Our group focuses on the physiological and pathological roles of human cell glycans. Glycans are involved in virtually all biological processes, thus influencing the development, growth, and functioning of cells and organisms. Our main goals are to identify novel therapeutic targets and to integrate this knowledge into the development of innovative immunotherapies, such as antibody-based approaches and dendritic cell-based vaccines. We have identified aberrant glycosylation in cancer cells that enable cancer cell activation, invasion, and metastasis, and suppress the immune function. In immune cells, our seminal observations have demonstrated fundamental roles of cell surface glycans in modulating the immune potency of dendritic cells and their therapeutic potential.