@article {16162,
	title = {POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy},
	volume = {7},
	year = {2018},
	note = {n/a},
	month = {2018},
	pages = {772-779},
	abstract = {<p>Abstract POxylated polyurea dendrimer (PUREG4OOx48)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.</p>
},
	isbn = {2191-1363},
	url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/open.201800093},
	author = {Rita B. Restani and Rita F. Pires and Anna Tolmatcheva and Rita Cabral and Pedro V. Baptista and Alexandra R. Fernandes and Casimiro, Teresa and Vasco D.B. Bonif{\'a}cio and Aguiar-Ricardo, Ana}
}
