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2011
Barros, MT, Mouquinho AI, Petrova KT, Saavedra MD, Sotomayor JC.  2011.  Fast synthesis employing a microwave assisted neat protocol of new monomers potentially useful for the preparation of PDLC films. Cent. Eur. J. Chem.. 9(4):557-566.
Mouquinho, A, Saavedra M, Maiau A, Petrova K, Barros MT, Figueirinhas JL, Sotomayor J.  2011.  Films based on new methacrylate monomers: synthesis, characterisation and electro-optical properties. Mol. Cryst. Liq. Cryst.. 542(1):132-140.
Santos, S, Lanca V, Oliveira H, Silveira L, Marques V, Brito D, Madeira H, Bicho M, Fernandes AR.  2011.  Genetic diagnosis of hypertrophic cardiomyopathy using mass spectrometry DNA arrays and high resolution melting. Rev Port Cardiol. 30(1):7-18.11santosrpc.pdf
Barros, MT, Petrova KT, Correia-da-Silva P, Potewar TM.  2011.  Library of Mild and Economic Protocols for the Selective Derivatization of Sucrose under Microwave Irradiation. Green Chem.. 13(7):1897-1906.
Pereira, F, Aires-de-Sousa J, Bonifacio VDB, Mata P, Lobo AM.  2011.  MOLinsight: A Web Portal for the Processing of Molecular Structures by Blind Students. J. Chem. Educ.. 88(3):361–362.Website
Lopes, R, Cabral P, Canas N, Breia P, Foreid JP, Calado E, Silva R, Leal A.  2011.  N170 asymmetry as an index of inferior occipital dysfunction in patients with symptomatic occipital lobe epilepsy. Clinical Neurophysiology. 122:9-15.
Baptista, PV, Doria G, Quaresma P, Cavadas M, Neves CS, Gomes I, Eaton P, Pereira E, Franco R.  2011.  Nanoparticles in molecular diagnostics. Nanoparticles in Translational Science and Medicine. 104(11)(Villaverde, Antoni, Ed.).:427-488.: Academic Press Co., Elsevier Publishing Services
Borlido, L, Azevedo AM, Roque ACA, Aires-Barros MR.  2011.  Potential of boronic acid functionalized magnetic particles in the adsorption of human antibodies under mammalian cell culture conditions. Journal of Chromatography A. 1218(43):7821-7827. AbstractWebsite

In this work, we systematically evaluated the potential of using boronic acid functionalized magnetic particles in the capturing of human immunoglobulin G under typical mammalian cell culture conditions. For comparison, Protein A coated magnetic particles were also used. The binding pH was found to significantly influence the adsorption isotherms of boronic acid particles with the higher capacities (0.216 g IgG/g support) being observed at pH 7.4. Comparatively, this value was 0.109 g IgG/g support, for Protein A particles under the same conditions. Both particles revealed very fast adsorption kinetics with more than 70% of the maximum binding capacity being achieved in a few seconds. The effect of glucose and lactate, which are known to interact with boronic acid, was evaluated. For glucose, the binding capacity was significantly influenced by the pH and decreased as pH increased. At pH 9.5, a 70% lower binding capacity was observed for glucose concentrations as low as 0.5 g/l. The effect of lactate was less pronounced and almost pH independent reaching at most 20% decrease in binding capacity. Nevertheless, the effect of both molecules was always lower at pH 7.4. The optimization of the elution conditions enabled complete recovery of bound IgG from boronic acid particles using 50mM Tris-HCl, 200 mM sorbitol, 200 mM NaCl at pH 8.5.

Branquinho, R, Veigas B, Pinto JV, Martins R, Fortunato E, Baptista PV.  2011.  Real-time monitoring of PCR amplification of proto-oncogene c-MYC using a Ta2O5 electrolyte-insulator-semiconductor sensor. Biosens. Bioelectron.. 28:44-49..
Goncalves, G, Grasso V, Barquinha P, Pereira L, Elamurugu E, Brignone M, Martins R, Lambertini V, Fortunato E.  2011.  Role of Room Temperature Sputtered High Conductive and High Transparent Indium Zinc Oxide Film Contacts on the Performance of Orange, Green, and Blue Organic Light Emitting Diodes. Plasma Process. Polym.. 8:340-345.
Almeida, R, Ortigueira MD, Batista AG, Ktonas P.  2011.  Sleep Spindles: Decomposition, Parameterization and Applications. 19th IEEE Conference on Signal Processing and Communications Applications. Abstract

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Goncalves A., Costa C., Pereira S., Correia N., M.M. S, Barbosa P.C., L.C. R, Henriques I., R. M, Fortunato E..  2011.  Study of electrochromic devices with nanocomposites polymethacrylate hydroxyethylene resin based electrolyte. Polym. Adv. Technol.. 23:791–795.
Barros, TM, Petrova KT, Correia-da-Silva P.  2011.  Sucrose chemistry: Fast and Efficient Microwave-Assisted Protocols for the Generation of Sucrose-Containing Monomer Libraries. Microwave Heating . (U. Chandra, Ed.).:309-332., Rijeka: InTech
Moniz, AB, Dusseldorp M, Beecroft R.  2011.  Technology Assessment and Education – Introduction. Technikfolgenabschätzung – Theorie und Praxis. 18(3):4-8. AbstractWebsite

“Theory and Practice” of TA, which is referred to in the title of this journal “TATuP”, is usually addressed as a question of TA research. But science is more than research: the field of teaching requires just as much attention, both practically and theoretically. Therefore, a mere collection of individual teaching experiences and best practice examples does not provide a strong enough basis to discuss questions of TA teaching, these must also be embedded in a theoretical context and discussed in their relation to research. In this special issue, we aim to contribute to a combination of theoretical and practical approaches to the relation of TA and “Bildung”.

Baptista, AC, Martins JI, Fortunato E, Martins R, Borges JP, Ferreira I.  2011.  Thin and flexible bio-batteries made of electrospun cellulose-based membranes. Biosens Bioelectron. 26(5):2742-5., Number 5 AbstractWebsite

The present work proposes the development of a bio-battery composed by an ultrathin monolithic structure of an electrospun cellulose acetate membrane, over which was deposited metallic thin film electrodes by thermal evaporation on both surfaces. The electrochemical characterization of the bio-batteries was performed under simulated body fluids like sweat and blood plasma [salt solution–0.9% (w/w) NaCl]. Reversible electrochemical reactions were detected through the cellulose acetate structure. Thus, a stable electrochemical behavior was achieved for a bio-battery with silver and aluminum thin films as electrodes. This device exhibits the ability to supply a power density higher than 3 muW cm(-2). Finally, a bio-battery prototype was tested on a sweated skin, demonstrating the potential of applicability of this bio-device as a micropower source.

Elangovan, E, Saji KJ, Parthiban S, Goncalves G, Barquinha P, Martins R, Fortunato E.  2011.  Thin-Film Transistors Based on Indium Molybdenum Oxide Semiconductor Layers Sputtered at Room Temperature. IEEE Electron Device Lett.. 32:1391-1393.
Baptista, {PV}, c}alo Doria G{\c, Conde J.  2011.  Alloy metal nanoparticles for multicolor cancer diagnostics. Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI. : SPIE-International Society for Optical Engineering Abstract

Cancer is a multigenic complex disease where multiple gene loci contribute to the phenotype. The ability to simultaneously monitor differential expression originating from each locus results in a more accurate indicator of degree of cancerous activity than either locus alone. Metal nanoparticles have been thoroughly used as labels for in vitro identification and quantification of target sequences. We have synthesized nanoparticles with assorted noble metal compositions in an alloy format and functionalized them with thiol-modified ssDNA (nanoprobes). These nanoprobes were then used for the simultaneous specific identification of several mRNA targets involved in cancer development - one pot multicolor detection of cancer expression. The different metal composition in the alloy yield different {"}colors{"} that can be used as tags for identification of a given target. Following a non-cross-linking hybridization procedure previously developed in our group for gold nanoprobes, these multicolor nanoprobes were used for the molecular recognition of several different targets including differently spliced variants of relevant genes (e.g. gene products involved in chronic myeloid leukemia BCR, ABL, BCR-ABL fusion product). Based on the spectral signature of mixtures, before and after induced aggregation of metal nanoparticles, the correct identification could be made. Further application to differentially quantify expression of each locus in relation to another will be presented. The differences in nanoparticle stability and labeling efficiency for each metal combination composing the colloids, as well as detection capability for each nanoprobe will be discussed. Additional studies will be conducted towards allele specific expression studies.

Costa, JC, Ortigueira MD, Batista AG.  2011.  ARMA Modelling of Sleep Spindles. Second IFIP WG 5.5/SOCOLNET Doctoral Conference on Computing, Electrical and Industrial Systems. : Doceis Abstract
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Oliveira, J, Petrov V, Parola JA, Pina F, Azevedo J, Teixeira N, Bras NF, Fernandes PA, Mateus N, Ramos MJ, de Freitas V.  2011.  Chemical Behavior of Methylpyranomalvidin-3-O-glucoside in Aqueous Solution Studied by NMR and UV-Visible Spectroscopy. Journal of Physical Chemistry B. 115:1538-1545., Number 6 AbstractWebsite
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Branco, LC, Serbanovic A, da Ponte MN, Afonso CAM.  2011.  Chiral Guanidinium Ionic Liquids for Asymmetric Dihydroxylation of Olefins with Recycling of the Catalytic System by Supercritical CO2. Acs Catalysis. 1:1408-1413., Number 10 AbstractWebsite
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Gordo, J, Avo J, Parola JA, Lima JC, Pereira A, Branco PS.  2011.  Convenient Synthesis of 3-Vinyl and 3-Styryl Coumarins. Organic Letters. 13:5112-5115., Number 19 Abstract
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Santos-Silva, T, Mukhopadhyay A, Seixas JD, Bernardes GJL, Romao CC, Romao MJ.  2011.  CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II) Dicarbonyl-Lysozyme Complex. Journal of the American Chemical Society. 133:1192-1195., Number 5 AbstractWebsite
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Giestas, L, Lima JC, Baptista PV.  2011.  Coupling single base extension to a spectral codification tool for increased throughput screening. Journal of Biotechnology. 154:199-204., Number 4 Abstract
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Mukhopadhyay, A, Kladova AV, Bursakov SA, Gavel YO, Calvete JJ, Shnyrov VL, Moura I, Moura JJG, Romao MJ, Trincao J.  2011.  Crystal structure of the zinc-, cobalt-, and iron-containing adenylate kinase from Desulfovibrio gigas: a novel metal-containing adenylate kinase from Gram-negative bacteria. Journal of Biological Inorganic Chemistry. 16:51-61., Number 1 AbstractWebsite
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Brito Palma, LFF, Coito FJ, Gil P, Neves-Silva R.  2011.  Design of Adaptive PCA Controllers for SISO Systems. World Congress. 18:5483–5488., Number 1 Abstract

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