Financed Projects - PTDC/CTM/098979/2008

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Project Title: Molecular mobility, phase transformations and stability of pharmaceutical materials under nanoconfinement (http://www.fct.pt/apoios/projectos/consulta/vglobal_projecto?idProjecto=98979&idElemConcurso=2712)

Reference: PTDC/CTM/098979/2008

Main Research Area: Materials Science and Engineering

Starting date: 03-01-2010     Ending date: 30-06-2013

Funding: € 173,000.00 financed by Fundação para Ciência e Tecnologia, IP (Portugal) within the framework of the Programme “Promover a Produção Científica, o Desenvolvimento Tecnológico e a Inovação 002: Investigação Científica e Tecnológica (3599-PPCDTI)

Keywords: nanoconfinement, dielectric relaxation, crystallization, amorphisation

Project Leader
Natália de Fátima Teixeira Correia, nd.correia@fct.unl.pt

Research Team

Andreas Schoenhals (Consultant, BAM, Germany)
Alexej I. Smirnov (Consultant, NCSU, USA)
Emeline Dudognon (UMET, Univ. Lille 1, France)
Florence Danède (UMET, Univ. Lille 1, France)
Francisco Jorge Fernandes Caldeira (Requimte, FCT/UNL)
Frédéric Affouard (UMET, Univ. Lille 1, France)
Inês Alexandra Morgado do Nascimento Matos (Requimte, FCT/UNL; FCT post-doctoral fellowship)
Isabel Maria de Figueiredo Ligeiro da Fonseca (Requimte, FCT/UNL)
Marc Descamps (UMET, Univ. Lille 1)
Maria Madalena Alves Campos de Sousa Dionísio Andrade (Requimte, FCT/UNL)
Maria Margarida Canas Mendes de Almeida Cardoso (Requimte, FCT/UNL)
María Teresa Viciosa Plaza (CQFM,IST; FCT post-doctoral fellowship)
 
 

Project Fellowships

Andreia Filipa Rodrigues

Diogo Filipe Rocha Rodrigues
Gonçalo Miguel Brito dos Santos

Final Avaliation:

The main objective of the project was to study the influence of nanoconfinement on the dynamics, phase transformations and stability of pharmaceutic drugs mainly by dielectric relaxation spectroscopy (DRS) in combination with temperature modulated calorimetry (TM-DSC). The studies were done for several pharmaceutical drugs and provided fundamental knowledge beyond the development of systems that can be used for drug delivery purposes. The goals of the project were globally achieved. The output of the project in terms of indicators was excellent: 9 papers in International journals with peer-review, and 15 presentations in international/national scientific meetings. The project also strongly contributed for the advanced training: 1 Master thesis and 4 other types of theses (final works of the graduation studies) were produced. In addition, two BI grants were attributed in the framework of the project. A new technique (TM-DSC) was implemented in the host institution. Possibly, in the near future, the researchers may also think about patenting some of the developed systems.