Publications

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Daniela, Peixoto, Figueiredo Margarida, Malta Gabriela, Roma‐Rodrigues Catarina, Baptista Pedro V., Fernandes Alexandra R., Barroso Sónia, Carvalho Ana Luísa, Afonso Carlos A. M., Ferreira Luisa M., and Branco Paula S. "Synthesis, Cytotoxicity Evaluation in Human Cell Lines and in Vitro DNA Interaction of a Hetero‐Arylidene‐9(10H)‐Anthrone." European Journal of Organic ChemistryEuropean Journal of Organic Chemistry 2018 (2018): 545-549. AbstractWebsite

A new and never before reported hetero?arylidene?9(10H)?anthrone structure (4) was unexpectedly isolated on reaction of 1,2?dimethyl?3?ethylimidazolium iodide (2) and 9?anthracenecarboxaldehyde (3) under basic conditions. Its structure was unequivocally confirmed by X?ray crystallography. No cytotoxicity in human healthy fibroblasts and in two different cancer cell lines was observed, indicating its applicability in biological systems. Compound 4 interacts with CT?DNA by intercalation between the adjacent base pairs of DNA with a high binding affinity [Kb = 2.0?(±0.20)???105 m?1], which is 10?? higher than that described for doxorubicin [Kb = 3.2?(±0.23)???104 m?1]. Furthermore, compound 4 quenches the fluorescence emission of a GelRed?CT?DNA system with a quenching constant (KSV) of 3.3?(±0.3)???103 m?1 calculated by the Stern?Volmer equation.

Das, Kuheli, Amitabha Datta, Chiara Massera, Catarina Roma-Rodrigues, Mariana Barroso, Pedro V. Baptista, and Alexandra R. Fernandes. "Structural aspects of a trimetallic CuII derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines." Journal of Coordination Chemistry 72 (2019): 920-940. AbstractWebsite

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Doria, G., J. T. Dias, M. Larguinho, E. Pereira, R. Franco, and P. Baptista. AuAg-alloy-nanoprobes for Specific Nucleic Acid Detection In NSTI-Nanotech 2010. Anaheim, CA, 2010.
Doria, G., M. Larguinho, J. T. Dias, E. Pereira, R. Franco, and P. V. Baptista. "Gold-silver-alloy nanoprobes for one-pot multiplex DNA detection." Nanotechnology 21 (2010): 255101. AbstractWebsite

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Doria, Gonçalo, Ricardo Franco, and Pedro Baptista. "Nanodiagnostics: Fast Colorimetric Method for Single Nucleotide Polymorphism/Mutation Detection." IET Nanobiotechnol. 1 (2007): 53-57.
Doria, G., J. Conde, B. Veigas, L. Giestas, C. Almeida, M. Assunção, J. Rosa, and P. V. Baptista. "Noble metal nanoparticles for biosensing applications." Sensors (Basel) 12 (2012): 1657-87. AbstractWebsite

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Doria, Gonçalo, Bernhard G. Baumgartner, Ricardo Franco, and Pedro V. Baptista. "Optimizing Au-nanoprobes for specific sequence discrimination." Colloids Surf. B: Biointerfaces 77 (2010): 122-124.
Doria, G., R. Franco, and P. Baptista. "Nanodiagnostics: fast colorimetric method for single nucleotide polymorphism/mutation detection." Iet Nanobiotechnology 1 (2007): 53-57. Abstract

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