PROJECTS

PROJECT DETAILS:


A) Improved Dendritic cell-based vaccines for cancer treatment:

Aim: To identify the role of glycans expressed by human dendritic cells and use glycoengineering to improve dendritic cell based vaccines.

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B) Glycans involved in haematogenous cell migration:


Aim: To identify the role of glycans expressed by human dendritic cells and cancer cells that contribute to transendothelial migration.

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C) Bispecific antibodies for breast cancer treatment:

Aim: To develop therapeutics to treat breast cancer that specifically target cancer cells, and simultaneously engage patient’s immune system to kill these tumor cells.

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D) Host-pathogen interaction - In vitro model based on human dendritic cell functions:

Aim: to address mechanisms of immune evasion by bacteria.

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E) In vivo model of skin/ surgery infection  using immunocompetent rats:


Aim: to compare bacteria growth in skin or surgical wounds, to compare immune response after evasion, to test anti-microbial drugs and drug-delivery systems. and

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F) SARS-CoV-2 in vitro assays - role of glycans in infection and as therapeutic targets:

Aim: understand the role of glycans in SARS-CoV-2 infection and the possibility of using glycan-based approaches to counterattack this infection. A) evaluate S protein anti-glycan antibodies and nutraceutical glycans to neutralized SARS-CoV-2. B) characterize the glycosylation profile of SARS-CoV-2 S protein after synthesis in cells with aberrant glycosylation (cancer cells and CDG patient-derived cells), as well as to test the SARS-CoV-2 infectivity rates in these cells, using a viral vector coated with the S protein.

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G) ProDGNE - Novel therapeutic approaches to target GNE myopathy - Horizon 2020 EJP RD Joint Transnational

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H) FCT, RESEARCH 4 COVID-19: "GLYCOVID19 - Testing existing glycan-based drugs to neutralize SARS-CoV-2"


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I) Women in Entrepreneurship Roadshow, Lisbon 2019


use
glycoengineering to improve dendritic cell based vaccines.