Dissertation Themes
Master Thesis in 2021/2022
Development of new molecular probes for imaging of cancer and inflammation
New fight against tuberculosis using pharmaceutical ionic liquids
Óleos isolantes e lubrificantes: metodologias de análise
Sensing of biorelevant molecules with metal-organic framework films
Exploring synthetic approaches of purine nucleosides as potential copper chelators and cholinesterase inhibitors
Synthesis of Unnatural Amino Acids based on Hypervalent Iodine Reagents: expanding the Potential of Umpolung Reactions
A comprehensive screening study on the solubility in NADESs by using Hansen solubility parameter
Chemical engineered extracts of Portuguese biorenewable resources to the synthesis of diverse natural products hybrids towards new bioactive entities
Metabolic and Neurotoxic profiles of Synthetic Cathinones
Validação de Limpeza na Indústria Farmacêutica
Expedient synthesis of biomass-based monomers using heterogeneous catalysis: access to novel biopolymers with medicinal application
Neonicotinoides como pesticidas (insecticidas) - controle (mapeamento) ambiental e estudo do risco
Exploring the use of different triazene derivatives to fight bacteria and fungi-related infections
One-pot metal-catalyzed synthesis of azaindoles and diazaindoles
Therapeutic efficacy of novel macromolecules towards CXCR4-expressing cancer cells
Master Thesis in 2020/2021 Synthesis of Unnatural Amino Acids based on Hypervalent Iodine Reagents: expanding the Potential of Umpolung Reactions Targeted actinomycete isolation from the Estremadura Spur, taxonomic characterization and evaluation of antimicrobial potential Sustainable cellulose chemical modification in homogeneous conditions Synthesis of new phosphoglycoglycerol – evaluation as model to new putative therapeutic agents Synthesis and evaluation of phenolic metabolites and analogues Implementação e validação de um método de ensaio para análise de novos compostos emergentes em águas por SPE-GC/MS New approaches to amino-piyrrolidine guanine compounds Encapsulation of luminescent hydrophobic B(III) and Pt(II) complexes into hydrophilic functionalised polymer nanoparticles as potential Biomedical imaging tools New fight against tuberculosis using pharmaceutical ionic liquids Expanding the toolbox of chemical tools to target malaria parasites with azaindoles Luminescent compounds with Delayed Fluorescence in Aggregate State for Imaging Applications Stenhouse photoswitches as new materials for smart applicationsphosphotransferase system One-pot metal-catalyzed synthesis of azaindoles and diazaindoles Development of cromoglicate derived mesogens for NMR spectroscopy New fluorophores for proteins and nucleic acids labeling: application to cultural heritage Synthesis and in vitro evaluation of new thiosemicarbazone derivatives as biologically active compounds pH and Photoresponsive Soft Materials for Drug-Delivery Applications
Master Thesis in 2019/2020 Preparation and characterisationof arabinoxylanbiopolymers to be used as active packaging and edible films New approach to phenanthridine alkaloids by intramolecular radical cyclization Self-assembled coordination cages for encapsulation of pharmaceutical pollutants Development of bio-based binders for production of cork stoppers Design and Synthesis of Light-Responsive High-Affinity Pairs Natural inspired small organic molecules for targeting aquaporins as a novel therapeutic approach to pancreatic cancer Protein and alkaloids recover from lupine debittering leaching waters Study of the composition and elemental bioaccessibility of the macroalga Asparagopsis taxiformis and isolation of biomass fractions thereof enriched in elements of critical importance Optimization and validation of methods for the determination of proximal and lipid composition in macroalgal matrices. Characterization of several seaweeds of interest selected from the main taxonomic groups (green, brown, and red algae) CO2 reduction with formate dehydrogenase mimetic compounds Development of PRIDEs – PolymeRIc Deep Eutectic solvents - for CO2 capture
Master Thesis in 2018/2019 Multistate/Multiresponsive Host-Guest Complexes Aplicação de aminoguanidinas ciclicas em organocatálise
Functionalization of PLGA polymeric macromolecules for transformation into nanoparticles for eventual pharmaceutical application.
Molecular properties of volatile sensing materials
Identification of toxic compounds in forensic context
Synthesis of sustainable polymers to achieve protein stable white wines
Synthesis and biological activities studies of novel phenylpropanoid sugar derivatives
Síntese de um diterpeno de origem marinha
Exploring the biological role of (aza)indoles as potential new covalent drugs
New Hetero-branched sensitizers for DSSC
SugarPharma - Abordagens de Química Verde para Aumentar a Atividade Antitumoral de Ésteres de Açúcares Naturais, Encontrados em Plantas Medicinais
Síntese do alcalóide cernumidina A e suas aplicações
Exploring azaindoles structural diversity by novel metal-catalyzed approaches
Optimization of derivatization and validation of a HPLC-UV quantification method of Glyphosate and AMPA in water matrixes.
Molecular recognition of tumor-associated glycan antigens and the Siglec-9 immunomodulatory lectin.
Master Thesis in 2017/2018 Luminescent probes for ovarian cancer early detection Novel synthetic routes towards azaindoles: exploring metal-catalysed one-pot approaches
Pharmaceutically Active Nature-Inspired Ionic Fluids: A Promising Bioavailability-Enhancing Development Option for Pharmaceuticals
Fatty acids profiling in Micropterussalmoides by gas-chromatography/mass spectrometry
Development and characterization of nanoagents to treat Rheumatoid Arthritis
In vivo and in vitro studies of an ATP hydrolyzing protein from Streptococcus pneumoniae
Smart mesoporous silica glyconanoparticles for theranostics
Design and Synthesis of Small Protein-Based Scaffolds for Biocatalysis
REACTIVITY AND APPLICABILITY OF AZOLIUM SALTS
Structural and functional studies of a new class of Mycobacterium tuberculosis inhibitors
Novel small molecules to target Alzheimer’s disease
Synthesis of new triarylmethanes (TRAM) as potential autophagy agents
A rational approach towards novel modulators of necroptosis
Synthesis of tailored poly(3-hexylthiophene) nanoparticles containing thiophene‑S,S‑dioxide for electrochromic applications
Synthesis of methyl-mannoligosaccharide precursors
Síntese do alcalóide cernumidina A e suas aplicações
Novel water-soluble emitters for imaging and sensing applications
Síntese de um metabolito de origem marinha
Master Thesis in 2016/2017 Fotoindução quiral em líquidos iónicos Sustainable synthesis of heterocyclic compounds: exploring cascade reactions on a soluble polymer support Molecular recognition of MUC1 Tumor-associated antigens by lectins & antibodies
Development of in-cell NMR methodologies
Development of novel small molecules to Efficiently Inhibit Neural Tumorigenesis
Caracterização do perfil volátil da bebida de café espresso (Ristreto, Espresso ou Lungo) para os blends usados no sistema de extração Mocoffee.
Development of novel anti-cancer agents
Volatile organic compounds profile variation of olive oils blends under storage
Implementação e Validação de um método de ensaio para análise de metais em águas superficiais e águas de consumo humano por ICP/MS e/ou ICP óptico usando amostradores passivos
Synthesis of Smart Biocompatible Nanoparticles for Bio- Applications.
Untangling interactions of Bio-inspired Cresyl Violet Derivatives with essential and toxic metal ions. Studies and applications in biological samples.
Synthesis of new macromolecules with potential biological activity based on glucose
Investigation of novel sulfonylation methods
New synthetic routes for the valorization of easily accessible bio-renewable resources
Development of new functional cross-linked biopolymers
Caracterização do perfil de compostos orgânicos voláteis no ar interior do departamento de Química
Implementação e Validação de um método de ensaio para análise de compostos orgânicos em águas superficiais por GC/MS e LC-MS/MS usando amostradores passivos.
Development of new photoluminescent materials based on perovskite-like nanocrystals
Diarylethene Linkers for Supramolecular Polymers
Conversion of chitin into biologically valuable chitooligosaccharides: synthetic studies towards NAG-NAM oligosaccharides
From sugar based bio renewable resources to new chemical building blocks and bioactive molecules
Chirality, flavour and anti-oxidant behavior in selected foods
Synthesis of new macromolecules with potential biological activity based on manose
Aplicação de aminoguanidinas ciclicas em organocatálise
Master Thesis in 2015/2016 Reaction-Separation process integration in the production of cyclic carbonates from CO2 Selenium-containing purines and poliphenols: antioxidant and anti-cancer properties Synthesis and characterization of photoactive ionic liquids Coumarin-based organic chromophores: a polyfunctional substrate for diverse applications - fluorescent polymers and drug delivery carriors
Organocatalyzed Domino Reactions With α,ß-Unsaturated Carbonyl Compounds: A Theoretical Study
Development of cellulosic polymer ionic liquids as self-healing soft materials
Otimização e validação dos métodos de análise de Azoto Amoniacal, Nítrico e Kjeldahl em lamas e solos
Untangling interactions of Bio-inspired Cresyl Violet Derivatives with essential and toxic metal ions. Studies and applications in biological samples.
Aggregation Induced Emission from Ionic Liquid based Au(I) complexes and applications
Procura de novos antibióticos. Síntese, caracterização e deteminação da actividade biológica.
Isolation and identification of bioactive secondary metabolites from Streptomyces sp. strains obtained from ocean sediments from the Madeira Archipelago
Development of multifunctional composite aerosols for lung cancer therapy
Desenvolvimento e Validação de um método de ensaio para análise de haloacetonitrilos por cromatografia gasosa associada à espectrometria de massa
Optimization of the modulation parameters in GCxGC analysis
Wine volatile profiles development after contact with four different wood botanical varieties
Síntese do alcalóide cernumidina A e suas aplicações
Development of novel dual-catalyst ionic liquids and salts for asymmetric catalysis
Flavylium-Functionalized Carbon Quantum Dots
A Metabolomic/computational approach for marine natural products drug discovery
Caracterização do perfil de compostos orgânicos voláteis em seres humanos
Targeting p53-MDM2/X interactions: Design, synthesis and biological evaluation of novel small molecules
Master Thesis in 2014/2015 Caracterização de biomarcadores geoquímicos orgânicos em solos e águas subterrâneas Using N-Heterocyclic carbene (NHC) as a catalyst for methylene transfer reactions: Focus on amination reactions. Biomimetic oxidation of xenobiotics by Laccases: generation of quinoid electrophilic intermediates Quantification of Nevirapine protein adducts in HIV patients: development and validation of mass spectrometric –based method Synthesis and Structural characterization of covalent DNA adducts formed with the vasopressin antagonist Tolvaptan Synthesis of photoactive dendrimers for green photovoltaics Targeting p53-MDM2 interaction: Design, synthesis and biological evaluation of novel MDM2 inhibitors Novel synthetic strategies towards azaindoles - promising COX-2 inhibitors Exploring the delivery mechanism to tumor cells based on reversible iminoboronates New synthetic methodology for the asymmetric synthesis of carbocycles and biological evaluation Synthesis of methyl-mannoligosaccharide precursors Radioiodinated compounds for DNA-targeted radiotherapy Desenvolvimento de eléctrodos baseado em nanopartículas de WO3 para aplicação como biossensores
Use of amino acid racemization for forensic biological evidence dating Master Thesis in 2013/14 Studies Towards Modified Chitoologosaccharides: A New Aproach to NAF-MAN Moiety Síntese de muropéptidos bacterianos para estudos de interacção com a vancomicina Racionalização do mecanismo de adição de composto carbonílicos a vinil-mono e di-sulfonas, catalisado por aminas Polímeros electrocrómicos confinados em sistemas mesoporosos Electrochemical Supercapacitors of Condutive Polymers and Their Composites Application of NMR RDC´s, Relaxation and Self-Diffusion for the Study of Dynamic Processes of Small Molecules in Solution
Selectores quirais aplicados à separação cromatoráfica
Master Thesis in 2020/2021 Synthesis of Unnatural Amino Acids based on Hypervalent Iodine Reagents: expanding the Potential of Umpolung Reactions Targeted actinomycete isolation from the Estremadura Spur, taxonomic characterization and evaluation of antimicrobial potential Sustainable cellulose chemical modification in homogeneous conditions Synthesis of new phosphoglycoglycerol – evaluation as model to new putative therapeutic agents Synthesis and evaluation of phenolic metabolites and analogues Implementação e validação de um método de ensaio para análise de novos compostos emergentes em águas por SPE-GC/MS New approaches to amino-piyrrolidine guanine compounds Encapsulation of luminescent hydrophobic B(III) and Pt(II) complexes into hydrophilic functionalised polymer nanoparticles as potential Biomedical imaging tools New fight against tuberculosis using pharmaceutical ionic liquids Expanding the toolbox of chemical tools to target malaria parasites with azaindoles Luminescent compounds with Delayed Fluorescence in Aggregate State for Imaging Applications Stenhouse photoswitches as new materials for smart applicationsphosphotransferase system One-pot metal-catalyzed synthesis of azaindoles and diazaindoles Development of cromoglicate derived mesogens for NMR spectroscopy New fluorophores for proteins and nucleic acids labeling: application to cultural heritage Synthesis and in vitro evaluation of new thiosemicarbazone derivatives as biologically active compounds pH and Photoresponsive Soft Materials for Drug-Delivery Applications
Master Thesis in 2019/2020 Preparation and characterisationof arabinoxylanbiopolymers to be used as active packaging and edible films New approach to phenanthridine alkaloids by intramolecular radical cyclization Self-assembled coordination cages for encapsulation of pharmaceutical pollutants Development of bio-based binders for production of cork stoppers Design and Synthesis of Light-Responsive High-Affinity Pairs Natural inspired small organic molecules for targeting aquaporins as a novel therapeutic approach to pancreatic cancer Protein and alkaloids recover from lupine debittering leaching waters Study of the composition and elemental bioaccessibility of the macroalga Asparagopsis taxiformis and isolation of biomass fractions thereof enriched in elements of critical importance Optimization and validation of methods for the determination of proximal and lipid composition in macroalgal matrices. Characterization of several seaweeds of interest selected from the main taxonomic groups (green, brown, and red algae) CO2 reduction with formate dehydrogenase mimetic compounds Development of PRIDEs – PolymeRIc Deep Eutectic solvents - for CO2 capture
Master Thesis in 2018/2019 Multistate/Multiresponsive Host-Guest Complexes Aplicação de aminoguanidinas ciclicas em organocatálise
Functionalization of PLGA polymeric macromolecules for transformation into nanoparticles for eventual pharmaceutical application.
Molecular properties of volatile sensing materials
Identification of toxic compounds in forensic context
Synthesis of sustainable polymers to achieve protein stable white wines
Synthesis and biological activities studies of novel phenylpropanoid sugar derivatives
Síntese de um diterpeno de origem marinha
Exploring the biological role of (aza)indoles as potential new covalent drugs
New Hetero-branched sensitizers for DSSC
SugarPharma - Abordagens de Química Verde para Aumentar a Atividade Antitumoral de Ésteres de Açúcares Naturais, Encontrados em Plantas Medicinais
Síntese do alcalóide cernumidina A e suas aplicações
Exploring azaindoles structural diversity by novel metal-catalyzed approaches
Optimization of derivatization and validation of a HPLC-UV quantification method of Glyphosate and AMPA in water matrixes.
Molecular recognition of tumor-associated glycan antigens and the Siglec-9 immunomodulatory lectin.
Master Thesis in 2017/2018 Luminescent probes for ovarian cancer early detection Novel synthetic routes towards azaindoles: exploring metal-catalysed one-pot approaches
Pharmaceutically Active Nature-Inspired Ionic Fluids: A Promising Bioavailability-Enhancing Development Option for Pharmaceuticals
Fatty acids profiling in Micropterussalmoides by gas-chromatography/mass spectrometry
Development and characterization of nanoagents to treat Rheumatoid Arthritis
In vivo and in vitro studies of an ATP hydrolyzing protein from Streptococcus pneumoniae
Smart mesoporous silica glyconanoparticles for theranostics
Design and Synthesis of Small Protein-Based Scaffolds for Biocatalysis
REACTIVITY AND APPLICABILITY OF AZOLIUM SALTS
Structural and functional studies of a new class of Mycobacterium tuberculosis inhibitors
Novel small molecules to target Alzheimer’s disease
Synthesis of new triarylmethanes (TRAM) as potential autophagy agents
A rational approach towards novel modulators of necroptosis
Synthesis of tailored poly(3-hexylthiophene) nanoparticles containing thiophene‑S,S‑dioxide for electrochromic applications
Synthesis of methyl-mannoligosaccharide precursors
Síntese do alcalóide cernumidina A e suas aplicações
Novel water-soluble emitters for imaging and sensing applications
Síntese de um metabolito de origem marinha
Master Thesis in 2016/2017 Fotoindução quiral em líquidos iónicos Sustainable synthesis of heterocyclic compounds: exploring cascade reactions on a soluble polymer support Molecular recognition of MUC1 Tumor-associated antigens by lectins & antibodies
Development of in-cell NMR methodologies
Development of novel small molecules to Efficiently Inhibit Neural Tumorigenesis
Caracterização do perfil volátil da bebida de café espresso (Ristreto, Espresso ou Lungo) para os blends usados no sistema de extração Mocoffee.
Development of novel anti-cancer agents
Volatile organic compounds profile variation of olive oils blends under storage
Implementação e Validação de um método de ensaio para análise de metais em águas superficiais e águas de consumo humano por ICP/MS e/ou ICP óptico usando amostradores passivos
Synthesis of Smart Biocompatible Nanoparticles for Bio- Applications.
Untangling interactions of Bio-inspired Cresyl Violet Derivatives with essential and toxic metal ions. Studies and applications in biological samples.
Synthesis of new macromolecules with potential biological activity based on glucose
Investigation of novel sulfonylation methods
New synthetic routes for the valorization of easily accessible bio-renewable resources
Development of new functional cross-linked biopolymers
Caracterização do perfil de compostos orgânicos voláteis no ar interior do departamento de Química
Implementação e Validação de um método de ensaio para análise de compostos orgânicos em águas superficiais por GC/MS e LC-MS/MS usando amostradores passivos.
Development of new photoluminescent materials based on perovskite-like nanocrystals
Diarylethene Linkers for Supramolecular Polymers
Conversion of chitin into biologically valuable chitooligosaccharides: synthetic studies towards NAG-NAM oligosaccharides
From sugar based bio renewable resources to new chemical building blocks and bioactive molecules
Chirality, flavour and anti-oxidant behavior in selected foods
Synthesis of new macromolecules with potential biological activity based on manose
Aplicação de aminoguanidinas ciclicas em organocatálise
Master Thesis in 2015/2016 Reaction-Separation process integration in the production of cyclic carbonates from CO2 Selenium-containing purines and poliphenols: antioxidant and anti-cancer properties Synthesis and characterization of photoactive ionic liquids Coumarin-based organic chromophores: a polyfunctional substrate for diverse applications - fluorescent polymers and drug delivery carriors
Organocatalyzed Domino Reactions With α,ß-Unsaturated Carbonyl Compounds: A Theoretical Study
Development of cellulosic polymer ionic liquids as self-healing soft materials
Otimização e validação dos métodos de análise de Azoto Amoniacal, Nítrico e Kjeldahl em lamas e solos
Untangling interactions of Bio-inspired Cresyl Violet Derivatives with essential and toxic metal ions. Studies and applications in biological samples.
Aggregation Induced Emission from Ionic Liquid based Au(I) complexes and applications
Procura de novos antibióticos. Síntese, caracterização e deteminação da actividade biológica.
Isolation and identification of bioactive secondary metabolites from Streptomyces sp. strains obtained from ocean sediments from the Madeira Archipelago
Development of multifunctional composite aerosols for lung cancer therapy
Desenvolvimento e Validação de um método de ensaio para análise de haloacetonitrilos por cromatografia gasosa associada à espectrometria de massa
Optimization of the modulation parameters in GCxGC analysis
Wine volatile profiles development after contact with four different wood botanical varieties
Síntese do alcalóide cernumidina A e suas aplicações
Development of novel dual-catalyst ionic liquids and salts for asymmetric catalysis
Flavylium-Functionalized Carbon Quantum Dots
A Metabolomic/computational approach for marine natural products drug discovery
Caracterização do perfil de compostos orgânicos voláteis em seres humanos
Targeting p53-MDM2/X interactions: Design, synthesis and biological evaluation of novel small molecules
Master Thesis in 2014/2015 Caracterização de biomarcadores geoquímicos orgânicos em solos e águas subterrâneas Using N-Heterocyclic carbene (NHC) as a catalyst for methylene transfer reactions: Focus on amination reactions. Biomimetic oxidation of xenobiotics by Laccases: generation of quinoid electrophilic intermediates Quantification of Nevirapine protein adducts in HIV patients: development and validation of mass spectrometric –based method Synthesis and Structural characterization of covalent DNA adducts formed with the vasopressin antagonist Tolvaptan Synthesis of photoactive dendrimers for green photovoltaics Targeting p53-MDM2 interaction: Design, synthesis and biological evaluation of novel MDM2 inhibitors Novel synthetic strategies towards azaindoles - promising COX-2 inhibitors Exploring the delivery mechanism to tumor cells based on reversible iminoboronates New synthetic methodology for the asymmetric synthesis of carbocycles and biological evaluation Synthesis of methyl-mannoligosaccharide precursors Radioiodinated compounds for DNA-targeted radiotherapy Desenvolvimento de eléctrodos baseado em nanopartículas de WO3 para aplicação como biossensores
Use of amino acid racemization for forensic biological evidence dating Master Thesis in 2013/14 Studies Towards Modified Chitoologosaccharides: A New Aproach to NAF-MAN Moiety Síntese de muropéptidos bacterianos para estudos de interacção com a vancomicina Racionalização do mecanismo de adição de composto carbonílicos a vinil-mono e di-sulfonas, catalisado por aminas Polímeros electrocrómicos confinados em sistemas mesoporosos Electrochemical Supercapacitors of Condutive Polymers and Their Composites Application of NMR RDC´s, Relaxation and Self-Diffusion for the Study of Dynamic Processes of Small Molecules in Solution
Selectores quirais aplicados à separação cromatoráfica