@article {C9CE00309F,
	title = {Crystal habit modification and polymorphic stability assessment of a long-acting β2-adrenergic agonist},
	journal = {CrystEngComm},
	volume = {21},
	year = {2019},
	note = {n/a},
	pages = {3460-3470},
	publisher = {The Royal Society of Chemistry},
	abstract = {<p>Properties such as particle orientation{,} flowability{,} packing{,} compaction{,} syringeability{,} suspension stability and dissolution are the most influenced by changes in the crystal habit and polymorphic form of a drug substance. The crystal habit of a drug substance (long-acting β2-adrenergic agonist (LABA)){,} as well as its purity and polymorphic stability{,} was studied after performing slurry tests with 1{,}2-dimethoxyethane : heptane solution at 50 {\textdegree}C. In these slurry tests{,} the product was kept suspended and undissolved{,} with agitation{,} for polymorphic conversion evaluation. Since no significant modifications were observed in the crystal shape and dimensions at 50 {\textdegree}C{,} a new slurry test was performed at a temperature above the melting point of the starting material (80 {\textdegree}C). In the latter test{,} it was possible to obtain crystals with increased dimensions by 480\% compared with the starting material. Additionally{,} the desired polymorphic form (form I) was obtained as well as an acceptable purity of approximately 99\%. These are promising results{,} not only for downstream purposes{,} but also concerning the bioavailability of the drug substance. This work shows that working at a temperature higher than the melting point of the compound seems to modify the crystal habit of the product.</p>
},
	doi = {10.1039/C9CE00309F},
	url = {http://dx.doi.org/10.1039/C9CE00309F},
	author = {Tulcidas, Ameessa and Louren{\c c}o, Nuno M. T. and Antunes, Rafael and Santos, Bruno and Sylwin Pawlowski and Rocha, Fernando}
}
