M., PERES, I., COSTA, M.H. & J.L. CAPELO–MARTINEZ (2006). Utilização de Corbicula fluminea Mühlfeld, 1844, como indicador de contaminação por arsénio: avaliação da capacidade de resposta através da determinação de metalotioninas e arsénio nos tecidos. In: ANTUNES, C. (Ed.). Actas do III Simpósio Ibérico da bacia hidrográfica do Rio Minho. CIIMAR, pp. 79–88 (ISBN: 978–989–20–0600–0).
Invited talks
7. COSTA, P.M. (2017). Metal and metal oxide nanomaterials: Applications, hazards and novel approaches to risk assessment. Nanotoxicology and Micropollution. UNINOVA, Caparica (Portugal), November 22nd, 2017. Invitation by NANU - Núcleo de Nanotecnologia da FCT-UNL.
6. COSTA, P.M. (2015). Advances in the structure of the Cephalopod digestive gland: On the microanatomy of a polyvalent organ. Workshop on Digestive system in cephalopods, FA1301 COST Action. Cascais (Portugal), November 24th, 2015. Invitation by Dr. Giovanna Ponte.
5. COSTA, P.M. (2015). New challenges and old problems: On a toxicologist’s perspective on environmental and human health. Seminar on Toxicology. Institute for Environmental Medicine, Karolinska Institutet, Stockholm (Sweden), May 27th, 2015. Invitation by Dr. Bengt Fadeel.
4. COSTA, P.M. (2014). Dilution is (definitely) not the solution to pollution: tackling the stormy seas of Marine Environmental Toxicology. Seminar on Environmental Toxicology. Department of Biology, Faculty of Mathematics and Natural Sciences, University of Bergen, Bergen (Norway), August 7th, 2014. Invitation by Dr. Anders Gokøyr.
3. COSTA, P.M. (2014). Microscopy studies of marine invertebrates: from physiology and pathology to biotechnological applications. Egas Moniz Symposium on Electron Microscopy. Egas Moniz, Cooperativa de Ensino CRL, Monte de Caparica (Portugal), May 12th, 2014. Invitation by Dr.A.P. Alves de Matos.
2. COSTA, P.M. (2013). Effects on commercial species and the estuarine environment. HERA project Public seminar – Environmental risk assessment of a contaminated estuarine environment: the Sado Estuary Case study. Gulbenkian Foundation, Lisbon (Portugal), October 7th, 2013. Invitation by Dr. Sandra Caeiro.
1. COSTA, P.M. (2012). Dyes and lies: histology and histochemistry in metal toxicology. Workshop on toxicology of non–essential metals. CESAM/Universidade de Aveiro, Aveiro (Portugal), January 13th, 2012. Invitation by Dr. Cláudia Mieiro.
Pedro M. Costa