Water soluble heterometallic potassium-dioxidovanadium(V) (K+/VO3+) complexes as potential antiproliferative agents
- Citation:
- Sutradhar, M, Fernandes AR, Silva J, Mahmudov KT, da Silva FGMC, Pombeiro AJL. 2016. Water soluble heterometallic potassium-dioxidovanadium(V) (K+/VO3+) complexes as potential antiproliferative agents. J Inorg Biochem. (155):17-25.
Abstract:
Two water soluble heterometallic potassium–dioxidovanadium polymers, [KVO2(L1)]n (1) and [KVO2(L2)(H2O)]n (2) [H2L1= (2,3-dihydroxybenzylidene)-2-hydroxybenzohydrazide and H2L2=(2,3-dihydroxybenzylidene)benzohydrazide], have been synthesized and characterized by IR, NMR, elemental analysis and single crystal X-ray diffraction. The antiproliferative potentials of 1 and 2 were examined towards human colorectal carcinoma (HCT116), and lung (A549) and breast (MCF7) adenocarcinoma cell lines. 1 exhibits a high cytotoxic activity against colorectal carcinoma cells (HCT116), with IC50 lower than those for cisplatin.