@article {adeoye2020cyclodextrin,
	title = {Cyclodextrin solubilization and complexation of antiretroviral drug lopinavir: In silico prediction; Effects of derivatization, molar ratio and preparation method},
	journal = {Carbohydrate Polymers},
	volume = {227},
	year = {2020},
	note = {<p>n/a</p>
},
	pages = {115287},
	publisher = {Elsevier},
	abstract = {<p>Lopinavir (LPV) is currently used in combination with ritonavir for the clinical management of HIV infections due to its limited oral bioavailability. Herein, we report the application of an in silico method to study cyclodextrin (CyD) host-guest molecular interaction with LPV for the rational selection of the best CyD for developing a CyD based LPV delivery system. The predicted CyD, a (2-hydroxy)propyl-gamma derivative with high degree of substitution (HP17-γ-CyD) was synthesized and comparatively evaluated with γ-CyD and the commercially available HP-γ-CyD. All complexes were prepared by supercritical assisted spray drying (SASD) and co-evaporation (CoEva) at molar ratios (1:1 and 1:2); and afterwards fully characterized. Results indicate a higher LPV amorphization and solubilization ability of HP17-γ-CyD. The SASD processing technology also enhanced LPV solubilization and release from complexes. The application of in silico methodologies is a feasible approach for the rational and/or deductive development of CyD drug delivery systems.</p>
},
	url = {https://www.sciencedirect.com/science/article/pii/S0144861719309543},
	author = {Adeoye, Oluwatomide and Concei{\c c}{\~a}o, Jaime and Serra, Patrr{\'\i}cia A and da Silva, Andreia Bento and Duarte, No{\'e}lia and Guedes, Rita C. and Corvo, Marta C. and Aguiar-Ricardo, Ana and Jicsinszky, L{\'a}szl{\'o} and Casimiro, Teresa and Cabral-Marques, Helena}
}
