<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Santos, Marino F. A.</style></author><author><style face="normal" font="default" size="100%">Isabel Correia</style></author><author><style face="normal" font="default" size="100%">Oliveira, Ana R.</style></author><author><style face="normal" font="default" size="100%">Garribba, Eugenio</style></author><author><style face="normal" font="default" size="100%">João Costa Pessoa</style></author><author><style face="normal" font="default" size="100%">Santos-Silva, Teresa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Vanadium Complexes as Prospective Therapeutics: Structural Characterization of a VIV Lysozyme Adduct</style></title><secondary-title><style face="normal" font="default" size="100%">European Journal of Inorganic Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Density functional calculations</style></keyword><keyword><style  face="normal" font="default" size="100%">EPR spectroscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein adducts</style></keyword><keyword><style  face="normal" font="default" size="100%">Vanadium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1002/ejic.201402408</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">WILEY-VCH Verlag</style></publisher><pages><style face="normal" font="default" size="100%">n/a–n/a</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The biological activity of vanadium complexes, namely, as insulin enhancers, is well known. We report a combined X-ray crystallography, electron paramagnetic resonance, and density functional theory study of the interaction of vanadium picolinate complexes with hen egg white lysozyme (HEWL). We show that the VIVO(pic)2 complex covalently binds to the COO– group of the side chain of Asp52 of HEWL. The long VIV=O bond obtained in the X-ray study is explained to be due to reduction of VIV to VIII during exposure of the crystals to the intense X-ray beam.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record></records></xml>