@article {Schmolka2013,
	title = {Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδT cell subsets.},
	journal = {Nature immunology},
	volume = {14},
	number = {10},
	year = {2013},
	note = {<p>n/a</p>
},
	pages = {1093{\textendash}1100},
	publisher = {Nature Publishing Group},
	abstract = {<p>Two distinct subsets of γδ T cells that produce interleukin 17 (IL-17) (CD27(-) γδ T cells) or interferon-γ (IFN-γ) (CD27(+) γδ T cells) develop in the mouse thymus, but the molecular determinants of their functional potential in the periphery remain unknown. Here we conducted a genome-wide characterization of the methylation patterns of histone H3, along with analysis of mRNA encoding transcription factors, to identify the regulatory networks of peripheral IFN-γ-producing or IL-17-producing γδ T cell subsets in vivo. We found that CD27(+) γδ T cells were committed to the expression of Ifng but not Il17, whereas CD27(-) γδ T cells displayed permissive chromatin configurations at loci encoding both cytokines and their regulatory transcription factors and differentiated into cells that produced both IL-17 and IFN-γ in a tumor microenvironment.</p>
},
	keywords = {Animals, Antigen, Cell Differentiation, Cell Differentiation: genetics, Cytokines, Cytokines: genetics, Cytokines: metabolism, Epigenesis, Female, gamma-delta, gamma-delta: genetics, gamma-delta: metabolism, gd T, Gene Expression Profiling, Gene Expression Regulation, Genetic, Genome-Wide Association Study, Histones, Histones: metabolism, Knockout, Methylation, Mice, Receptors, T-Cell, T-Lymphocyte Subsets, T-Lymphocyte Subsets: cytology, T-Lymphocyte Subsets: immunology, T-Lymphocyte Subsets: metabolism, Th1 Cells, Th1 Cells: immunology, Th1 Cells: metabolism, Th17 Cells, Th17 Cells: immunology, Th17 Cells: metabolism, Transcriptome},
	isbn = {3519145383},
	issn = {1529-2916},
	doi = {10.1038/ni.2702},
	url = {https://doi.org/10.1038/ni.2702},
	author = {Schmolka, Nina and Serre, Karine and Ana Rita Grosso and Rei, Margarida and Pennington, Daniel J and Gomes, Anita Q and Silva-santos, Bruno}
}
