%0 Journal Article %J Catalysis Today %D 2020 %T Acidic porous carbons involved in the green and selective synthesis of benzodiazepines %A M. Godino-Ojer %A Matos, I. %A M. Bernardo %A Carvalho, R. %A Olívia Salomé {G.P. Soares} %A C. Durán-Valle %A I. M. Fonseca %A E. Pérez Mayoral %K activated carbons %K benzodiazepines %K Heterocyclic chemistry %K Heterogeneous catalytic systems %P 64 - 73 %R https://doi.org/10.1016/j.cattod.2019.11.027 %U http://www.sciencedirect.com/science/article/pii/S0920586118312938 %V 357 %X

Eco-sustainable and recyclable porous carbons are reported as metal-free catalysts for the synthesis of benzodiazepines for the first time. The porous carbons were able to efficiently catalyse the synthesis of benzodiazepine 1 from o-phenylendiamine 2 and acetone 3 under mild conditions. Both acidic functions and the porosity of the catalysts were determinant features. High conversion values were obtained when using HNO3 oxidized carbons. The highest selectivity to benzodiazepine 1 was obtained in the presence of the most microporous catalyst N-N, which is indicative of the great influence of porous properties. Stronger acid sites and high microporosity of the carbon treated with H2SO4 yield benzodiazepine 1 with total selectivity.

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SI: CarboCat–VIII