Publications

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2010
Machado, CM, Couto F, Fernandes AR, Santos S, Cardim N, Freitas AT.  2010.  Unraveling Hypertrophic Cardiomyopathy Variability. ERCIM News J. 82:48-49.unraveling_hypertrophic_cardiomyopathy_variability.pdf
2011
Gromicho, M, Dinis J, Magalhaes M, Fernandes AR, Tavares P, Laires A, Rueff J, Rodrigues AS.  2011.  Development of imatinib and dasatinib resistance: dynamics of expression of drug transporters ABCB1, ABCC1, ABCG2, MVP, and SLC22A1. Leuk Lymphoma. 52(10):1980-90.11gromicholl.pdf
Santos, S, Lanca V, Oliveira H, Silveira L, Marques V, Brito D, Madeira H, Bicho M, Fernandes AR.  2011.  Genetic diagnosis of hypertrophic cardiomyopathy using mass spectrometry DNA arrays and high resolution melting. Rev Port Cardiol. 30(1):7-18.11santosrpc.pdf
Weis, SM, Cheresh DA.  2011.  Tumor angiogenesis: molecular pathways and therapeutic targets, 2011. 17 AbstractWebsite
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2012
Silva, TF, Martins LM, da Silva MFG, Fernandes AR, Silva A, Borralho PM, Santos S, Rodrigues CM, Pombeiro AJ.  2012.  Cobalt complexes bearing scorpionate ligands: synthesis, characterization, cytotoxicity and DNA cleavage. Dalton Trans. 41(41):12888-97.12silvadt.pdf
Santos, S, Marques V, Pires M, Silveira L, Oliveira H, Lanca V, Brito D, Madeira H, Esteves JF, Freitas A, Carreira IM, Gaspar IM, Monteiro C, Fernandes AR.  2012.  High resolution melting: improvements in the genetic diagnosis of hypertrophic cardiomyopathy in a Portuguese cohort. BMC Med Genet. 13:17.12santosbmcmg.pdf
Chohan, ZH, Shad HA, Supuran CT.  2012.  Synthesis, characterization and biological studies of sulfonamide Schiff’s bases and some of their metal derivatives, 2012. Journal of Enzyme Inhibition and Medicinal ChemistryJournal of Enzyme Inhibition and Medicinal Chemistry. 27(1):58-68.: Taylor & Francis AbstractWebsite
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2013
Silva, A, Luis D, Santos S, Silva J, Mendo AS, Coito L, Silva TF, da Silva MFG, Martins LM, Pombeiro AJ, Borralho PM, Rodrigues CM, Cabral MG, Videira PA, Monteiro C, Fernandes AR.  2013.  Biological characterization of the antiproliferative potential of Co(II) and Sn(IV) coordination compounds in human cancer cell lines: a comparative proteomic approach. Drug Metabol Drug Interact. 28(3):167-76.13silvadmdi.pdf
Silva, TF, Smolenski P, Martins LMDRS, da Silva MFG, Fernandes AR, Luis D, Silva A, Santos S, Borralho PM, Rodrigues CMP, Pombeiro AJL.  2013.  Cobalt and Zinc Compounds Bearing 1,10-Phenanthroline-5,6-dione or 1,3,5-Triaza-7-phosphaadamantane Derivatives - Synthesis, Characterization, Cytotoxicity, and Cell Selectivity Studies. Eur J Inorg Chem. 2013(21):3651-3658.13silvaejic.pdf
Gromicho, M, Magalhaes M, Torres F, Dinis J, Fernandes AR, Rendeiro P, Tavares P, Laires A, Rueff J, Rodrigues AS.  2013.  Instability of mRNA expression signatures of drug transporters in chronic myeloid leukemia patients resistant to imatinib. Oncol Rep. 29(2):741-50.13gromichoor.pdf
Fernandes, AR, Baptista PV.  2013.  Nanotechnology for Cancer Diagnostics and Therapy – An Update on Novel Molecular Players. Curr Canc Ther Rev. 9(3):164-172.nanotechnology_for_cancer_diagnostics_and_therapy_an_update.pdf
Martins, P, Rosa D, and Baptista AFPRV.  2013.  Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine, 2013. 3(2):105-118. Abstract

Traditional methods of drug delivery present several drawbacks, mainly due to off-target effects that mayoriginate severe side and toxic effect to healthy tissues. Parallel to the development of novel more effective drugs,
particular effort has been dedicated to develop and optimize drug delivery vehicles capable of specifically targeting the
required tissue/organ and to deliver the cargo only where and when it is needed. New drug delivery systems based on
nanoscale devices showing new and improved pharmacokinetic and pharmacodynamics properties like enhanced
bioavailability, high drug loading or systemic stability have surged in the past decade as promising solutions to the
required therapeutic efficacy. Amongst these nanoscale vectors, nanoparticles for drug delivery, such as polymeric, lipidbased,
ceramic or metallic nanoparticles, have been at the forefront of pharmaceutical development. The interest in
nanomedicine for treatment and diagnosis is clearly reflected on the increasing number of publications and issued patents
every year. Here, we provide a broad overview of novel nanoparticle based drug delivery systems, ranging from
polymeric systems to metal nanoparticles, while simultaneously listing the most relevant related patents.

2014
F. S. Silva, T, M. D. R. S. Martins L, Guedes da Silva FMC, Kuznetsov ML, Fernandes AR, Silva A, Pan C-J, Lee J-F, Hwang B-J, J. L. Pombeiro A.  2014.  Cobalt Complexes with Pyrazole Ligands as Catalyst Precursors for the Peroxidative Oxidation of Cyclohexane: X-ray Absorption Spectroscopy Studies and Biological Applications. Chemistry – An Asian Journal. 9:1132–1143., Number 4: WILEY-VCH Verlag AbstractWebsite
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Silva, J, Fernandes AR, Baptista PV.  2014.  Application of Nanotechnology in Drug Delivery. Application of Nanotechnology in Drug Delivery. (Ali Demir Sezer, Ed.)., Rijeka: InTech, Chapters published application_of_nanotechnology_in_drug_delivery.pdf
Veigas, B, Fernandes AR, Baptista PV.  2014.  AuNPs for identification of molecular signatures of resistance. Front Microbiol. 5:455.14veigasfm.pdf
Silva, J, Rodrigues AS, Videira PA, Lasri J, Charmier AJ, Pombeiro AJL, Fernandes AR.  2014.  Characterization of the antiproliferative potential and biological targets of a trans ketoimine platinum complex. Inorg Chim Acta. 423:156-167.
Silva, TF, Martins LM, Guedes da Silva MF, Kuznetsov ML, Fernandes AR, Silva A, Pan CJ, Lee JF, Hwang BJ, Pombeiro AJ.  2014.  Cobalt complexes with pyrazole ligands as catalyst precursors for the peroxidative oxidation of cyclohexane: X-ray absorption spectroscopy studies and biological applications. Chem Asian J. 9(4):1132-43.14silvacaj.pdf
Mahmudov, KT, da Silva MFCG, Kopylovich MN, Fernandes AR, Silva A, Mizar A, Pombeiro AJL.  2014.  Di- and tri-organotin(IV) complexes of arylhydrazones of methylene active compounds and their antiproliferative activity. J Organomet Chem. 760:67-73.14mahmudovjoc.pdf
Roma-Rodrigues, C, Fernandes AR, Baptista PV.  2014.  Exosome in tumour microenvironment: overview of the crosstalk between normal and cancer cells. Biomed Res Int. 2014:179486.14romarodriguesbmri.pdf
Roma-Rodrigues, C, Fernandes AR.  2014.  Genetics of hypertrophic cardiomyopathy: advances and pitfalls in molecular diagnosis and therapy. Appl Clin Genet. 7:195-208.14romarodriguesacg.pdf
Conde, J, Larguinho M, Cordeiro A, Raposo LR, Costa PM, Santos S, Diniz MS, Fernandes AR, Baptista PV.  2014.  Gold-nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis. Nanotoxicology. 8(5):521-32.14condenantox.pdf14condenantoxsuppl.pdf
Luis, DV, Silva J, Tomaz AI, de Almeida RF, Larguinho M, Baptista PV, Martins LM, Silva TF, Borralho PM, Rodrigues CM, Rodrigues AS, Pombeiro AJ, Fernandes AR.  2014.  Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies. J Biol Inorg Chem. 19(6):787-803.14luisjbic.pdf
Figueiredo, S, Cabral R, Luis D, Fernandes AR, Baptista PV.  2014.  Integration of Gold nanoparticles and liposomes for combined anti-cancer drug delivery. Nanomedicine. (Alexander Seifalian, Achala de Mel, Deepak M. Kalaskar, Eds.)., Manchester: One Central Press (OCP)conjugation_of_gold_nanoparticles_and_liposomes_for_combined_vehicles_of_drug_delivery_in_cancer.pdf
Martins, P, Marques M, Coito L, Pombeiro AJ, Baptista PV, Fernandes AR.  2014.  Organometallic compounds in cancer therapy: past lessons and future directions. Anticancer Agents Med Chem. 14(9):1199-212.14martinsaamc.pdf
Santos, S, Freitas AT, Fernandes AR.  2014.  Overview of HCM genomics and transcriptomics: molecular tools in HCM assessment for application in clinical medicine. Cardiovascular Disease II. , Hong Kong: iConcept Press Ltd.overview_of_hypertrophic_cardiomyopathy.pdf