@article {15667,
	title = {Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules},
	journal = {ACS Biomaterials Science \& EngineeringACS Biomaterials Science \& Engineering},
	volume = {6},
	year = {2020},
	note = {<p>doi: 10.1021/acsbiomaterials.9b01936</p>
},
	month = {2020},
	pages = {1090 - 1101},
	publisher = {American Chemical Society},
	abstract = {<p>CO-releasing molecules (CORMs) have been widely studied for their anti-inflammatory, antiapoptotic, and antiproliferative effects. CORM-3 is a water-soluble Ru-based metal carbonyl complex, which metallates serum proteins and readily releases CO in biological media. In this work, we evaluated the anti-inflammatory and wound-healing effects of gold nanoparticles{\textendash}CORM-3 conjugates, AuNPs@PEG@BSA{\textperiodcentered}Ru(CO)x, exploring its use as an efficient CO carrier. Our results suggest that the nanoformulation was capable of inducing a more pronounced cell effect, at the anti-inflammatory level and a faster tissue repair, probably derived from a rapid cell uptake of the nanoformulation that results in the increase of CO inside the cell.CO-releasing molecules (CORMs) have been widely studied for their anti-inflammatory, antiapoptotic, and antiproliferative effects. CORM-3 is a water-soluble Ru-based metal carbonyl complex, which metallates serum proteins and readily releases CO in biological media. In this work, we evaluated the anti-inflammatory and wound-healing effects of gold nanoparticles{\textendash}CORM-3 conjugates, AuNPs@PEG@BSA{\textperiodcentered}Ru(CO)x, exploring its use as an efficient CO carrier. Our results suggest that the nanoformulation was capable of inducing a more pronounced cell effect, at the anti-inflammatory level and a faster tissue repair, probably derived from a rapid cell uptake of the nanoformulation that results in the increase of CO inside the cell.</p>
},
	url = {https://doi.org/10.1021/acsbiomaterials.9b01936},
	author = {Alexandra R. Fernandes and Mendon{\c c}a-Martins, In{\^e}s and Santos, Marino F. A. and Lu{\'\i}s R. Raposo and Rita Mendes and Marques, Joana and Rom{\~a}o, Carlos C. and Rom{\~a}o, Maria Jo{\~a}o and Santos-Silva, Teresa and Pedro V. Baptista}
}
