@article {5318,
	title = {Synthesis of catecholamine conjugates with nitrogen-centered bionucleophiles},
	journal = {BIOORGANIC CHEMISTRY},
	volume = {{44}},
	year = {2012},
	note = {n/a},
	month = {Oct},
	pages = {{19-24}},
	publisher = {ACADEMIC PRESS INC ELSEVIER SCIENCE},
	address = {525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA},
	abstract = {<p>The enzymatic (tyrosinase) and chemical (NaIO4, Ag2O or Fremys\&apos;s salt) oxidation of biologically relevant catecholamines, such as dopamine (DA), N-acetyldopamine (NADA) and the Ecstasy metabolites (alpha-MeDA and N-Me-alpha-MeDA) generates the corresponding o-quinone which can be trapped with nitrogen bionucleophiles such as N-acetyl-histidine and imidazole in a regioselective reaction that takes place predominantly at the 6-position of the catecholamine. (C) 2012 Elsevier Inc. All rights reserved.</p>
},
	author = {Siopa, Filipa and Pereira, Alice S. and Ferreira, Luisa M. and Matilde Marques, M. and Branco, Paula S.}
}
