Publications

Sort by: [ Author (Asc)] Title Type Year
A B C D E F G H I J K [L] M N O P Q R S T U V W X Y Z   [Show ALL]
L
Larguinho, Miguel, Daniela Correia, Mario S. Diniz, and Pedro V. Baptista. "Evidence of one-way flow bioaccumulation of gold nanoparticles across two trophic levels." Journal of Nanoparticle Research 16 (2014). Abstract

n/a

Larguinho, M., J. L. Capelo, and P. V. Baptista. "Fast nucleotide identification through fingerprinting using gold nanoparticle-based surface-assisted laser desorption/ionisation." Talanta 105 (2013): 417-21. AbstractWebsite

n/a

Larguinho, Miguel, José L. Capelo, and Pedro V. Baptista. "Fast Nucleotide identification using gold nanoparticle-based surface assisted laser desorption/ionisation." Talanta 105 (2013): 417-421.
Larguinho, Miguel, Sofia Santos, Joao Almeida, and Pedro V. Baptista. "DNA adduct identification using gold-aptamer nanoprobes." Iet Nanobiotechnology 9 (2015): 95-101. Abstract

n/a

Larguinho, Miguel, Rafaela Canto, Milton Cordeiro, Pedro Pedrosa, Andreia Fortuna, Raquel Vinhas, and Pedro V. Baptista. "Gold nanoprobe-based non-crosslinking hybridization for molecular diagnostics." Expert Review of Molecular Diagnostics 15 (2015): 1355-1368. Abstract

n/a

Larguinho, Miguel, Pedro M. Costa, Gonçalo Sousa, Maria H. Costa, Mário S. Diniz, and Pedro V. Baptista. "Histopathological findings on Carassius auratus hepatopancreas upon exposure to acrylamide: correlation with genotoxicity and metabolic alterations." Journal of Applied Toxicology 34 (2014).
Larguinho, Miguel, Hugo M. Santos, Gonçalo Doria, H. Scholz, Pedro V. Baptista, and José L. Capelo. "Development of a fast and efficient ultrasonic-based strategy for DNA fragmentation." J. Talanta 81 (2010): 881-886.
Larguinho, Miguel, Ana Cordeiro, Mario S. Diniz, Pedro M. Costa, and Pedro V. Baptista. "Metabolic and histopathological alterations in the marine bivalve Mytilus galloprovincialis induced by chronic exposure to acrylamide." Environmental Research 135 (2014): 55-62. Abstract

n/a

Larguinho, Miguel, Sara Figueiredo, Ana Cordeiro, Fábio Ferreira Carlos, Milton Cordeiro, Pedro Pedrosa, and Pedro Viana Baptista. "Nanoparticles for Diagnostics and Imaging." In Frontiers in Nanomedicine, edited by Maria Luisa Bondì Bondì, Chiara Botto and Erika Amore, 3-46. Bentham Science, 2015. Abstractsample.pdf

Nanoparticles possess unique optical and physic-chemical properties that may potentiate applications in biomedicine, in particular in diagnostics, therapy and imaging. Advances on biomolecular diagnostics strategies have greatly focused on single molecule detection and characterization of DNA, RNA or proteins through improved nanoparticle-based platforms. Nanoparticles improve analytical capability when compared to traditional techniques with high resolution and medium-high throughput. Also, particular interest has been directed at SNP detection, gene expression profiles and biomarker characterization through colorimetric, spectrometric or electrochemical strategies.
Molecular imaging has also benefited from the introduction of nanoparticles in standard techniques towards non-invasive imaging procedures that can be used to highlight regions of interest, allowing the characterization of biological processes at the cellular and/or molecular level. Several imaging modalities are associated with low sensitivity, an issue that can be tackled by the use of probes, e.g. contrast agents for X-ray and magnetic resonance imaging, radiolabelled molecules for nuclear medicine. Furthermore, nanoparticles can be used as vehicles that deliver specifically these contrast agents, leading to overcome the limitations of conventional modalities.
This chapter will discuss the use of nanoparticles in biomolecular recognition and imaging applications, focusing those already being translated into clinical settings. Current knowledge will be addressed as well as its evolution towards the future of nanoparticle-based biomedical applications.

Larguinho, Miguel, and Pedro V. Baptista. "Gold and silver nanoparticles for clinical diagnostics - from genomics to proteomics." J. Proteomics 75 (2012): 2811-2823.
Lenis-Rojas, O. A., A. R. Fernandes, C. Roma-Rodrigues, P. V. Baptista, F. Marques, D. Perez-Fernandez, J. Guerra-Varela, L. Sanchez, D. Vazquez-Garcia, M. Lopez Torres, A. Fernandez, and J. J. Fernandez. "Heteroleptic mononuclear compounds of ruthenium(II): synthesis, structural analyses, in vivo antitumor activity and in vivo toxicity on zebrafish embryost." Dalton Transactions 45 (2016): 19127-19140. Abstract

n/a

Luis, Daniel V., Joana Silva, Ana Isabel Tomaz, Rodrigo F. M. de Almeida, Miguel Larguinho, Pedro V. Baptista, Luisa M. D. R. S. Martins, Telma F. S. Silva, Pedro M. Borralho, Cecilia M. P. Rodrigues, Antonio S. Rodrigues, Armando J. L. Pombeiro, and Alexandra R. Fernandes. "Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies." Journal of Biological Inorganic Chemistry 19 (2014): 787-803. Abstract

n/a

Luisa Corvo, M., Ana Soraia Mendo, Sara Figueiredo, Rogerio Gaspar, Miguel Larguinho, Fatima M. C. Guedes da Silva, Pedro Viana Baptista, and Alexandra R. Fernandes. "Liposomes as Delivery System of a Sn(IV) Complex for Cancer Therapy." Pharmaceutical Research 33 (2016): 1351-1358. Abstract

n/a