@article {16159,
	title = {Synthesis, Cytotoxicity Evaluation in Human Cell Lines and in Vitro DNA Interaction of a Hetero-Arylidene-9(10H)-Anthrone},
	volume = {2018},
	year = {2018},
	note = {n/a},
	month = {2018},
	pages = {545-549},
	abstract = {<p>A new and never before reported hetero-arylidene-9(10H)-anthrone structure (4) was unexpectedly isolated on reaction of 1,2-dimethyl-3-ethylimidazolium iodide (2) and 9-anthracenecarboxaldehyde (3) under basic conditions. Its structure was unequivocally confirmed by X-ray crystallography. No cytotoxicity in human healthy fibroblasts and in two different cancer cell lines was observed, indicating its applicability in biological systems. Compound 4 interacts with CT-DNA by intercalation between the adjacent base pairs of DNA with a high binding affinity [Kb = 2.0 ({\textpm}0.20) {\texttimes} 105 m{\textendash}1], which is 10 {\texttimes} higher than that described for doxorubicin [Kb = 3.2 ({\textpm}0.23) {\texttimes} 104 m{\textendash}1]. Furthermore, compound 4 quenches the fluorescence emission of a GelRed{\textendash}CT-DNA system with a quenching constant (KSV) of 3.3 ({\textpm}0.3) {\texttimes} 103 m{\textendash}1 calculated by the Stern{\textendash}Volmer equation.</p>
},
	isbn = {1434-193X},
	url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201701500},
	author = {Peixoto, Daniela and Figueiredo, Margarida and Malta, Gabriela and Catarina Roma-Rodrigues and Pedro V. Baptista and Alexandra R. Fernandes and Barroso, S{\'o}nia and Ana Lu{\'\i}sa Carvalho and Afonso, Carlos A. M. and Ferreira, Luisa M. and Branco, Paula S.}
}
