Funded Projects
As Principal Investigator:
• 2018/2022 - “Role of the peptidoglycan hydrolases in the interaction of Streptococcus pneumoniae with an infected host”. PTDC/BIA-MIC/30746/2017. Principal investigator: Dr. Sergio R. Filipe (FCT-NOVA, Portugal). Funding: Fundação para a Ciência e a Tecnologia.
• 2013/2015 - “Plant strategies for detection of the inflammatory bacterial peptidoglycan molecule”. PTDC/BIA-PLA/3432/2012. Principal investigator: Dr. Sergio R. Filipe (ITQB, Oeiras, Portugal). Funding: Fundação para a Ciência e a Tecnologia.
• 2011/2014 - “Small immunoactive peptidoglycan (siPGN) derivatives to modulate an host inflammatory response”. PTDC/SAU-IMU/111806/2009. Principal investigator: Dr. Sergio R. Filipe (ITQB, Oeiras, Portugal). Funding: Fundação para a Ciência e a Tecnologia.
• 2011/2014 - “Synthesis of peptidoglycan in Streptococcus pneumoniae - where, when and why is it necessary to branch?”. PTDC/BIA-MIC/111817/2009 . Principal investigator: Dr. Sergio R. Filipe (ITQB, Oeiras, Portugal). Funding: Fundação para a Ciência e a Tecnologia.
• 2011/2013: “Identification of bacterial cell wall components that interfere with peptidoglycan recognition by the host”. Research Grant from the European Society of Clinical Microbiology and Infectious Diseases ESCMID).
• 2010/2013 - “Tracking the synthesis of the Chlamydia cell wall - a biological paradox in intracellular and evasive bacteria”. PTDC/BIA-MIC/100747/2008. Principal investigator: Dr. Sergio R. Filipe (ITQB, Oeiras, Portugal). Funding: Fundação para a Ciência e a Tecnologia.
• 2008/2011 - “Contribution of the capsular polysaccharide to the inflammatory ability of the bacterial peptidoglycan”. PTDC/SAU-MMI/75696/2006. Principal investigator: Dr. Sergio R. Filipe (ITQB, Oeiras, Portugal). Funding: Fundação para a Ciência e a Tecnologia.
• 2005/2008 - “Role of bacterial cell wall on the host innate immune response”. POCI/SAU-IMI/56501/2004. Principal investigator: Dr. Sergio R. Filipe (ITQB, Oeiras, Portugal). Funding: Fundação para a Ciência e a Tecnologia.
• 2005/2009 - “Evolution and acquisition of drug resistance in MRSA”. Subcontract/ Research Agreement 2 R01 AI045738-06 (NIH – USA). Coordinator – Professor Alexander Tomasz (The Rockefeller University, New York, USA).
• 2005/2006 - “Interaction between bacterial cell wall mutants and the Drosophila host defence”. Project International Joint Project – 2004/R3-EU Europe (The Royal Society – UK). Coordinators – Dr. Petros Ligoxygakis (University of Oxford, Oxford, UK) and Dr. Sergio R. Filipe (ITQB, Oeiras, Portugal).
As Collaborator:
• 2021/2024 - "Regulation of peptidoglycan hydrolases in the bacterial pathogen Staphylococcus aureus”. PTDC/BIA-CEL/6982/2020. Principal investigator: Prof. Helena Veiga (ITQB-NOVA, Portugal). Funding: Fundação para a Ciência e a Tecnologia.
• 2018/2022 - “Molecular and cell biology of imipenem resistance in the human enteric pathogen Clostridium difficile”. PTDC/BIA-MIC/32542/2017. Principal investigator: Prof. Adriano Henriques (ITQB-NOVA, Portugal). Funding: Fundação para a Ciência e a Tecnologia.
• 2018/2022 - “Clinical significance of Mycobacterium tuberculosis cell wall structural diversity: contribution to novel mechanisms of antibiotic resistance and relevance towards tuberculosis progression and treatment”. PTDC/BIA-MIC/31233/2017. Principal investigator: Prof. Maria João Catalão (FF-UL, Portugal). Funding: Fundação para a Ciência e a Tecnologia.
• 2013/2015 - “Rethinking Bacterial Cell Wall Synthesis: a combined synthetic and enzymatic approach”. PTDC/QEQ-QOR/2132/2012. Principal investigator: Dr. Maria Manuel Marques (FCT/UNL, Portugal). Funding: Fundação para a Ciência e a Tecnologia.
• 2005/2007 - “Organization of the Staphylococcal Cell Wall Synthetic Machinery”. POCTI/BIABCM/56493/2004. Principal investigator: Dr. Mariana Gomes de Pinho (ITQB, Oeiras, Portugal). Funding: Fundação para a Ciência e a Tecnologia.
• 2005/2007 - “Regulation of Cell Wall Synthetic Genes and Enzymes in ß-Lactam Resistant Staphylococcus aureus”. POCTI/BIA-MIC/58416/2004. Principal investigator: Prof. Herminia de Lencastre (ITQB, Oeiras, Portugal). Funding: Fundação para a Ciência e a Tecnologia.