Arcau, J, Andermark V, Aguiló E, Gandioso A, Moro A, Cetina M, Lima JC, Rissanen K, Ottb I, Rodríguez L.
2014.
Luminescent alkynyl-gold(I) coumarin derivatives and their biological activity. Dalton Transactions. 43:4426-4436.
AbstractLuminescent alkynyl-gold(I) coumarin derivatives and their biological activity
The synthesis and characterization of three propynyloxycoumarins are reported in this work together with the formation of three different series of gold(I) organometallic complexes. Neutral complexes are constituted by water soluble phosphines (PTA and DAPTA) which confer water solubility to them. The X-ray crystal structure of 7-(prop-2-in-1-yloxy)-1-benzopyran-2-one and its corresponding dialkynyl complex is also shown and the formation of rectangular dimers for the gold derivative in the solid state can be observed. A detailed analysis of the absorption and emission spectra of both ligands and complexes allows us to attribute the luminescent behaviour to the coumarin organic ligand. Moreover, the presence of the gold(I) metal atom seems to be responsible for an increase of coumarin phosphorescence emission. The biological activity of the complexes showed that the anionic complexes triggered strong cytotoxic effects in two different cell lines whereas the neutral gold alkynyl complexes led to lower effects against tumor cell growth. Thioredoxin reductase (TrxR) inhibition was very strong in the case of the neutral complexes (IC50 values below 0.1 μM) but moderate for the anionic complexes (IC50 values above 0.8 μM).
Velasco, LF, Lima JC, Ania C.
2014.
Visible-Light Photochemical Activity of Nanoporous Carbons under Monochromatic Light. Angewandte Chemie International Edition. 53:1-4.
AbstractBy using monochromatic light the ability of semiconductor-free nanoporous carbons to convert the low-energy photons from the visible spectrum into chemical reactions (i.e. phenol photooxidation) is demonstrated. Data shows that the onset wavelength of the photochemical activity can be tuned by surface functionalization, with enhanced visible-light conversion upon introducing N-containing groups.
Moro, AJ, Pana A-M, Cseh L, Costisor O, Parola J, Cunha-Silva L, Puttreddy R, Rissanen K, Pina F.
2014.
Chemistry and Photochemistry of 2,6-Bis(2-hydroxybenzilidene)cyclohexanone. An Example of a Compound Following the Anthocyanins Network of Chemical Reactions. Journal of Physical Chemistry A. 118:6208-6215., Number 32
Abstractn/a
Marrucho, IM, Branco LC, Rebelo LPN.
2014.
Ionic Liquids in Pharmaceutical Applications. Annual Review of Chemical and Biomolecular Engineering, Vol 5. 5(
Prausnitz, J. M., Doherty, M. F., Segalman, R. A., Eds.).:527-546.
Abstractn/a