PROJECTS

PROJECT DETAILS:


A) Improved Dendritic cell-based vaccines for cancer treatment:

Aim: To identify the role of glycans expressed by human dendritic cells and use glycoengineering to improve dendritic cell based vaccines.

_______________________________________________________________

B) Glycans involved in haematogenous cell migration:


Aim: To identify the role of glycans expressed by human dendritic cells and cancer cells that contribute to transendothelial migration.

________________________________________________________________

C) Bispecific antibodies for breast cancer treatment:

Aim: To develop therapeutics to treat breast cancer that specifically target cancer cells, and simultaneously engage patient’s immune system to kill these tumor cells.

_________________________________________________________________

D) Host-pathogen interaction - In vitro model based on human dendritic cell functions:

Aim: to address mechanisms of immune evasion by bacteria.

_________________________________________________________________________

E) In vivo model of skin/ surgery infection  using immunocompetent rats:


Aim: to compare bacteria growth in skin or surgical wounds, to compare immune response after evasion, to test anti-microbial drugs and drug-delivery systems. and

use
glycoengineering to improve dendritic cell based vaccines.