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Bassani, DM, Cucinotta F, Bohne C, Basilio N, Lemon C, Allain C, Sundstrom V, Campagna S, Rohacova J, Ketteler Y, Ryan STJ, Vos J, de Silva AP, Slota M.  2015.  Light activated molecular machines and logic gates: general discussion, 2015. Faraday Discussions. 185:399-411. Abstract
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Pinheiro, AV, Baptista P, Lima JC.  2008.  Light activation of transcription: photocaging of nucleotides for control over RNA polymerization. Nucleic Acids Research. 36, Number 14 Abstract
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Maestri, M, Pina F, Roque A, Passaniti P.  2000.  Light and pH switching between the various forms of the 4 '-methylflavylium cation. Journal of Photochemistry and Photobiology a-Chemistry. 137:21-28., Number 1 Abstract
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Laia, CAT, Brown W, Almgren M, Costa SMB.  2000.  Light scattering study of water-in-oil AOT microemulsions with poly(oxy)ethylene. Langmuir. 16:465-470., Number 2 Abstract
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Ferrer, M, Rodriguez L, Rossell O, Pina F, Lima JC, Bardia MF, Solans X.  2003.  Linear ditopic acetylide gold or mercury complexes: synthesis and photophysic studies X-ray crystal structure of PPh4[Au(C CC5H4N)(2)]. Journal of Organometallic Chemistry. 678:82-89., Number 1-2 Abstract
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Monteiro, B, Gago S, Balula SS, Valente AA, Goncalves IS, Pillinger M.  2009.  Liquid-phase oxidation catalysed by copper(II) immobilised in a pillared layered double hydroxide. Journal of Molecular Catalysis a-Chemical. 312:23-30., Number 1-2 Abstract
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Pina, F, Lima JC, Lodeiro C, de Melo JS, Diaz P, Albelda MT, Garcia-Espana E.  2002.  Long range electron transfer quenching in polyamine chains bearing a terminal naphthalene unit. Journal of Physical Chemistry a. 106:8207-8212., Number 35 Abstract
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Arcau, J, Andermark V, Aguiló E, Gandioso A, Moro A, Cetina M, Lima JC, Rissanen K, Ottb I, Rodríguez L.  2014.  Luminescent alkynyl-gold(I) coumarin derivatives and their biological activity. Dalton Transactions. 43:4426-4436. Abstract

Luminescent alkynyl-gold(I) coumarin derivatives and their biological activity

The synthesis and characterization of three propynyloxycoumarins are reported in this work together with the formation of three different series of gold(I) organometallic complexes. Neutral complexes are constituted by water soluble phosphines (PTA and DAPTA) which confer water solubility to them. The X-ray crystal structure of 7-(prop-2-in-1-yloxy)-1-benzopyran-2-one and its corresponding dialkynyl complex is also shown and the formation of rectangular dimers for the gold derivative in the solid state can be observed. A detailed analysis of the absorption and emission spectra of both ligands and complexes allows us to attribute the luminescent behaviour to the coumarin organic ligand. Moreover, the presence of the gold(I) metal atom seems to be responsible for an increase of coumarin phosphorescence emission. The biological activity of the complexes showed that the anionic complexes triggered strong cytotoxic effects in two different cell lines whereas the neutral gold alkynyl complexes led to lower effects against tumor cell growth. Thioredoxin reductase (TrxR) inhibition was very strong in the case of the neutral complexes (IC50 values below 0.1 μM) but moderate for the anionic complexes (IC50 values above 0.8 μM).

Lodeiro, C, Pina F.  2009.  Luminescent and chromogenic molecular probes based on polyamines and related compounds. Coordination Chemistry Reviews. 253:1353-1383., Number 9-10 Abstract
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Gavara, R, Llorca J, Lima JC, Rodriguez L.  2013.  A luminescent hydrogel based on a new Au(I) complex. Chemical Communications. 49:72-74., Number 1 Abstract
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Brissos, R, Ramos D, Lima JC, Mihan FY, Borras M, de Lapuente J, Dalla Cort A, Rodriguez L.  2013.  Luminescent zinc salophen derivatives: cytotoxicity assessment and action mechanism studies. New Journal of Chemistry. 37:1046-1055., Number 4 Abstract
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