Free Marine natural products databases for biotechnology and bioengineering

Barbosa, AJM, Roque ACA.  2019.  Free Marine natural products databases for biotechnology and bioengineering. Biotechnology Journal. -(-):-.


Marine organisms and microorganisms are a source of natural compounds with unique chemical features. These chemical properties are useful for the discovery of new functions and applications of Marine Natural Products (MNP). To extensively exploit the potential implementations of MNPs, they are gathered in chemical databases consenting their study and screening for applications of biotechnological interest. However, classification of MNPs is currently poor in generic chemical databases. The present availability of free‐access focused MNPs databases is scarce and the molecular diversity of these databases is still very low when compared to paid‐access ones. In this review paper, the current scenario of free‐access MNP databases is presented as well as the hindrances involved in their development, mainly compound dereplication. Examples and opportunities on using freely accessible MNP databases in several important areas of biotechnology are also assessed. The scope of this paper is as well to notify the latent potential of these information sources for the discovery and development of new MNPs in biotechnology, and push future efforts to develop a public domain MNP database freely available for the scientific community.

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