Pablo J. Gonzalez

PhD Researcher, FCT NOVA
Email: p.gonzalez(at)
Tel: + 351 21 294 83 00, ext. 10967
Webpage: webpage

Research Activities - Keywords
• Biochemistry, Biophysics, Enzyme catalysis, Bioremediation, Renewable Energy Sources, Model Compounds
• Catalytic mechanism of molybdenum and tungsten containing enzymes
    (periplasmic nitrate reductase, respiratory nitrate reductase, formate dehydrogenase, aldehyde oxidoreductase)
    and heme enzymes (chlorite dismutase)
• Electronic structure characterization of metal cores in model compounds
• EPR spectroscopy (CW-EPR, ESEEM, ENDOR, HYSCORE, polycrystalline powder, single crystals)
• Enzyme catalysis (steady-state kinetics)
• Bio-electrochemistry (Protein Film Voltammetry)
• Large scale protein purification (HPLC)
• Theoretical calculations (Ab-initio, DFT)

Teaching Interests
• Bioinorganic Chemistry, Biochemistry, Enzymology, Spectroscopy

Recent Publications can be found here

Selected References
The mechanism of formate oxidation by metal-dependent formate dehydrogenases
Mota CS, Rivas MG, Brondino CD, Moura I, Moura JJG, González PJ, Cerqueira NMFSA
J Biol Inorg Chem (2011) 16:1255–1268

The crystal structure of Cupriavidus necator nitrate reductase in oxidized and partially reduced states
Coelho C, González PJ, Moura JG, Moura I, Trincão J, João Romão M
J Mol Biol (2011) 408:932-948

Kinetic, structural, and EPR studies reveal that aldehyde oxidoreductase from Desulfovibrio gigas does not need a sulfido ligand for catalysis and give evidence for a direct Mo-C interaction in a biological system
Santos-Silva T, Ferroni F, Thapper A, Marangon J, Gonzalez PJ, Rizzi AC, Moura I, Moura JJG, Romao MJ, Brondino CD
J Am Chem Soc (2009) 131:7990-7998

Structural, MALDI-TOF-MS, magnetic and spectroscopic studies of new dinuclear copper(ii), cobalt(ii) and zinc(ii) complexes containing a biomimicking l-OH bridge
Núñez C, Bastida R, Macías A, Valencia L, Neuman NI, Rizzi AC, Brondino CD, González PJ, Capelo JL, Lodeiro C
Dalton Trans (2010)39:11654-11663

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