<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sílvia Rebocho</style></author><author><style face="normal" font="default" size="100%">Cordas, Cristina M.</style></author><author><style face="normal" font="default" size="100%">Raquel Viveiros</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development of a ferrocenyl-based MIP in supercritical carbon dioxide: Towards an electrochemical sensor for bisphenol A</style></title><secondary-title><style face="normal" font="default" size="100%">The Journal of Supercritical Fluids</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BPA</style></keyword><keyword><style  face="normal" font="default" size="100%">Electrochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Ferrocenylmethyl methacrylate</style></keyword><keyword><style  face="normal" font="default" size="100%">Green solvent</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular imprinting</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0896844617303418</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">135</style></volume><pages><style face="normal" font="default" size="100%">98 - 104</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">n/a</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gonçalo Marcelo</style></author><author><style face="normal" font="default" size="100%">Inês C. Ferreira</style></author><author><style face="normal" font="default" size="100%">Raquel Viveiros</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development of itaconic acid-based molecular imprinted polymers using supercritical fluid technology for pH-triggered drug delivery</style></title><secondary-title><style face="normal" font="default" size="100%">International Journal of Pharmaceutics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Crosslinked polymer</style></keyword><keyword><style  face="normal" font="default" size="100%">Metronidazole</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular imprinting</style></keyword><keyword><style  face="normal" font="default" size="100%">pH-responsive</style></keyword><keyword><style  face="normal" font="default" size="100%">Supercritical carbon dioxide</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S037851731830156X</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">542</style></volume><pages><style face="normal" font="default" size="100%">125 - 131</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">n/a</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Viveiros, R.</style></author><author><style face="normal" font="default" size="100%">K. Karim</style></author><author><style face="normal" font="default" size="100%">S.A. Piletsky</style></author><author><style face="normal" font="default" size="100%">Heggie, W.</style></author><author><style face="normal" font="default" size="100%">T. Casimiro</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development of a molecularly imprinted polymer for a pharmaceutical impurity in supercritical CO2: Rational design using computational approach</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Cleaner Production</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Affinity polymers</style></keyword><keyword><style  face="normal" font="default" size="100%">Computational design</style></keyword><keyword><style  face="normal" font="default" size="100%">Green chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular imprinting</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular modelling</style></keyword><keyword><style  face="normal" font="default" size="100%">Supercritical carbon dioxide</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0959652617320152</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">168</style></volume><pages><style face="normal" font="default" size="100%">1025 - 1031</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">n/a</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raquel Viveiros</style></author><author><style face="normal" font="default" size="100%">Maria Inês Lopes</style></author><author><style face="normal" font="default" size="100%">William Heggie</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Green approach on the development of lock-and-key polymers for API purification</style></title><secondary-title><style face="normal" font="default" size="100%">Chemical Engineering Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Affinity purification</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotoxin removal</style></keyword><keyword><style  face="normal" font="default" size="100%">Green chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular imprinted polymer</style></keyword><keyword><style  face="normal" font="default" size="100%">Supercritical carbon dioxide</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S1385894716312761</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">308</style></volume><pages><style face="normal" font="default" size="100%">229 - 239</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">n/a</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raquel Viveiros</style></author><author><style face="normal" font="default" size="100%">Francisco M. Dias</style></author><author><style face="normal" font="default" size="100%">Maia, Luisa B.</style></author><author><style face="normal" font="default" size="100%">William Heggie</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Green strategy to produce large core–shell affinity beads for gravity-driven API purification processes</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Industrial and Engineering Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">3-(Trimethoxysilyl) propyl methacrylate</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotoxin removal</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasma technology functionalization</style></keyword><keyword><style  face="normal" font="default" size="100%">Supercritical carbon dioxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Surface imprinting technique</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S1226086X17302897</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">54</style></volume><pages><style face="normal" font="default" size="100%">341 - 349</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">n/a</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Teresa Esteves</style></author><author><style face="normal" font="default" size="100%">Raquel Viveiros</style></author><author><style face="normal" font="default" size="100%">João Bandarra</style></author><author><style face="normal" font="default" size="100%">William Heggie</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author><author><style face="normal" font="default" size="100%">Ferreira, Frederico Castelo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Molecularly imprinted polymer strategies for removal of a genotoxic impurity, 4-dimethylaminopyridine, from an active pharmaceutical ingredient post-reaction stream</style></title><secondary-title><style face="normal" font="default" size="100%">Separation and Purification Technology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">4-Dimethylaminopyridine</style></keyword><keyword><style  face="normal" font="default" size="100%">Active pharmaceutical ingredient purification</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotoxic impurity</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecularly imprinted polymer</style></keyword><keyword><style  face="normal" font="default" size="100%">Mometasone furoate</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S138358661630048X</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">163</style></volume><pages><style face="normal" font="default" size="100%">206 - 214</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">n/a</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ferreira, Joana P.</style></author><author><style face="normal" font="default" size="100%">Raquel Viveiros</style></author><author><style face="normal" font="default" size="100%">Lourenco, Anita</style></author><author><style face="normal" font="default" size="100%">Mara Soares da Silva</style></author><author><style face="normal" font="default" size="100%">Rosatella, Andreia</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author><author><style face="normal" font="default" size="100%">Afonso, Carlos A. M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Integrated desulfurization of diesel by combination of metal-free oxidation and product removal by molecularly imprinted polymers</style></title><secondary-title><style face="normal" font="default" size="100%">RSC Adv.</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2014</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1039/C4RA11666F</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">The Royal Society of Chemistry</style></publisher><volume><style face="normal" font="default" size="100%">4</style></volume><pages><style face="normal" font="default" size="100%">54948-54952</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The production of ultra-low-sulfur diesel is an important worldwide demand. In this work a novel integrated method for desulfurization of diesel is proposed based on the combination of Bronsted acid catalyzed oxidation and the selective removal of the oxidized products using a molecularly imprinted polymer (MIP) produced in supercritical carbon dioxide (scCO2). The biphasic oxidation reaction of dibenzothiophene sulfone (DBT){,} as model substrate{,} and H2O2 as oxidant{,} was optimized by testing different acid catalysts{,} and also different phase transfer catalysts (PTC){,} including two different ionic liquids (ILs) trihexyl(tetradecyl)phosphoniumchloride [P6{,}6{,}6{,}14]Cl and Aliquat[registered sign]. The products of the efficient oxidation of DBT{,} dibenzothiophene sulfoxide (DBTSO) and dibenzothiophene sulfone (DBTSO2){,} were then selectively removed from real diesel using the MIP.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">André N.C. Martins</style></author><author><style face="normal" font="default" size="100%">Svilen P. Simeonov</style></author><author><style face="normal" font="default" size="100%">Luís M.T. Frija</style></author><author><style face="normal" font="default" size="100%">Raquel Viveiros</style></author><author><style face="normal" font="default" size="100%">Lourenço, Anita</style></author><author><style face="normal" font="default" size="100%">Mara Soares da Silva</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author><author><style face="normal" font="default" size="100%">Afonso, Carlos A. M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Isolation, analytical quantification and seasonal variation of labdanolic acid from the Portuguese-grown Cistus ladaniferus</style></title><secondary-title><style face="normal" font="default" size="100%">Industrial Crops and Products</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Benzylation reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Labdanolic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular imprinted polymers</style></keyword><keyword><style  face="normal" font="default" size="100%">Non-imprinted polymers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0926669014003458</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">60</style></volume><pages><style face="normal" font="default" size="100%">226 - 232</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">n/a</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lourenço, Anita</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author><author><style face="normal" font="default" size="100%">Vasco D.B. Bonifácio</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Reborn water-soluble CdTe quantum dots</style></title><secondary-title><style face="normal" font="default" size="100%">Talanta</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bioimaging</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0039914014002033</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">125</style></volume><pages><style face="normal" font="default" size="100%">319 - 321</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Abstract Recovery of fully aggregated water-soluble CdTe quantum dots was achieved by simple treatment with a strong base. A deprotonation-triggered disaggregation is postulated to be the main mechanism involved in the quantum dots “reborn” process.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lourenco, A.</style></author><author><style face="normal" font="default" size="100%">Viveiros, R.</style></author><author><style face="normal" font="default" size="100%">Mouro, A.</style></author><author><style face="normal" font="default" size="100%">J. C. Lima</style></author><author><style face="normal" font="default" size="100%">Bonifacio, V. D. B.</style></author><author><style face="normal" font="default" size="100%">T. Casimiro</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Supercritical CO2-assisted synthesis of an ultrasensitive amphibious quantum dot-molecularly imprinted sensor</style></title><secondary-title><style face="normal" font="default" size="100%">RSC Adv.</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2014</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1039/C4RA10179K</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">The Royal Society of Chemistry</style></publisher><volume><style face="normal" font="default" size="100%">4</style></volume><pages><style face="normal" font="default" size="100%">63338-63341</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Molecularly imprinted polymers are simple and robust materials for the selective binding of analytes with affinities and selectivities similar to biological probes. A green supercritical CO2-assisted molecular imprinting protocol enabled the production of smart sensory particles{,} incorporating quantum dots{,} with molecular recognition to bisphenol A at very low concentrations (4 nM). The protocol uses amphibious vinyl-coated quantum dots and enables the design of sensors for a wide range of molecules through a simple{,} low cost and clean technology.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mara Soares da Silva</style></author><author><style face="normal" font="default" size="100%">Raquel Viveiros</style></author><author><style face="normal" font="default" size="100%">Mónica B. Coelho</style></author><author><style face="normal" font="default" size="100%">Aguiar-Ricardo, Ana</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Supercritical CO2-assisted preparation of a \{PMMA\} composite membrane for bisphenol A recognition in aqueous environment</style></title><secondary-title><style face="normal" font="default" size="100%">Chemical Engineering Science</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adsorption</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0009250911006488</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">68</style></volume><pages><style face="normal" font="default" size="100%">94 - 100</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;This work reports a novel strategy to prepare affinity composite membranes using supercritical fluid technology. By blending molecularly imprinted polymeric particles with PMMA, a porous hybrid structure with affinity to the template molecule, bisphenol A, was prepared using a supercritical carbon dioxide (scCO2)-assisted method. Membranes were characterized in terms of morphology, mechanical performance and transport properties. The ability of the polymers and hybrid membranes to adsorb bisphenol A was tested in aqueous solutions and fitted to a linearized Langmuir equation, showing that adsorption takes place at homogeneous affinity binding sites within the imprinted surface. Filtration experiments showed that the imprinted hybrid membrane was able to adsorb higher amounts of template even in non-equilibrium dynamic binding conditions. The hybridization of the \{PMMA\} membrane herein reported conveys two important improvements over neat \{PMMA\} membrane: it introduced molecular affinity towards the template molecule and significantly increased the permeability of the porous structures, which are key parameters in processes that involve membranes. This technique could expand the applications of polymeric beads powders and enhance the efficiency of the membrane's transport properties. Our work presents a new method to confer affinity to a porous structure by immobilization of imprinted polymers, combining polymer synthesis and membrane formation using supercritical fluid technology.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mara Soares da Silva</style></author><author><style face="normal" font="default" size="100%">Raquel Viveiros</style></author><author><style face="normal" font="default" size="100%">Aguiar-Ricardo, Ana</style></author><author><style face="normal" font="default" size="100%">Bonifacio, Vasco D. B.</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Supercritical fluid technology as a new strategy for the development of semi-covalent molecularly imprinted materials</style></title><secondary-title><style face="normal" font="default" size="100%">RSC Adv.</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2012</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1039/C2RA20426F</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">The Royal Society of Chemistry</style></publisher><volume><style face="normal" font="default" size="100%">2</style></volume><pages><style face="normal" font="default" size="100%">5075-5079</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Molecularly imprinted polymeric particles with molecular recognition towards Bisphenol A (BPA) were synthesized for the first time using the semi-covalent imprinting approach in supercritical carbon dioxide (scCO2). The material{'}s affinity to BPA was achieved by co-polymerizing ethylene glycol dimethacrylate (EGDMA) with a template-containing monomer{,} Bisphenol A dimethacrylate (BPADM) in scCO2. Bisphenol A is then cleaved from the polymeric matrix by hydrolysis with tetrabutylammonium hydroxide (n-Bu4OH) also in a supercritical environment{,} taking advantage of the high diffusivity of scCO2. The selectivity of the molecular imprinted polymer (MIP) was assessed by evaluating its capability to bind BPA in comparison with progesterone and [small alpha]-ethinylestradiol. In addition{,} the cross-linked particles were used to prepare a PMMA-based hybrid imprinted membrane by a scCO2-assisted phase inversion method. Results show that the incorporation of MIP particles was able to confer molecular affinity to BPA to the membrane and that at dynamic conditions of filtration{,} this imprinted porous structure was able to adsorb a higher amount of BPA than the corresponding non-imprinted hybrid membrane. Our work represents a valuable greener alternative to conventional methods{,} for the synthesis of affinity materials which are able to maintain molecular recognition properties in water.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mara Soares da Silva</style></author><author><style face="normal" font="default" size="100%">Raquel Viveiros</style></author><author><style face="normal" font="default" size="100%">Patrícia I. Morgado</style></author><author><style face="normal" font="default" size="100%">Aguiar-Ricardo, Ana</style></author><author><style face="normal" font="default" size="100%">Correia, Ilídio J</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development of 2-(dimethylamino)ethyl methacrylate-based molecular recognition devices for controlled drug delivery using supercritical fluid technology</style></title><secondary-title><style face="normal" font="default" size="100%">International Journal of Pharmaceutics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">\{DMAEMA\}</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0378517311005357</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">416</style></volume><pages><style face="normal" font="default" size="100%">61 - 68</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;This work reports the development of a novel potential body-friendly oral drug delivery system, which consists of a biocompatible molecularly imprinted polymer (MIP), with pH sensitive character and low cross-linking degree (20.2&amp;#xa0;wt%), synthesized and processed in supercritical carbon dioxide. The \{MIP\} is synthesized using 2-(dimethylamino)ethyl methacrylate (DMAEMA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker, and ibuprofen as molecular recognition template. The imprinted matrix was able to show a higher affinity towards ibuprofen than its corresponding non-imprinted polymer (NIP) meaning that the molecular imprinting in scCO2 was efficient even using a low crosslinking degree. \{MIP\} showed a significant molecular recognition towards the template, presenting higher drug uptake ability in the supercritical impregnation step, loading 33.1&amp;#xa0;wt% of ibuprofen compared to only 10.2&amp;#xa0;wt% for the \{NIP\} polymer. In vitro drug release experiments, simulating an oral administration, showed different release profiles at pH 2.2 and pH 7.4. Zeta potential measurements were performed to both \{MIP\} and \{NIP\} showing that the imprinting process has a significant influence on the charge of the polymeric particles. Cytotoxicity assays performed with human colorectal carcinoma-derived Caco-2 cells demonstrated that the polymers are biocompatible and could be potentially used in drug delivery applications.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mara Soares da Silva</style></author><author><style face="normal" font="default" size="100%">Franklin L. Nobrega</style></author><author><style face="normal" font="default" size="100%">Aguiar-Ricardo, Ana</style></author><author><style face="normal" font="default" size="100%">Cabrita, Eurico J.</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development of molecularly imprinted co-polymeric devices for controlled delivery of flufenamic acid using supercritical fluid technology</style></title><secondary-title><style face="normal" font="default" size="100%">The Journal of Supercritical Fluids</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Crosslinking</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0896844611001872</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">58</style></volume><pages><style face="normal" font="default" size="100%">150 - 157</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;This work reports the development of a novel class of affinity co-polymeric materials using supercritical fluid technology. Polymeric materials with molecular recognition to flufenamic acid, were first synthesized in supercritical carbon dioxide (scCO2) using the drug as template. Molecularly imprinted co-polymers of methacrylic acid (MAA) or N-isopropyl acrylamide (NIPAAm) crosslinked with ethylene glycol dimethacrylate (EGDMA) were synthesized using different crosslinking degrees and template:monomer ratios, at 65&amp;#xa0;°C and 21&amp;#xa0;MPa. High-pressure \{NMR\} experiments confirmed that the nature of the interactions between the drug and the functional monomers during the polymerization step are mainly hydrogen bonds. scCO2-assisted impregnation revealed that the imprinted matrices were able to uptake higher amounts of flufenamic acid. This effect was particularly evidenced in the more crosslinked matrices, with P(MAA–EGDMA) imprinted copolymers binding up to 101.5&amp;#xa0;mg drug/g polymer against only 50.5&amp;#xa0;mg/g in the non-imprinted copolymer. In vitro drug delivery experiments showed that imprinted co-polymers release the drug in a more sustained way than the corresponding non-imprinted matrices. Overall it was shown that supercritical fluid technology is a viable approach for the development of self-assembly molecular recognition polymers with potential application in controlled drug delivery systems.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mara Soares da Silva</style></author><author><style face="normal" font="default" size="100%">Eva R. Vão</style></author><author><style face="normal" font="default" size="100%">Temtem, Márcio</style></author><author><style face="normal" font="default" size="100%">Luís Mafra</style></author><author><style face="normal" font="default" size="100%">Jorge Caldeira</style></author><author><style face="normal" font="default" size="100%">Aguiar-Ricardo, Ana</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as \{HPLC\} stationary phases</style></title><secondary-title><style face="normal" font="default" size="100%">Biosensors and Bioelectronics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">\{HPLC\}</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2010</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0956566309007015</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">7</style></number><volume><style face="normal" font="default" size="100%">25</style></volume><pages><style face="normal" font="default" size="100%">1742 - 1747</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Molecularly imprinted polymers (MIPs) of poly(ethylene glycol dimethacrylate) and poly(N-isopropylacrylamide-co-ethylene glycol dimethacrylate) were synthesized for the first time in supercritical carbon dioxide (scCO2), using Boc-l-tryptophan as template. Supercritical fluid technology provides a clean and one-step synthetic route for the preparation of affinity polymeric materials with sensing capability for specific molecules. The polymeric materials were tested as stationary \{HPLC\} phases for the enantiomeric separation of l- and d-tryptophan. \{HPLC\} results prove that the synthesized \{MIPs\} are able to recognize the template molecule towards its enantiomer which opens up potential applications in chromatographic chiral separation.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ana Rita C. Duarte</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author><author><style face="normal" font="default" size="100%">Aguiar-Ricardo, Ana</style></author><author><style face="normal" font="default" size="100%">Ana Luísa Simplício</style></author><author><style face="normal" font="default" size="100%">Duarte, Catarina M. M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Supercritical fluid polymerisation and impregnation of molecularly imprinted polymers for drug delivery</style></title><secondary-title><style face="normal" font="default" size="100%">The Journal of Supercritical Fluids</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cross-linking</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2006</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0896844606000362</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">39</style></volume><pages><style face="normal" font="default" size="100%">102 - 106</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems.&lt;/p&gt;
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