Important cytotoxic and cytostatic effects of new copper(i)-phosphane compounds with N,N, N,O and N,S bidentate ligands
- Citation:
- Morais, TS, Jousseaume Y, MF PM, Roma-Rodrigues C, Fernandes AR, Marques F, Villa de Brito MJ, Garcia MH. 2018. Important cytotoxic and cytostatic effects of new copper(i)-phosphane compounds with N,N, N,O and N,S bidentate ligands, 2018. Dalton Trans. 47(23):7819-7829.
Abstract:
A family of six phosphane Cu(i) complexes bearing N,N, N,O and N,S bidentate ligands was synthesized. All the compounds were fully characterized by classical analytical and spectroscopic methods, and five of them were also characterized by X-ray diffraction studies. All the compounds exhibit high cytotoxicity against the human breast cancer cell line MCF7 with IC50 values far lower than those found for cisplatin, a current chemotherapeutic in clinical use. Compounds 1[combining low line] and 3[combining low line] induce cell cycle arrest in the G2/M phase and cell death by apoptosis. The cytotoxic and cytostatic effects of these compounds on MCF7 cells suggest that they are suitable for further in vivo studies with breast cancer models.
Notes:
Morais, Tania SJousseaume, Yann
M Piedade, M Fatima
Roma-Rodrigues, Catarina
Fernandes, Alexandra R
Marques, Fernanda
Villa de Brito, Maria J
Garcia, M Helena
eng
England
Dalton Trans. 2018 Jun 12;47(23):7819-7829. doi: 10.1039/c8dt01653d.