Nontoxic glasses: Preparation, structural, electrical and biological properties

Gavinho, Sílvia R., Pedro R. Prezas, Diogo J. Ramos, Isabel Sá-Nogueira, João Borges Borges, Carmo M. Lança, Jorge Carvalho Silva, Célia Henriques, Eduardo Pires, Jakka Suresh Kumar, and Manuel P. Graça. "Nontoxic glasses: Preparation, structural, electrical and biological properties." Applied Ceramics Technology 16 (2019): 1885-1894.


Bacterial infections affect about 1 in 5 patients who receive a dental implant within 5 years of surgery. To avoid the implant rejection it is necessary for the development of innovative biomaterials, with addition or substitution of the ions, for implant coatings that promote a strong bond with the new host bone and antibacterial action. The objective of this work was to synthesize a bioactive glass with different silver concentrations to evaluate their antibacterial performance. The glasses were synthesized with up to 2% silver content by melt-quenching. Structural, morphological, biological, and electrical properties of all samples were studied. The biological behavior was evaluated through cytotoxicity tests and antibacterial activity. The structural analysis shows that the introduction of silver do not promote significant changes, not altering the advantageous properties of the bioglass of the bioglass. It was verified that the glasses with a silver content from 0.5% to 2%, completely prevented the growth of both Staphylococcus aureus and Escherichia coli while being nontoxic toward mammalian cells. Therefore, these bioglasses are promising materials to be used in the production of dental implants with antimicrobial activity.

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