@article {EJOC:EJOC201701500,
	title = {Synthesis, cytotoxicity evaluation in human cell lines and in vitro DNA interaction of a hetero arylidene-9(10H)-anthrone},
	journal = {European Journal of Organic Chemistry},
	year = {2018},
	note = {<p>n/a</p>
},
	pages = {n/a{\textendash}n/a},
	abstract = {<p>A new and never yet reported hetero arylidene-9(10H)-anthrone structure (4) was unexpectedly isolated on reaction of 1,2-dimethyl-3-ethylimidazolium iodide (2) and 9-anthracenecarboxaldehyde (3) under basic conditions. Its structure was unequivocally attributed by X-ray crystallography. No cytotoxicity in human healthy fibroblasts and in two different cancer cell lines was observed indicating its applicability in biological systems. Compound 4 interacts with CT-DNA by intercalation between the adjacent base pairs of DNA with a high binding affinity (Kb = 2.0({\textpm} 0.20) x 105 M-1) which is 10x higher than that described for doxorubicin (Kb = 3.2 ({\textpm}0.23) {\texttimes} 104 M-1). Furthermore, compound 4 quenches the fluorescence emission of GelRed-CT-DNA system with a quenching constant (KSV) of 3.3({\textpm}0.3) x 103 M-1 calculated by the Stern-Volmer equation.</p>
},
	keywords = {anthracenecarboxaldehyde, arylidene anthrone, Decarbonylation, DNA intercalation, Imidazolium salt},
	issn = {1099-0690},
	doi = {10.1002/ejoc.201701500},
	url = {http://dx.doi.org/10.1002/ejoc.201701500},
	author = {Branco, Paula S. and Peixoto, Daniela and Figueiredo, Margarida and Malta, Gabriela and Catarina Roma-Rodrigues and Batista, Pedro Viana and Alexandra R. Fernandes and Barroso, S{\'o}nia and Carvalho, Ana Luisa and Afonso, Carlos A. M. and Ferreira, Lu{\'\i}sa Maria}
}
